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Comparison of local reactions to oxaliplatin infusions by peripheral versus central venous administration
Conclusion This is the first published report to characterize and quantify a single institution's experience with oxaliplatin-related local reactions. A significantly greater number of local reactions, particularly pain, occurred with the administration of oxaliplatin peripherally vs. centrally. This analysis impacted our institution's best practice for oxaliplatin infusions. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - February 27, 2016 Category: Cancer & Oncology Authors: To, Y.-y., Sutcliffe, K. J., Hoen, H. M., Swaney, R. A., Nicholls, J. D., Crocenzi, T. S. Tags: Original Articles Source Type: research

Comparing venous thromboembolism prophylactic strategies for ambulatory multiple myeloma patients on immunomodulatory drug therapy
Conclusion Ambulatory patients with multiple myeloma who are considered for immunomodulatory drug therapy should be placed on pharmacologic thromboprophylaxis based on individual venous thromboembolism and bleeding risk factors. This study identified the need for increased adherence to national guidelines for venous thromboembolism prevention in patients with multiple myeloma receiving immunomodulatory drug therapy so as to increase the quality of care provided at UC Health. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - February 27, 2016 Category: Cancer & Oncology Authors: Dede, R. J., Pruemer, J. M. Tags: Original Articles Source Type: research

Risk factors for developing cardiotoxicity of trastuzumab in breast cancer patients: An observational single-centre study
Conclusion The aforementioned factors pose a risk for cardiotoxicity. We found postmenopausal status, hypertension, obesity, previous coronary artery disease and smoking to be associated with an increased risk of cardiac dysfunction in women using trastuzumab. While administering trastuzumab to women who have these conditions, one must be aware of the risk of cardiotoxicity of trastuzumab. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - February 27, 2016 Category: Cancer & Oncology Authors: Gunaldi, M., Duman, B. B., Afsar, C. U., Paydas, S., Erkisi, M., Kara, I. O., Sahin, B. Tags: Original Articles Source Type: research

Proteinuria with first-line therapy of metastatic renal cell cancer
Conclusion A high incidence of proteinuria with minor severity within each class was demonstrated. It may be reasonable to continue therapy at the same dose for Grade 1 or 2 proteinuria. Treatment modification or discontinuation of therapy may be warranted with Grade 3 or 4 proteinuria. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - February 27, 2016 Category: Cancer & Oncology Authors: Land, J. D., Chen, A. H., Atkinson, B. J., Cauley, D. H., Tannir, N. M. Tags: Original Articles Source Type: research

Tolerability and outcome of once weekly liposomal amphotericin B for the prevention of invasive fungal infections in hematopoietic stem cell transplant patients with graft-versus-host disease
Conclusion Antifungal prophylaxis with liposomal amphotericin B was well tolerated, but the incidence of invasive fungal infections in patients receiving liposomal amphotericin B was higher than other antifungal agents in this study. The optimal dose and schedule of liposomal amphotericin B for antifungal prophylaxis in this patient population are still not known and considering its broad spectrum activity, prospective trials in comparison to triazoles are warranted. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - February 27, 2016 Category: Cancer & Oncology Authors: Luu Tran, H., Mahmoudjafari, Z., Rockey, M., Henry, D., Grauer, D., Aljitawi, O., Abhyankar, S., Ganguly, S., Lin, T., McGuirk, J. Tags: Original Articles Source Type: research

A survey of manufacturing and handling practices for monoclonal antibodies by pharmacy, nursing and medical personnel
Conclusion Monoclonal antibodies are most commonly handled according to cytotoxic drug standards and often in the absence of formal guidelines. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - February 27, 2016 Category: Cancer & Oncology Authors: Alexander, M., King, J., Lingaratnam, S., Byrne, J., MacMillan, K., Mollo, A., Kirsa, S., Green, M. Tags: Original Articles Source Type: research

Assessing outcomes of adult oncology patients treated with linezolid versus daptomycin for bacteremia due to vancomycin-resistant Enterococcus
Conclusion No differences in microbiological cure, length of stay or mortality were identified between the groups. This study suggests that linezolid and daptomycin are each reasonable options for treating vancomycin-resistant Enterococcus bacteremia in oncology patients. Further prospective, randomized controlled trials are needed to assess the optimal treatment for vancomycin-resistant Enterococcus bacteremia in this patient population. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - February 27, 2016 Category: Cancer & Oncology Authors: Patel, K., Kabir, R., Ahmad, S., Allen, S. L. Tags: Original Articles Source Type: research

