Journal of Oncology Pharmacy Practice This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Hyperammonemia secondary to asparaginase: A case series
Conclusion Hyperammonemia can occur during treatment of acute lymphoblastic leukemia with asparaginase products. Lactulose appears to be a useful treatment strategy. Further study is warranted to determine whether dose modifications are required for pegaspargase in some patients. Whether these dose modifications would be in the dose itself or frequency of administration remains to be determined. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Nussbaum, V., Lubcke, N., Findlay, R. Tags: Case Reports Source Type: research

Bilateral synchronous adrenal metastasis of invasive ductal carcinoma treated with multimodality therapy including adrenalectomy and oophorectomy
A 38-year-old woman presented with a mass in the left breast. Biopsy of the lesion revealed invasive ductal carcinoma. Bilateral adrenal metastasis was detected in whole body positron emission tomography scanning. Needle biopsy of the left adrenal lesion proved infiltration of malignant cells from breast carcinoma. After eight cycles of neoadjuvant (preoperative) chemotherapy, mastectomy, bilateral adrenalectomy, and bilateral oopherectomy were performed. No further hormonal treatment was recommended due to the resection of both adrenal glands and ovaries. The patient is still followed without any sign of progression. To o...
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Eren, O. O., Ordu, C., Selcuk, N. A., Akosman, C., Ozturk, M. A., Özkan, F., Gokce, O., Oyan, B. Tags: Case Reports Source Type: research

To create a cleanroom controlled environment using a mobile air decontamination unit for the preparation of antineoplastic drugs
Objectives To use a mobile air decontamination unit (MADU) for a microbial destruction and decreased particle burden making a cleanroom controlled environment in a Centralized Chemotherapy Preparation Unit (CCPU). Good manufacturing practices (GMP) in France specify that the ambient air in the vicinity of a class III biosafety cabinet (isolator) complies with air cleanliness ISO 8 level in CCPU. This guideline has a significant impact because implementing a dedicated air handling unit (AHU) brings some engineering constraints and generates substantial additional costs. Methods Authors have previously studied some technica...
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Lecordier, J., Plivard, C., Gardeux, M., Daouadi, K., Lahet, J.-J. Tags: Practice Issues Source Type: research

Worksheets with embedded checklists support IV chemotherapy safer practice
Following a review of a chemotherapy medication adverse event where the incorrect medication was prepared by a pharmacy, a number of steps were taken to review the literature and best practice information related to checking processes for the preparation of parenteral chemotherapy. Concepts such as identification of critical stop check points, independent double checks, and human factors principles were reviewed and incorporated into newly designed chemotherapy preparation worksheets with embedded checklists. Usability testing and staff feedback during implementation revealed a number of key learning points that resulted i...
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Dobish, R., Shultz, J., Neilson, S., Raven, A., Chambers, C. R. Tags: Practice Issues Source Type: research

Venous thromboembolism: What pharmacists know? What do they need?
Conclusion Training sessions on the management of venous thromboembolism in cancer are currently available to pharmacists in the region. A new assessment of knowledge will be performed at the end of the year 2014. This regional experience is now extended to a national level (all French regions). (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Rey, J.-B., Jovenin, N., Kreit, P., Sicard, J., Parent, D., Hettler, D., Nguyen, P., Ducrocq, J.-L. Tags: Practice Issues Source Type: research

A review of the evidence for occupational exposure risks to novel anticancer agents - A focus on monoclonal antibodies
Conclusion Novel agents are rapidly emerging into clinical practice, and healthcare personnel have few resources to evaluate risk and provide safety recommendations. Novel agents possess differing physical, molecular and pharmacological profiles compared to traditional cytotoxic anticancer agents. Evaluation of occupational exposure risk should consider both toxicity and internalisation. Evidence-based guidance able to direct safe handling practices for novel anticancer agents across a variety of clinical settings is urgently required. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: King, J., Alexander, M., Byrne, J., MacMillan, K., Mollo, A., Kirsa, S., Green, M. Tags: Review Articles Source Type: research

