Journal of Oncology Pharmacy Practice This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A phase I study to determine the maximum tolerated dose and safety of oral LR-103 (1{alpha},24(S)Dihydroxyvitamin D2) in patients with advanced cancer
Conclusion Step A dose limiting toxicities limited accelerated dose escalation. The maximum tolerated dose of LR-103 was not reached prior to study termination and this agent is no longer being developed. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - October 25, 2015 Category: Cancer & Oncology Authors: Wisinski, K. B., Ledesma, W. M., Kolesar, J., Wilding, G., Liu, G., Douglas, J., Traynor, A. M., Albertini, M., Mulkerin, D., Bailey, H. H. Tags: Original Articles Source Type: research

Dosing algorithm for concomitant administration of sirolimus, tacrolimus, and an azole after allogeneic hematopoietic stem cell transplantation
Conclusion Dose reductions of 50–75% for both sirolimus and tacrolimus, in combination with standard dosing of azole antifungal agents, were necessary to achieve therapeutic drug concentrations for immunosuppressants and potentially avoid toxicities. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - October 25, 2015 Category: Cancer & Oncology Authors: Peksa, G. D., Schultz, K., Fung, H. C. Tags: Original Articles Source Type: research

Adherence to imatinib among patients attending Saskatchewan Cancer Agency Pharmacies
Conclusions Non-adherence to imatinib is relatively infrequent when provided by the Saskatchewan Cancer Agency. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - October 25, 2015 Category: Cancer & Oncology Authors: Dicus, M., Lyons, B., Olson, C., Tran, D. A., Blackburn, D. F. Tags: Original Articles Source Type: research

Mitomycin-based hepatic arterial infusion chemotherapy for solitary ampullary cancer liver metastasis: an unusual treatment for an uncommon disease
In conclusion, the locoregional chemotherapy administration was effective in overcoming any systemic toxicities and showed activity against the liver metastasis but it did not prevent extra-hepatic cancer dissemination. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - August 25, 2015 Category: Cancer & Oncology Authors: Vitale, F. V., Romeo, P., Luciani, B., Raffaele, M., Colina, P., Ferrau, F. Tags: Case Reports Source Type: research

Continuation of all-trans retinoic acid despite the development of scrotal ulcerations in a black male
We report this case to highlight its rarity and to note that ATRA can be continued in combination with corticosteroids throughout induction. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - August 25, 2015 Category: Cancer & Oncology Authors: Sutherland, J., Kempton, C. L., Curry, M. A. Tags: Case Reports Source Type: research

Fatal Stevens-Johnson syndrome/toxic epidermal necrolysis induced by allopurinol-rituximab-bendamustine therapy
Stevens–Johnson syndrome/toxic epidermal necrolysis overlap is an acute hypersensitivity reaction that compromises the integrity of mucous membranes and cutaneous tissue. While the pathophysiology of this syndrome has not been fully elucidated, it is commonly associated with the medication use and carries a significant mortality risk of approximately 30%. No commonalities among causative medications have been identified, and determining the offending agent can be challenging. This case report describes fatal Stevens–Johnson syndrome/toxic epidermal necrolysis overlap in a patient after receiving his first cycle...
Source: Journal of Oncology Pharmacy Practice - August 25, 2015 Category: Cancer & Oncology Authors: Fallon, M. J., Heck, J. N. Tags: Case Reports Source Type: research

Safety of inadvertent administration of overdose of intrathecal Cytarabine in a pediatric patient
Conclusion Supportive care without the need for invasive procedures such as cerebrospinal fluid exchange may be adequate for managing intrathecal Cytarabine overdose. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - August 25, 2015 Category: Cancer & Oncology Authors: Omar, S. A., Amayiri, N., Madanat, F. Tags: Case Reports Source Type: research

Hypertriglyceridemia and hyperglycemia induced by capecitabine: A report of two cases and review of the literature
Conclusion It is important of physicians and pharmacists to be aware of the possibility of dyslipidemia, particularly hypertriglyceridemia induced by capecitabine. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - August 25, 2015 Category: Cancer & Oncology Authors: Han, G.-h., Huang, J.-X. Tags: Case Reports Source Type: research

