Journal of Pharmacological and Toxicological Methods This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A translational research approach for cardiovascular safety assessment at Janssen
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Ard Teisman, Ammel, Vijay Urmaliya, David J. Gallacher (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

A translational analysis: In vitro hiPSC cardiomyocytes to human phase I analysis for a set of reference compounds with different QT/TdP risk categories
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Karel Van Ammel, Vijay Urmaliya, Hua Rong Lu, Jutta Rohrbacher, Ivan Kopljar, Hanne Jansen, David J. Gallacher, Ard Teisman (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

A translational analysis: Cardiac ion channels and isolated rabbit left ventricular wedge in predicting CV safety risk
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Jutta Rohrbacher, Hanne Jansen, Karel Van Ammel, Hua Rong Lu, Vijay Urmaliya, Ard Teisman, David J. Gallacher (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Translational research: What can we learn from the predictability of anesthetized guinea-pig and dog models for cardiovascular safety findings in man?
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Hanne Jansen, Vijay Urmaliya, Karel Van Ammel, Henk van der Linde, Jutta Rohrbacher, Ard Teisman, David J. Gallacher (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

An integrated translational analysis summary: Prediction of HERG, isolated wedge preparation, anaesthetized guinea pig and dog towards phase I clinical data for drugs with different QT/TdP risk categories
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Vijay Urmaliya, Karel Van Ammel, Jutta Rohrbacher, Henk van der Linde, Hua Rong Lu, Hanne Jansen, David J. Gallacher, Ard Teisman (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of cardiac function after cardioplegic treatment in isolated rabbit hearts
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Ziva Arimura, BaoXi Gao, Mei Fang, Yusheng Qu, Hugo Vargas (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

New approach for neuropharmacology profile: In-situ real-time neuropharmacology monitoring by imaging technique using the molecularly imprinted polymers (MIPs) probe
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Takashi Inutsuka, Maya Okamoto, Yasuo Yoshimi (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

H3B-6545, a selective estrogen receptor covalent antagonist, prevents bone loss in ovariectomized Sprague-Dawley rats
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Amy H. Kim, Manav Korpal, Renee Hukkanen, Nathalie Rioux, Markus Warmuth, Peter Smith (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

The effect of DMSO on the contraction and relaxation of isolated thoracic aorta of the CRL:WI(Han) rat
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Jason D. Payseur, Xuejun Wu, Sandra L. Turner, Konuralp Bayrak, Anthony Bahinski, Eric I. Rossman (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Can cardiovascular liabilities be detected earlier in drug development? Assessing the translation of tyrosine kinase inhibitors from cardiomyocytes and isolated hearts to whole animal
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Jennifer Shaffer, John Ross, Carlos A. Obejero-Paz, Michelle Waines, Andrew Bruening-Wright, Brian Roche (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Assessment of multiple positive controls in the Langendorff isolated heart assay and how they translate to whole animal
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Tyler Ardrey, John Ross, Michelle Waines, Tyree Campbell, Pritesh Patel, Brian Roche (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Proof of concept comprehensive ex vivo neurological assay
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Lois Miraucourt, Michael Accardi, Hai Huang, Simon Authier (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Occurrence of spontaneous arrhythmias in freely moving non-treated healthy telemetered Sprague-Dawley rats
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Paula Juliana Brizuela de Seadi Pereira, Mylene Pouliot, Alison Easter, Claudia Harper, Annick Prefontaine, Lois Miraucourt, Wendy Tan, Mohamed Said Maghezzi, Rob Wallis, Simon Authier (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Dual effect of clonidine on QT interval duration and body temperature in cynomolgus monkeys: QT correction formula for changes in core body temperature
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Abdel-Ilah El Amrani, Hai Huang, Stephane Loriot, Francine El Amrani, Pramila Singh, Simon Authier, Roy Forster (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Validation of gluteus medius muscle electromyographic (EMG) recording by telemetry in socialized cynomolgus monkeys
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Christophe Bory, David Coquard, Olivier Boucheix, Stephane Baudet (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research