Premature ageing mutations at the nuclear periphery
Publication date: July 2017 Source:Mechanisms of Development, Volume 145, Supplement Author(s): Colin L. Stewart, Alex Chojnowski, Rafidah Mutalif, Esther Wong, Oliver Dreesen (Source: Mechanisms of Development)
Source: Mechanisms of Development - June 13, 2017 Category: Biology Source Type: research
Strategies to enhance the regenerative functions of aging stem cells
Publication date: July 2017 Source:Mechanisms of Development, Volume 145, Supplement Author(s): Amy J. Wagers (Source: Mechanisms of Development)
Source: Mechanisms of Development - June 13, 2017 Category: Biology Source Type: research
How fish colour their skin: A paradigm for development and evolution of adult patterns
Publication date: July 2017 Source:Mechanisms of Development, Volume 145, Supplement Author(s): Christiane Nüsslein-Volhard (Source: Mechanisms of Development)
Source: Mechanisms of Development - June 13, 2017 Category: Biology Source Type: research
Cell and tissue mechanics in zebrafish gastrulation
Publication date: July 2017 Source:Mechanisms of Development, Volume 145, Supplement Author(s): Carl-Philipp Heisenberg (Source: Mechanisms of Development)
Source: Mechanisms of Development - June 13, 2017 Category: Biology Source Type: research
MechanoDevo: How growth and form derived mechanical forces channel plant morphogenesis
Publication date: July 2017 Source:Mechanisms of Development, Volume 145, Supplement Author(s): Olivier Hamant (Source: Mechanisms of Development)
Source: Mechanisms of Development - June 13, 2017 Category: Biology Source Type: research
On the Growth and Form of the Zebrafish Myotome
Publication date: July 2017 Source:Mechanisms of Development, Volume 145, Supplement Author(s): J.-F. Rupprecht, S. Tlili, J. Yin, J. Prost, T.E. Saunders (Source: Mechanisms of Development)
Source: Mechanisms of Development - June 13, 2017 Category: Biology Source Type: research
Left-right symmetry breaking in the mouse embryo
Publication date: July 2017 Source:Mechanisms of Development, Volume 145, Supplement Author(s): Hiroshi Hamada (Source: Mechanisms of Development)
Source: Mechanisms of Development - June 13, 2017 Category: Biology Source Type: research
Visualization of transcriptional regulation via long-distance enhancer-promoter interactions
Publication date: July 2017 Source:Mechanisms of Development, Volume 145, Supplement Author(s): Hongtao Chen, Lev Barinov, Thomas Gregor (Source: Mechanisms of Development)
Source: Mechanisms of Development - June 13, 2017 Category: Biology Source Type: research
On The Growth and Form of the Vertebrate Neural Tube
Publication date: July 2017 Source:Mechanisms of Development, Volume 145, Supplement Author(s): James Briscoe (Source: Mechanisms of Development)
Source: Mechanisms of Development - June 13, 2017 Category: Biology Source Type: research
SOX7 expression is critically required in FLK1-expressing cells for vasculogenesis and angiogenesis during mouse embryonic development
Publication date: August 2017 Source:Mechanisms of Development, Volume 146 Author(s): Andrew J. Lilly, Andrzej Mazan, Daryl A. Scott, Georges Lacaud, Valerie Kouskoff The transcriptional program that regulates the differentiation of endothelial precursor cells into a highly organized vascular network is still poorly understood. Here we explore the role of SOX7 during this process, performing a detailed analysis of the vascular defects resulting from either a complete deficiency in Sox7 expression or from the conditional deletion of Sox7 in FLK1-expressing cells. We analysed the consequence of Sox7 deficiency from E7...
Source: Mechanisms of Development - June 13, 2017 Category: Biology Source Type: research
Knockdown of epigenetic transcriptional co-regulator Brd2a disrupts apoptosis and proper formation of hindbrain and midbrain-hindbrain boundary (MHB) region in zebrafish
Publication date: August 2017 Source:Mechanisms of Development, Volume 146 Author(s): Tami Murphy, Heather Melville, Eliza Fradkin, Giana Bistany, Gregory Branigan, Kelly Olsen, Catharine R. Comstock, Hayley Hanby, Ellie Garbade, Angela J. DiBenedetto Brd2 is a member of the bromodomain-extraterminal domain (BET) family of proteins and functions as an acetyl-histone-directed transcriptional co-regulator and recruitment scaffold in chromatin modification complexes affecting signal-dependent transcription. While Brd2 acts as a protooncogene in mammalian blood, developmental studies link it to regulation of neuron...
Source: Mechanisms of Development - June 13, 2017 Category: Biology Source Type: research
An analysis of MyoD-dependent transcription using CRISPR/Cas9 gene targeting in Xenopus tropicalis embryos
Publication date: August 2017 Source:Mechanisms of Development, Volume 146 Author(s): Caitlin McQueen, Mary Elizabeth Pownall Myogenic regulatory factors (MRFs) are known to have essential roles in both the establishment and differentiation of the skeletal muscle cell lineage. MyoD is expressed early in the Xenopus mesoderm where it is present and active several hours before the activation of muscle differentiation genes. Previous studies in cultured cells and in Xenopus laevis have identified sets of genes that require MyoD prior to differentiation of skeletal muscle. Here we report results from experiments using CRIS...
Source: Mechanisms of Development - June 13, 2017 Category: Biology Source Type: research
Discovery of a novel oocyte-specific Kr üppel-associated box domain-containing zinc finger protein required for early embryogenesis in cattle
Publication date: Available online 2 March 2017 Source:Mechanisms of Development Author(s): Jacqelyn M. Hand, Kun Zhang, Lei Wang, Prasanthi P. Koganti, Kristen Mastrantoni, Sandeep K. Rajput, Mohamed Ashry, George W. Smith, Jianbo Yao Zinc finger (ZNF) transcription factors interact with DNA through zinc finger motifs and play important roles in a variety of cellular functions including cell growth, proliferation, development, apoptosis, and intracellular signal transduction. One-third of ZNF proteins in metazoans contain a highly conserved N-terminal motif known as the Krüppel-associated box (KRAB) domain, wh...
Source: Mechanisms of Development - March 2, 2017 Category: Biology Source Type: research
How complexity increases in development: An analysis of the spatial-temporal dynamics of Gene expression in Ciona intestinalis
Publication date: Available online 9 February 2017 Source:Mechanisms of Development Author(s): Irepan Salvador-Martínez, Isaac Salazar-Ciudad The increase in complexity in an embryo over developmental time is perhaps one of the most intuitive processes of animal development. It is also intuitive that the embryo becomes progressively compartmentalized over time and space. In spite of this intuitiveness, there are no systematic attempts to quantify how this occurs. Here, we present a quantitative analysis of the compartmentalization and spatial complexity of Ciona intestinalis over developmental time by analyzing thousa...
Source: Mechanisms of Development - February 9, 2017 Category: Biology Source Type: research
Chemical activation of Wnt/ β-catenin signalling inhibits innervation and causes skeletal tissue malformations during axolotl limb regeneration
In conclusion, we found that limb regeneration was differentially affected depending on the stage at which the Wnt signalling pathway was activated. (Source: Mechanisms of Development)
Source: Mechanisms of Development - February 3, 2017 Category: Biology Source Type: research