Recurrent pseudocellulitis due to gemcitabine: Underrecognized and underreported?
We report herein a case of recurrent pseudocellulitis due to gemcitabine in a patient with metastatic pancreatic cancer. We believe this condition is underreported and underrecognized. Furthermore, it may be misdiagnosed as cellulitis and inappropriately treated with systemic antibiotics. As the diagnosis is clinical and the condition is self-limited, referral to other specialists is usually not required. Awareness of gemcitabine-induced pseudocellulitis is important in order to reassure the patients, their families, and non-oncology providers and to avoid unnecessary (and often costly) diagnostic work-up. (Source: Journal...
Source: Journal of Oncology Pharmacy Practice - August 25, 2015 Category: Cancer & Oncology Authors: Dasanu, C. A., Bockorny, B. Tags: Case Reports Source Type: research

Monoclonal antibodies: Pharmacokinetics as a basis for new dosage regimens?
Complete monoclonal IgG antibodies which are in use in clinical practice share some pharmacological properties resulting in high concentrations in plasma. This fact is reflected in their low volumes of distribution, which can also be correlated with a high molecular weight and water solubility. This feature allows a novel approach to be applied to the dosing schedule for this group of drugs with fixed doses being used instead of the initially developed weight- or body surface-adjusted dosing schedules. In addition, the development of a new formulation containing hyaluronidase allows a subcutaneous route of administration t...
Source: Journal of Oncology Pharmacy Practice - August 25, 2015 Category: Cancer & Oncology Authors: Azanza, J.-R., Sadaba, B., Gomez-Guiu, A. Tags: Review Articles Source Type: research

Adenocarcinoma of the ampulla of Vater: What treatment options are available?
We describe herein a patient with ampulla of Vater adenocarcinoma who had an exceptional response to fluoropyrimidine-based chemotherapy. We further include a discussion reviewing the clinicopathologic aspects of this neoplasm as well as focus on currently available and future therapeutic options. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - August 25, 2015 Category: Cancer & Oncology Authors: Senatore, F. J., Ynson, M. L., Dasanu, C. A. Tags: Review Articles Source Type: research

Obinutuzumab for chronic lymphocytic leukemia: promise of the first treatment approved with breakthrough therapy designation
Obinutuzumab (also known as GA101, afutuzumab, Gazyva) is a humanized, glycoengineered type II monoclonal antibody targeted against CD20. The US Food and Drug Administration has approved obinutuzumab for use with chlorambucil in patients with previously untreated chronic lymphocytic leukemia. The drug is the first treatment to receive approval under the agency's breakthrough therapy designation, a program intended to facilitate and expedite the review and development of therapies for serious and life-threatening conditions. In preclinical studies, obinutuzumab has showed superior efficacy, as compared with rituximab, ...
Source: Journal of Oncology Pharmacy Practice - August 25, 2015 Category: Cancer & Oncology Authors: Kakkar, A. K., Balakrishnan, S. Tags: Review Articles Source Type: research

Feasibility of using the Multinational Association of Supportive Care in Cancer Antiemesis Tool for assessment of chemotherapy-induced nausea and vomiting at the Tom Baker Cancer Centre
Conclusion The MAT is a feasible tool which can improve communication of CINV symptoms between patients and clinicians, a foundational step toward improving CINV management. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - August 25, 2015 Category: Cancer & Oncology Authors: Warr, J. K., Chambers, C. R., Cusano, F. L., Cuthbert, C. A., Mah, M. S. Tags: Original Articles Source Type: research

Introduction of vincristine mini-bags and an assessment of the subsequent risk of extravasation
Conclusions The administration of vincristine in small volume intravenous bags was safe, practical, and feasible in all patient groups. The successful implementation of the international recommendations for vincristine administration in mini-bags to eliminate potential inadvertent intrathecal administration was dependent on stakeholder buy-in. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - August 25, 2015 Category: Cancer & Oncology Authors: Nurgat, Z., Smythe, M., Al-Jedai, A., Ewing, S., Rasheed, W., Belgaumi, A., Ahmed, S., Ashour, M., Agil, A. A., Siddiqui, K., Aljurf, M. Tags: Original Articles Source Type: research

The effects of a palliative care program on antidepressant use and continuing maintenance medications in near end-of-life oncology patients (the HEALED study)
Conclusion Quality of life is essentially the same between palliative care patients, whether they are receiving antidepressants or not. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - August 25, 2015 Category: Cancer & Oncology Authors: Thomas, H., Randolph, M., Pruemer, J. Tags: Original Articles Source Type: research