Use of naloxone for reversal of life-threatening opioid toxicity in cancer-related pain
Conclusion Opioid reversal protocols should be developed by a multi-disciplinary team. Each protocol should differentiate those toxicities which are life-threatening and require complete opioid reversal with toxicities that require small aliquots of naloxone to mitigate the presenting symptoms. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Howlett, C., Gonzalez, R., Yerram, P., Faley, B. Tags: Review Articles Source Type: research

Assessment of adherence with oral anticancer agents in oncology clinical trials: A systematic review
Conclusion This systematic review demonstrates adherence reporting in clinical trials of oral anticancer agents is infrequent. When reported, adherence was not associated with overall study quality or other study characteristics. Given the potential effects of non-adherence on study power and validity, adherence reporting should be encouraged in oncology and hematology clinical trials. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Bergsbaken, J., Eickhoff, J., Buss, B., Mably, M., Kolesar, J. Tags: Review Articles Source Type: research

A review of a novel, Brutons tyrosine kinase inhibitor, ibrutinib
Ibrutinib, a Bruton’s kinase inhibitor, was granted an accelerated approval by the US Food and Drug Administration in November, 2013, for the treatment of relapsed or refractory mantle cell lymphoma and subsequently for the treatment of relapsed refractory chronic lymphocytic leukemia in February, 2014. In the pivotal phase 2 study of 111 patients with relapsed or refractory mantle cell lymphoma, the overall response rate in patients who received ibrutinib 560 mg daily was 68%. The median progression-free survival was 13.9 months, and the overall survival was 58% at 18 months. In a recently published phase 3 trial (R...
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Lee, C.-S., Rattu, M. A., Kim, S. S. Tags: Review Articles Source Type: research

Evaluation of the stability profile of anticancer drugs: A review of Ifosfamide and Mesna regimen for the treatment of metastatic soft tissue sarcoma
Conclusion There is a need to conduct stability testing experiments for Ifosfamide and Mesna taking into consideration all of the highlighted factors to mimic standard clinical practice. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Salman, D., Swinden, J., Barton, S., Peron, J.-M. R., Nabhani-Gebara, S. Tags: Review Articles Source Type: research

Formulation of budesonide mouthwash for the treatment of oral chronic graft-versus-host disease
We describe the development of a formulation of budesonide and sodium bicarbonate for use as mouthwash in patients with oral chronic graft-versus-host disease. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Van Schandevyl, G., Bauters, T. Tags: Original Articles Source Type: research

The effect of race on the CYP3A-mediated metabolism of vincristine in pediatric patients with acute lymphoblastic leukemia
Conclusion The CYP3A5*3 genotype causes very low expression of the CYP3A5 protein and hence decreased vincristine metabolism. In this study, patients who expressed CYP3A5*3 had an increased incidence of vincristine-related neurotoxicity. Overall, a greater percentage of Caucasian patients had documented incidences of neurotoxicity. A larger sample size and more detailed gene analysis are needed for future studies. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Sims, R. P. Tags: Original Articles Source Type: research

Utilization patterns for oral oncology medications in a specialty pharmacy cycle management program
Conclusions Patient engagement and pharmacist interventions, through programs such as the CMP, are important to help patients manage these complex, high-risk medications. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Deutsch, S., Koerner, P., Miller, R. T., Craft, Z., Fancher, K. Tags: Original Articles Source Type: research

Detection and measurement of surface contamination by multiple antineoplastic drugs using multiplex bead assay
Conclusion The use of FCMIA with a simple sampling technique has potential for low cost simultaneous detection and semi-quantitative measurement of surface contamination from multiple antineoplastic drugs. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Smith, J. P., Sammons, D. L., Robertson, S. A., Pretty, J. R., DeBord, D. G., Connor, T. H., Snawder, J. E. Tags: Original Articles Source Type: research

Effectiveness and toxicity of high-dose cyclophosphamide in obese versus non-obese patients receiving allogeneic hematopoietic stem cell transplant
Conclusion Obese patients receiving high-dose Cy and allo-HCT are at increased risk for toxicity, although there appears to be no difference in the rate of relapse or survival between obese and non-obese patients. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Hunter, M. R., Sabo, R. T., McCarty, J. M., Newland, A. M. Tags: Original Articles Source Type: research