Abraxane(R) versus Taxol(R) for patients with advanced breast cancer: A prospective time and motion analysis from a Chinese health care perspective
Conclusion To our knowledge, this is first such study in breast cancer patients to be undertaken in China. Abraxane® was associated with fewer acute adverse drug reactions and significant reductions in health care resources, physician/nurse time and overall drug delivery costs compared to Taxol®. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - February 27, 2016 Category: Cancer & Oncology Authors: Dranitsaris, G., Yu, B., Wang, L., Sun, W., Zhou, Y., King, J., Kaura, S., Zhang, A., Yuan, P. Tags: Original Articles Source Type: research

Media-fill simulation tests in manual and robotic aseptic preparation of injection solutions in syringes
Conclusion Extensive media-fill tests simulating manual and automated preparation of ready-to-use cytotoxic injection solutions revealed the same level of sterility for both procedures. The results of supplemental environmental controls confirmed that the aseptic procedures are well controlled. As there was no difference in the microbial contamination rates of the media preparations depending on the extent of cleaning and disinfection of the robot, the results were used to adapt the respective standard operating procedures. (Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - February 27, 2016 Category: Cancer & Oncology Authors: Krämer, I., Federici, M., Kaiser, V., Thiesen, J. Tags: Original Articles Source Type: research

Successful rapid desensitization to the antibody-drug conjugate brentuximab vedotin in a patient with refractory Hodgkin lymphoma
(Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Fizesan, M., Boin, C., Aujoulat, O., Newinger, G., Ghergus, D., Watier, H., Lustig, H., Ojeda-Uribe, M. Tags: Letter to the Editor Source Type: research

Minimization of administration route errors with subcutaneous rituximab
(Source: Journal of Oncology Pharmacy Practice)
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Liptrott, S., Cambon, N., Berthillon, N., Mendoza, M., Smith, R. Tags: Letter to the Editor Source Type: research

Retroperitoneal fibrosis due to B-cell non-Hodgkin lymphoma: Responding to rituximab!
We report herein a 66-year-old patient with symptomatic retroperitoneal fibrosis leading to bilateral hydronephrosis and renal failure, in whom, after a complex diagnostic work-up and protracted clinical course, a B-cell non-Hodgkin lymphoma in the retroperitoneal space and several vertebral bodies was identified. The patient was treated with radiation therapy and weekly rituximab infusions, with resolution of hydronephrosis and lower back pain. We include a thorough literature review on etiopathogenesis, diagnosis, therapy, and prognosis of retroperitoneal fibrosis. A meticulous search for malignancy is necessary in this ...
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Alvarez Argote, J., Bauer, F. A., Posteraro, A. F., Dasanu, C. A. Tags: Case Reports Source Type: research

Dose-independent confusion induced by voriconazole in a patient with Asian ancestry after allogeneic hematopoietic stem cell transplant
This is the case of a 71-year-old man with Asian ancestry who had myelodysplastic syndrome admitted for allogeneic hematopoietic stem cell transplant. This case suggests that voriconazole-induced confusion is probably dose-independent and reversible with no residual symptoms after discontinuation of voriconazole. Patient can experience confusion even voriconazole is ordered according to package insert and serum voriconazole level is within therapeutic range (1–6 µg/mL). The onset of confusion can be delayed and sudden after seven days of voriconazole therapy. Genotyping of CYP2C19 can be tested for Asian popula...
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Hui, J. Tags: Case Reports Source Type: research

Choroid plexus papilloma--A case highlighting the challenges of extrapolating pediatric chemotherapy regimens to adult populations
We report an instance of a 40-year-old African American woman with a diagnosis of choroid plexus carcinoma admitted to the intensive care unit for severe sepsis seven days after receiving chemotherapy consisting of carboplatin (350 mg/m2 on Days 1 and 2 plus etoposide 100 mg/m2 on Days 1–5). Her laboratory results were significant for an absolute neutrophil count of 0/µL and blood cultures positive for Capnocytophagia species. She was supported with broad spectrum antibiotics and myeloid growth factors. She eventually recovered and was discharged in stable condition. The management of adults with malignancies m...
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Barman, S. L., Jean, G. W., Dinsfriend, W. M., Gerber, D. E. Tags: Case Reports Source Type: research

Acute jugular vein thrombosis during rituximab administration: Review of the literature
We report on a 22-year-old woman, who was diagnosed with stage III B CD20 positive B-cell diffuse large B-cell lymphoma. During the first cycle of treatment, she developed grand-mal seizure while receiving rituximab infusion without any other features of acute hypersensitivity reaction. Imaging confirmed new onset jugular vein thrombosis with normal coagulation parameters. These events were managed by anticonvulsants and anticoagulation therapy. The patient completed eight cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone without rituximab and achieved complete remission. No further complications were no...
Source: Journal of Oncology Pharmacy Practice - December 15, 2015 Category: Cancer & Oncology Authors: Dada, R., Zekri, J., Ramal, B., Ahmad, K. Tags: Case Reports Source Type: research