What about novel pathogenetic mechanisms in Multiple Sclerosis? The emerging role of mitochondria
Dear Editor (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 12, 2018 Category: Biomedical Science Authors: Simona Portaro, Antonino Naro, Vincenzo Cimino, Rocco Salvatore Calabr ò Source Type: research
Treatment of Anorexia Nervosa with Palmitoylethanoamide
This hypothesis is grounded on evidence that the endocannabinoid system (ECS) is intimately involved in the pathogenesis of anorexia nervosa (AN). The premise for suggesting that palmitoylethanoamide (PEA), which is a commercially available nutraceutical could ameliorate these disorders, is based the parable of the drunkard who is searching tirelessly under a streetlamp in the nighttime. A policeman approaches, and asks what he has lost. “My keys” he answers, and so the policeman helps him search. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 12, 2018 Category: Biomedical Science Authors: Barbara Scolnick Source Type: research
Why is vitamin B6 effective in alleviating the symptoms of autism?
Many factors are reported to be involved in the complex pathophysiological processes of autism, suggesting that there is considerable variability in the manifestations of this disease. Several interventions are used to treat this disorder. Among them, vitamin B6 is widely used to treat the symptoms observed in autism. Vitamin B6 is beneficial for about half of autistic individuals in decreasing behavioral problems. However, until now, it remains unknown why vitamin B6 is effective for this disease. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 12, 2018 Category: Biomedical Science Authors: Kohji Sato Source Type: research
Chaos theory for clinical manifestations in multiple sclerosis
Multiple sclerosis (MS) is a demyelinating disease which characteristically shows repeated relapses and remissions irregularly in the central nervous system. At present, the pathological mechanism of MS is unknown and we do not have any theories or mathematical models to explain its disseminated patterns in time and space. In this paper, we present a new theoretical model from a viewpoint of complex system with chaos model to reproduce and explain the non-linear clinical and pathological manifestations in MS. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 11, 2018 Category: Biomedical Science Authors: Tetsuya Akaishi, Toshiyuki Takahashi, Ichiro Nakashima Source Type: research
Psychiatric benefits of lithium in water supplies may be due to protection from the neurotoxicity of lead exposure
Lithium is a medication used to treat bipolar disorder and may also prevent cognitive decline and suicide. Lithium is also found naturally, in levels well below clinical doses, in drinking water worldwide, and levels have been inversely associated with rates of psychiatric disorders. Lead (Pb) is another element in the environment but is a toxin of public health concern. Negative effects of chronic lead exposure and possible benefits of environmental lithium exposure appear complementary. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 11, 2018 Category: Biomedical Science Authors: Eric E. Brown, Philip Gerretsen, Bruce Pollock, Ariel Graff-Guerrero Source Type: research
Chaos theory for Clinical Manifestations in Multiple Sclerosis
Multiple sclerosis (MS) is a demyelinating disease which characteristically shows repeated relapses and remissions irregularly in the central nervous system. At present, the pathological mechanism of MS is unknown and we do not have any theories or mathematical models to explain its disseminated patterns in time and space. In this paper, we present a new theoretical model from a viewpoint of complex system with chaos model to reproduce and explain the non-linear clinical and pathological manifestations in MS. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 11, 2018 Category: Biomedical Science Authors: Tetsuya Akaishi, Toshiyuki Takahashi, Ichiro Nakashima Source Type: research
Psychiatric benefits of lithium in water supplies may be due to protection from the neurotoxicity of lead exposure.
Lithium is a medication used to treat bipolar disorder and may also prevent cognitive decline and suicide. Lithium is also found naturally, in levels well below clinical doses, in drinking water worldwide, and higher levels have been associated with lower rates of psychiatric disorders. Lead is another element in the environment but is a toxin of public health concern. Negative effects of chronic lead exposure and possible benefits of environmental lithium exposure appear complementary.Hypothesis:Exposure to environmental lithium has associated benefits, which may be due to the mitigation of lead toxicity by lithium. (Sour...
Source: Medical Hypotheses - April 11, 2018 Category: Biomedical Science Authors: Eric E. Brown, Philip Gerretsen, Bruce Pollock, Ariel Graff-Guerrero Source Type: research
May inflammatory markers be used for monitoring the continuous positive airway pressure effect in patients with obstructive sleep apnea and arrhythmias?
