20(S)-ginsenoside Rh2 displays efficacy against T-cell acute lymphoblastic leukemia through PI3K/Akt/mTOR signal pathway
ConclusionThe findings indicate that 20(S)-GRh2 exhibits beneficial effects against T-ALL through PI3K/Akt/mTOR pathway and could be a natural product of novel target for T-ALL therapy.Graphical abstract20(S)-ginsenoside Rh2 (20(S)-GRh2) is a major active compound extracted from ginseng, which exhibits anti-cancer effects. In this study, we explored the anti-leukemia effect of 20(S)-GRh2 in vitro and in vivo. Furthermore, the underlying molecular mechanisms of 20(S)-GRh2 against T-ALL were investigated. Our results showed that 20(S)-GRh2 inhibited cell proliferation and arrested cell cycle at G1 phase through inhibiting PI...
Source: Journal of Ginseng Research - July 30, 2019 Category: Complementary Medicine Source Type: research
Simultaneous quantification of six non-polar ginsenosides in white ginseng by reverse-phase high-performance liquid chromatography coupled with integrated pulsed amperometric detection
ConclusionIt was confirmed that non-polar ginsenosides known to be specific components of red ginseng were present at substantial concentrations in the HR or RH of white ginseng.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - July 27, 2019 Category: Complementary Medicine Source Type: research
AKT1-targeted proapoptotic activity of compound K in human breast cancer cells
ConclusionOur results suggest that CK could be used as a therapeutic compound for breast cancer.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - July 26, 2019 Category: Complementary Medicine Source Type: research
Antiarrhythmic effects of ginsenoside Rg2 on calcium chloride–induced arrhythmias without oral toxicity
ConclusionOur findings support the development of Rg2 as a promising antiarrhythmic drug with fewer side effects for clinical use. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - July 10, 2019 Category: Complementary Medicine Source Type: research
The G115 standardized ginseng extract: an example for safety, efficacy, and quality of an herbal medicine
Publication date: Available online 18 June 2019Source: Journal of Ginseng ResearchAuthor(s): