Oleanolic acid 3-acetate, a minor element of ginsenosides, induces apoptotic cell death in ovarian carcinoma and endometrial carcinoma cells via the involvement of a reactive oxygen species-independent mitochondrial pathway
ConclusionThese findings support the notion that oleanolic acid 3-acetate could be used as a potent anti-cancer supplementary agent against ovarian and endometrial cancer. Oleanolic acid 3-acetate exerts their proapoptotic effects through a rather unique molecular mechanism that involves an unconventional ROS-independent but mitochondria-mediated pathway. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - September 20, 2018 Category: Complementary Medicine Source Type: research
Ginsenoside Rb1 exerts neuroprotective effects through regulation of Lactobacillus helveticus abundance and GABAA receptor expression
Publication date: Available online 19 September 2018Source: Journal of Ginseng ResearchAuthor(s): Huimin Chen, Jiajia Shen, Haofeng Li, Xiao Zheng, Dian Kang, Yangfan Xu, Chong Chen, Huimin Guo, Lin Xie, Guangji Wang, Yan LiangAbstractBackgroundAs one of the most abundant protopanaxadiol-type ginsenosides, ginsenoside Rb1 (Rb1) exerts excellent neuroprotective effects even though it has low intracephalic exposure.PurposeThe present study aimed to elucidate the apparent contradiction between the pharmacokinetics and pharmacodynamics of Rb1 by studying the mechanisms underlying neuroprotective effects of Rb1 based on regulat...
Source: Journal of Ginseng Research - September 20, 2018 Category: Complementary Medicine Source Type: research
Studies of the effects and mechanisms of ginsenoside Re and Rk3 on myelosuppression induced by cyclophosphamide
ConclusionRe and Rk3 could improve the hematopoietic function of myelosuppressed mice. The effect of Rk3 was superior to that of Re at any dose. Regulating the levels of cytokines, promoting cells enter the normal cell cycle, regulating the balance of bcl-2/bax, and inhibiting the expression of caspase-3 may be the effects of Re and Rk3 on myelosuppression. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - September 18, 2018 Category: Complementary Medicine Source Type: research
Ginsenosides: The need to move forward from bench to clinical trials
Publication date: Available online 7 September 2018Source: Journal of Ginseng ResearchAuthor(s): Seung Eun Yu, Benjamin Mwesige, Young-Su Yi, Byong Chul YooAbstractPanax ginseng, known as Koran ginseng, one of the most commonly used traditional plants, has been demonstrated to show a wide range of pharmacological applications. Ginsenosides is the major active ingredients found in ginseng and is responsible for the biological and pharmacological activities, such as anti-oxidation, anti-inflammation, vasorelaxation, and anti-cancer actions. Existing studies have mostly focused on identifying and purifying single ginsenosides...
Source: Journal of Ginseng Research - September 8, 2018 Category: Complementary Medicine Source Type: research
Effects and mechanisms of ginsenoside re and its secondary metabolite ginsenoside rk3 on myelosuppression
ConclusionRe and Rk3 could improve the hematopoietic function of myelosuppression mice. The effect of Rk3 was superior to Re at any does. Regulating the level of cytokines, promoting cells enter the normal cell cycle and regulating the balance of bcl-2/bax and inhibiting the expression of caspase-3 may be the mechanisms of Re and Rk3 on myelosuppression. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - August 31, 2018 Category: Complementary Medicine Source Type: research