Obstructive sleep apnea syndrome (OSAS) is defined by recurrent episodes of significant reduction or absence of the oro-nasal airflow during sleep, in the presence of thorax and abdominal movements and snoring. The pathophysiological consequences of intermittent hypoxia determined by OSAS are represented by systemic inflammation, the release of free oxygen radicals and activation of the sympathetic nervous system. Cardiac arrhythmias are a frequent comorbidity in patients with OSAS. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 10, 2018 Category: Biomedical Science Authors: G.N. Dediu, C.C. Diaconu, S. Dumitrache Rujinski, M.A. Iancu, L.A. Balaceanu, I. Dina, M. Bogdan Source Type: research
Evaluation of isoprinosine to be repurposed as an adjunct anti-tuberculosis chemotherapy
Isoprinosine (Inos) or immunovir is a synthetic purine derivative with immune-modulatory and antiviral properties. The drug shows apparent in vivo enhancement of host immune responses by inducing pro-inflammatory cytokines and rapid proliferation of T-cell subsets. Strikingly, the cytokines induced by Inos also play crucial roles in providing immune resistance against Mycobacterium tuberculosis (Mtb). Inos has been licensed for several antiviral diseases; however, its efficacy against Mtb has not been tested yet. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 10, 2018 Category: Biomedical Science Authors: Alok K. Mishra, Shivraj M. Yabaji, Rikesh K. Dubey Source Type: research
May inflammatory markers be used for monitoring the continuous positive airway pressure effect in patients with obstructive sleep apnea and arrhythmias?
Obstructive sleep apnea syndrome (OSAS) is defined by recurrent episodes of significant reduction or absence of the oro-nasal airflow during sleep, in the presence of thorax and abdominal movements and snoring. The pathophysiological consequences of intermittent hypoxia determined by OSAS are represented by systemic inflammation, the release of free oxygen radicals and activation of the sympathetic nervous system. Cardiac arrhythmias are a frequent comorbidity in patients with OSAS. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 10, 2018 Category: Biomedical Science Authors: GN Dediu, CC Diaconu, S. Dumitrache Rujinski, A Iancu, A Balaceanu, I Dina, M Bogdan Source Type: research
Evaluation of Isoprinosine to be Repurposed as an Adjunct Anti-tuberculosis Chemotherapy
Isoprinosine (Inos) or immunovir is a synthetic purine derivative with immune-modulatory and antiviral properties. The drug shows apparent in vivo enhancement of host immune responses by inducing pro-inflammatory cytokines and rapid proliferation of T-cell subsets. Strikingly, the cytokines induced by Inos also play crucial roles in providing immune resistance against mycobacterium tuberculosis (Mtb). Inos has been licensed for several antiviral diseases; however, its efficacy against Mtb has not been tested yet. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 10, 2018 Category: Biomedical Science Authors: Alok K. Mishra, Shivraj M. Yabaji, Rikesh K. Dubey Source Type: research
Correlation between immunological-inflammatory markers and endothelial disfunction in the early stage of coronary heart disease
Classical risk factors for endothelial dysfunction (ED), such as age, gender, total cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, and smoking history are utilised for the Framingham score and Systemic Coronary Risk Estimation (SCORE) for evaluation of the 10-year cardiovascular risk in routine practice. Nonetheless, pro-inflammatory mediators are deeply involved in the initiation and the progression of ED and coronary artery disease (CAD), and act additionally or independently of metabolic factors before clinical manifestations of the disease appear. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 9, 2018 Category: Biomedical Science Authors: Viktor Persic, Ana Lanca Bastiancic, Ivan Rosovic, Damir Raljevic, Dijana Travica Samsa, Luka Bastiancic, Rajko Miskulin, Marko Boban, Gordana Laskarin Source Type: research
Correlation Between Immunological-Inflammatory Markers and Edothelial Disfunction in The Early Stage of Coronary Heart Disease
Classical risk factors for endothelial dysfunction (ED), such as age, gender, total cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, and smoking history are utilised for the Framingham score and Systemic Coronary Risk Estimation (SCORE) for evaluation of the 10-year cardiovascular risk in routine practice. Nonetheless, pro-inflammatory mediators are deeply involved in the initiation and the progression of ED and coronary artery disease (CAD), and act additionally or independently of metabolic factors before clinical manifestations of the disease appear. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 9, 2018 Category: Biomedical Science Authors: Viktor Persic, Ana Lanca Bastiancic, Ivan Rosovic, Damir Raljevic, Dijana Travica Samsa, Luka Bastiancic, Rajko Miskulin, Marko Boban, Gordana Laskarin Source Type: research
Medical information security in the era of artificial intelligence
In recent years, biometric technologies, such as iris, facial, and finger vein recognition, have reached consumers and are being increasingly applied. However, it remains unknown whether these highly specific biometric technologies are as safe as declared by their manufacturers. As three-dimensional (3D) reconstruction based on medical imaging and 3D printing are being developed, these biometric technologies may face severe challenges. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 5, 2018 Category: Biomedical Science Authors: Yufeng Wang, Liwei Wang, Chang-ao Xue Source Type: research
