Journal of Pharmacological and Toxicological Methods This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

An in silico predictive model for TdP based on multiple ion channel inhibition
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Todd Wisialowski, Stephen Jenkinson, Mark Gosink (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Challenge for the in silico translation of Na channel blockade effects on human-ECG parameters
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Takashi Yoshinaga, Taeko Kubo, Keiichi Asakura, Yasuyuki Abe, Ryuuta Saitou, Takafumi Shirakawa, Yoshiyuki Furukawa, Takashi Ashihara (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Comparison of telemetry-derived activity generated from rodent cardiovascular studies with quantitative open field locomotor activity
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Vincent Bernardo, Cheryl Tyszkiewicz, Siddhartha Bhatt, Todd Wisialowski, Susan Goody (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Use of PK/PD modelling of nonclinical cardiovascular data to aid in ex vivo-to-in vivo and cross-species translation
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): William Gorczyca, Todd Wisialowski, Jennifer Colangelo (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Prediction of drug-effects on cardiac repolarization in humans: What can we learn from the past to refine our drug discovery strategies?
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Jean-Pierre Valentin, Jean-Michel Guillon, Peter K. Hoffman, Catherine Ortemann-Renon, John Koerner, Jennifer Pierson, Gary A. Gintant, James Willard, Matthew Skinner, Todd Wisialowski, Michael Pugsley (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Hypothermia-induced QTc prolongation in non-human primates; Why you should measure body temperature in cardiovascular safety studies
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Todd Wisialowski, Jason Cordes, Betty Pettersen, Declan Flynn (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of cardiovascular risk related to a monoclonal antibody mediated increase in vascular endothelial growth factor in conscious normal rats
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Kathy Derakhchan, Ruth Reeves, Dennis Keefe, Suezanne Parker, Galen Carey (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Concordance of Ion Channel, Cardiomyocyte, and Preclinical Species in Proarrhythmia Cardiac Safety Evaluation
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Emily P. Kaushik (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Moving from detection of cardiovascular liabilities to quantitative mechanistic understanding: Concepts, challenges and opportunities
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Amy Pointon, Michael G. Rolf (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Integrating efficacy and safety: Telemetry and echocardiography in a pig model of myocardial infarction
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Michael G. Rolf, Stuart Purbrick, Madeleine Antonsson, Frank Seeliger, Martin Billger (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Development and characterization of a nerve conduction model in anesthetized non-human primates as a tool to assess compound-dependent peripheral nervous system risk
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Theodore Detwiler, Christopher Regan, Hillary Regan, Gary Sitko, Frederick Sannajust (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Getting more from blood pressure signals: Use of pulse wave analysis (PWA) to enable greater insight to compound-dependent hemodynamic effects
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Christopher Regan, Hillary Regan, Patrick Fanelli, Frederick Sannajust (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Measurement of heart rate variability (HRV) and spontaneous baroreflex sensitivity (sBRS) provides valuable information on compound-dependent cardiovascular effects to enhance safety risk assessment
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Christopher Regan, Patrick Fanelli, Hillary Regan, Theodore Detwiler, Pierre Morissette, Shaun Gruver, Frederick Sannajust (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of clinically-relevant proarrhythmic ECG biomarkers in conscious beagle dogs using a newly developed multiple lead ECG telemetry implant
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Christopher Regan, Tom Delahanty, Robert Brockway, Patrick Fanelli, Hillary Regan, Theodore Detwiler, Shaun Gruver, Gary Miller, Frederick Sannajust (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Is the current non-clinical drug development safety paradigm effective for assessing cardiovascular liabilities?
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Brian Roche, John Ross, Carlos A. Obejero-Paz, James Kramer (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research