Validation of steroid sulfates deconjugation for metabolic studies. Application to human urine samples
Publication date: Available online 17 October 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): D. Martinez-Brito, M.L. Notarianni, M. Iannone, X. de la Torre, F. Botrè (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 18, 2020 Category: Drugs & Pharmacology Source Type: research

Development of a method to determine cytochrome P450 1A2, 2C9, 2D6 and 3A4 activity sheep hepatic microsomes
Publication date: Available online 18 October 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Grace M. McBride, Jia Yin Soo, Tamara Varcoe, Janna L. Morrison, Michael D. Wiese (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 18, 2020 Category: Drugs & Pharmacology Source Type: research

Reprint of: Nonclinical species sensitivity to convulsions: An IQ DruSafe consortium working group initiative
Publication date: Available online 30 September 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Jamie K. DaSilva, Laura Breidenbach, Tracy Deats, Dingzhou Li, Kimberly Treinen, Theo Dinklo, Sophie Kervyn, Greet Teuns, Martin Traebert, Katja Hempel (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 2, 2020 Category: Drugs & Pharmacology Source Type: research

Novel microvascular endothelial model utilizing a collagen vitrigel membrane and its advantages for predicting histamine-induced microvascular hyperpermeability
Publication date: Available online 3 September 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Miaki Uzu, Toshiaki Takezawa (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - September 3, 2020 Category: Drugs & Pharmacology Source Type: research

Characterization of iCell cardiomyocytes using single-cell RNA-sequencing methods
Publication date: Available online 29 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Christina Schmid, Christian T. Wohnhaas, Tobias Hildebrandt, Patrick Baum, Georg Rast (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 30, 2020 Category: Drugs & Pharmacology Source Type: research

Is there a role for the no observed adverse effect level in safety pharmacology?
Publication date: Available online 29 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Tomas Mow, Ninette K. Andersen, Nils Dragsted, Anders B. Lassen, Morten Laursen, Alan S. Bass, Jean-Pierre Valentin, Carrie Markgraf, Simon Authier, Ted J. Baird, Siddhartha Bhatt, Martin Traebert, Derek J. Leishman, David Jones, Michael J. Curtis (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 30, 2020 Category: Drugs & Pharmacology Source Type: research

In vitro model using cytokine cocktail to evaluate apoptosis in Min6 pancreatic beta cells
Publication date: Available online 20 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Hemangee H. Damame, Sheetalnath B. Rooge, Rahul S. Patil, Akalpita U. Arvindekar (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 21, 2020 Category: Drugs & Pharmacology Source Type: research

Establishment of drug screening in human embryonic stem cells based on a high-content screening system
Publication date: Available online 19 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Yunfen Hua, Yongqin Wu, Xing Chun, Huarong Huang, Junyan Yan, Baowei Hu, Ming Zhang, Lifang Jin (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 20, 2020 Category: Drugs & Pharmacology Source Type: research

Revisiting the hERG safety margin after 20 years of routine hERG screening
Publication date: Available online 5 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Derek J. Leishman, Matthew M. Abernathy, Evan B. Wang (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 15, 2020 Category: Drugs & Pharmacology Source Type: research

Schiefer counter: An alternative method for clonogenic assay evaluation
Publication date: Available online 14 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): A.F. Santos, E.M. Schiefer, M.C. Atherino, J.C. Atherino, L.H. Negri, A.M. Weffort-Santos, A.R. Crisma, W.M. de Souza, K.B. Felipe (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 14, 2020 Category: Drugs & Pharmacology Source Type: research

Twenty years of safety pharmacology model validation and the wider implications of this to drug discovery
Publication date: Available online 14 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Michael K. Pugsley, Bisrat Bekele, Helene Griessel, Tessa de Korte, Simon Authier, Anne F. Grobler, Carrie G. Markgraf, Michael J. Curtis (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 14, 2020 Category: Drugs & Pharmacology Source Type: research

Revisiting the hERG safety margin after 20 years of routine hERG screening
Publication date: Available online 5 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Derek J. Leishman, Matthew M. Abernathy, Evan B. Wang (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 12, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation of urinary biomarkers for early detection of acute kidney injury in a rat nephropathy model
Publication date: Available online 7 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Kristina Kohl, Eva Herzog, Gerhard Dickneite, Sabine Pestel (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 12, 2020 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: July–August 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 104Author(s): (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 4, 2020 Category: Drugs & Pharmacology Source Type: research

A Bayesian approach to toxicological testing
Publication date: Available online 29 July 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): James C. Felli, Derek J. Leishman (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 30, 2020 Category: Drugs & Pharmacology Source Type: research