Journal of Pharmacological and Toxicological Methods This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

CSAHi study: Detection of drug-induced seizure-like activities of three convulsants at five facilities using micro-electrode arrays in combination with human iPS cell-derived neurons
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Yuto Ishibashi, Aoi Odawara, Takafumi Shirakawa, Kenichi Kinoshita, Ai Okamura, Norimasa Miyamoto, Atsuko Ojima, Takuya Kondo, Rie Hando, Kaoru Morimura, Kaoru Sato, Ikuro Suzuki (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Detection of drug-induced seizure-like activities using MEA system in cultured human iPSC-derived neurons: Report from multi-site pilot study of the HESI NeuTox committee in collaboration with CSAHi and iNCENS
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Aoi Odawara, Yuto Ishibashi, Naoki Matsuda, Ikuro Suzuki (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Deep learning on MEA data obtained from human iPS cell-derived neurons for predicting seizure risk of new drugs
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Naoki Matsuda, Aoi Odawara, Ai Okamura, Kenichi Kinoshita, Takafumi Shirakawa, Ikuro Suzuki (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Physiologically-relevant anisotropic 384-well high-throughput hiPSC-derived cardiomyocyte cultures provide better resolution over safety profiles of compounds with known cardiotoxic mechanisms of action
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Riccardo Contu, Robert Padilla, Stephan Spangenberg, Alisom Fanton, Brittney Van Hese, Alec Witty, Fabian Zanella (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

High-throughput and high-content safety pharmacology assessments with 3-dimensional human induced pluripotent stem cell-derived cortical spheroid platforms
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Steven Dea, Steven Biesmans, Sergio Mora-Castilla, Sarah Romero, Neha Sodhi, Aurian Saleh, Grace Woodruff, Tony Harrington, Fabian Zanella, Cassiano Carromeu (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Functional evaluation of neurotoxic compounds using human iPSC–derived neuronal 3D cultures
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Oksana Sirenko, Sarah Vargas-Hurlston, Grischa Chandy, Carole Crittenden, Ryan Gordon, Oivin Guicherit, Fabian Zanella, Cassiano Carromeu (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Hight-throughput profiling of seizuregenic liability using human iPSC–derived neuronal 3D cultures
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Carsten Andersen, Steven Dea, Ryan Gordon, Oivin Guicherit, Fabian Zanella, Cassiano Carromeu (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacological evaluation of disease relevant iPSC-derived cardiomyocyte models
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Xiaoyu Zhang, Yama A. Abassi (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Cardiotoxicity evaluation using three-dimensional cardiac tissues consisting of human iPS cell-derived cardiomyocytes and fibroblasts by cell coating technique
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Kiyoshi Tadano, Katsuyuki Kazusa, Kazuhiko Takamatsu, Hitoshi Naraoka, Maki Takeda, Mitsuru Akashi, Shigeru Miyagawa, Yoshiki Sawa (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Silver nanoparticles inhibits neural differentiation in human iPS Cells
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Shigeru Yamada, Daiju Yamazaki, Yasunari Kanda (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

In vivo monitoring of gastrointestinal transit: The SmartPill®
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Helga Lorenz, Gerhard Marsch, Paul Germann (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Current nonclinical in vivo safety pharmacology testing enables safe entry to first-in-human clinical trials: The IQ consortium nonclinical to clinical translational database
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): David Ackley, Matthew Abernathy, Alysia Chaves, Bruce Damiano, Annie Delaunois, Michael Foley, Andrea Greiter-Wilke, Jean-Michel Guillon, Jonathan Maher, Tom Monticello, Malar Pannirselvam, Jon Renninger, Hugo Vargas (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Comparison of three analytical methods for superoxide produced by activated immune cells
Publication date: Available online 31 October 2019Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Zhixiang Zhu, Ran Guo, Yunqian Li, Shanshan Li, Pengfei TuAbstractSuperoxide plays a key role in normal immune function and inflammatory diseases. In order to evaluate normal immune function or screen inhibitors of superoxide production for treating inflammatory diseases, it is very important to detect superoxide with good accuracy, sensitivity, and flexibility. In present study, we investigated three analysis methods of superoxide, colorimetric assay by WST-8, fluorescence assay by dihydroethidium and c...
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Precipitation of test chemicals in reaction solutions used in the amino acid derivative reactivity assay and the direct peptide reactivity assay
Publication date: Available online 22 August 2019Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Yusuke Yamamoto, Sayaka Wanibuchi, Ayako Sato, Toshihiko Kasahara, Masaharu FujitaAbstractThe Amino acid Derivative Reactivity Assay (ADRA) was developed by the authors as an in chemico alternative to animal testing for skin sensitization potential. Although ADRA is based on the same scientific principles as the Direct Peptide Reactivity Assay (DPRA), a comparison of the results from these two test methods shows a far lower incidence of precipitation of test chemicals in reaction solutions for ADRA than f...
Source: Journal of Pharmacological and Toxicological Methods - August 24, 2019 Category: Drugs & Pharmacology Source Type: research

A label-free approach to detect cell viability/cytotoxicity based on intracellular xanthine/guanine by electrochemical method
In this study, an electrochemical method for detecting cell viability and cytotoxicity was discussed with the intracellular small molecule metabolite purines as indexes.MethodsThe electrochemical behaviors of Balb/c 3T3, CHO, PC-12 and V79 cell suspensions were studies by cyclic voltammetry, and cell viability and cytotoxicity of four cell lines were compared by electrochemical, cell counting, 3-(4,5-dimethyl-2-Thiazyl)-2, 5-diphenyl-2H-tetrazolium bromide (MTT) and trypan blue exclusion methods.ResultsFour cell lines all showed an oxidation peak derived from mixture of xanthine and guanine at about 0.7 V. Using intracel...
Source: Journal of Pharmacological and Toxicological Methods - August 22, 2019 Category: Drugs & Pharmacology Source Type: research