Synergistic anti-cancer effects of Timosaponin AIII and ginsenosides in MG63 human osteosarcoma cells
ConclusionsThe Results strongly suggest that the combination of TA3 and the two ginsenosides-Rb1 and -Rc may be a strong candidate for the effective anti-osteosarcoma agent. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 16, 2018 Category: Complementary Medicine Source Type: research
The adventure of a lifetime: kids, entertainment, and an endangered root
Publication date: Available online 26 October 2018Source: Journal of Ginseng ResearchAuthor(s): George Lindemann (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 14, 2018 Category: Complementary Medicine Source Type: research
Compound K, a ginsenoside metabolite, plays an antiinflammatory role in macrophages by targeting the AKT1-mediated signaling pathway
ConclusionOur results suggest that CK plays an antiinflammatory role during macrophage-mediated inflammatory actions by specifically targeting the AKT1-mediated signaling pathway. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 14, 2018 Category: Complementary Medicine Source Type: research
Identification of a novel triterpene saponin from Panax ginseng seeds, pseudoginsenoside RT8, and its anti-inflammatory activity
ConclusionsThese findings indicate that pseudoginsenoside RT8 has a pharmaceutical potential as an anti-inflammatory agent and P. ginseng seeds are a good natural source for discovering novel bioactive molecules. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 11, 2018 Category: Complementary Medicine Source Type: research
Ginsenoside Rg5 overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter: in vitro and in vivo study
ConclusionTherefore, combination therapy of Rg5 and chemotherapy drugs is a strategy for the adjuvant chemotherapy, which encourages further pharmacokinetic and clinical studies. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 9, 2018 Category: Complementary Medicine Source Type: research
Acute and repeated dose 26-week oral toxicity study of 20(S)-ginsenoside Rg3 in Kunming mice and Sprague–Dawley rats
ConclusionThe mean oral lethal dose (LD50) of 20(S)-ginsenoside Rg3, in acute toxicity, is above 1600 mg/kg and 800 mg/kg in mice and rats, respectively. In a repeated-dose 26-week oral toxicity study, the no-observed-adverse-effect level for female and male SD rats was 180 mg/kg. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 6, 2018 Category: Complementary Medicine Source Type: research
Putative multiple reaction monitoring strategy for the comparative pharmacokinetics of postoral administration Renshen–Yuanzhi compatibility through liquid chromatography–tandem mass spectrometry
ConclusionResults indicated that Traditional Chinese Medicine combinations can produce synergistic effects and diminish possible toxic effects, thereby reflecting the advantages of compatibility. The proposed strategy can solve the quantitative problem of LRS and extend the scopes of PK studies. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 27, 2018 Category: Complementary Medicine Source Type: research
Tolerability and pharmacokinetics of ginsenosides Rb1, Rb2, Rc, Rd, and compound K after single or multiple administration of Red ginseng extract in human subjects
ConclusionA good correlation between the AUC values of Rd and compound K might be the result of intestinal biotransformation of Rb1, Rb2, and Rc to Rd and subsequently to compound K, rather than the intestinal permeability of these ginsenosides. A strategy to increase biotransformation or reduce metabolic inter-subject variability may increase the plasma concentrations of Rd and compound K. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 27, 2018 Category: Complementary Medicine Source Type: research
Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis and insulin resistance in mice
ConclusionGBHT prevents changes in lipid and carbohydrate metabolism in a high-fat diet mouse model. Our findings provide evidence for the traditional use of GBHT as therapy for the management of metabolic syndrome. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 27, 2018 Category: Complementary Medicine Source Type: research
Compound K, a ginsenoside metabolite, plays an anti-inflammatory role in macrophages by targeting the AKT1-mediated signaling pathway
ConclusionOur results suggest that CK plays an anti-inflammatory role during macrophage-mediated inflammatory actions by specifically targeting the AKT1-mediated signaling pathway. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 27, 2018 Category: Complementary Medicine Source Type: research
The Adventure of a Lifetime: Kids, Entertainment and an Endangered Root
Publication date: Available online 26 October 2018Source: Journal of Ginseng ResearchAuthor(s): George Lindemann (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 26, 2018 Category: Complementary Medicine Source Type: research
Panax ginseng: A candidate herbal medicine for autoimmune disease
Publication date: Available online 26 October 2018Source: Journal of Ginseng ResearchAuthor(s): Joon-Il Lee, Ik-Hyun ChoAbstractPanax ginseng Meyer (P. ginseng; Korean ginseng) is well known for its medicinal properties. It can alleviate pathological symptoms, promote health, and prevent potential diseases via its anti-inflammatory, anti-oxidant, homeostatic, and other positive effects on biological metabolism. Although many studies have determined effects of P. ginseng on various diseases such as cardiovascular, neurological, and immunological diseases, little is known about the effect of P. ginseng on autoimmune diseases...
Source: Journal of Ginseng Research - October 26, 2018 Category: Complementary Medicine Source Type: research
Two new triterpenoid saponins derived from the leaves of Panax ginseng and their antiinflammatory activity
Publication date: Available online 4 October 2018Source: Journal of Ginseng ResearchAuthor(s): Fu Li, Yufeng Cao, Yanyan Luo, Tingwu Liu, Guilong Yan, Liang Chen, Lilian Ji, Lun Wang, Bin Chen, Aftab Yaseen, Ashfaq A. Khan, Guolin Zhang, Yunyao Jiang, Jianxun Liu, Gongcheng Wang, Ming-Kui Wang, Weicheng HuAbstractBackgroundThe leaves and roots of Panax ginseng are rich in ginsenosides. However, the chemical compositions of the leaves and roots of P. ginseng differ, resulting in different medicinal functions. In recent years, the aerial parts of members of the Panax genus have received great attention from natural product c...
Source: Journal of Ginseng Research - October 23, 2018 Category: Complementary Medicine Source Type: research
Acute and repeated-dose 26-week oral toxicity study of 20(S)-ginsenoside Rg3 in Kunming mice and Sprague-Dawley rats
ConclusionThe mean oral lethal dose (LD50) of 20(S)-ginsenoside Rg3, in acute toxicity, is above 1600 mg/kg and 800 mg/kg in mice and rats, respectively. In a repeated-dose 26-week oral toxicity study, the no observed adverse effect level (NOAEL) for female and male SD rats was 180 mg/kg. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 20, 2018 Category: Complementary Medicine Source Type: research
Production of bioactive ginsenoside Rg3(S) and compound K using recombinant Lactococcus lactis
ConclusionThis study demonstrates that the lactic acid bacteria having specific β-glucosidase activity can be used to enhance the health benefits of Panax ginseng in either fermented foods or bioconversion processes. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 12, 2018 Category: Complementary Medicine Source Type: research
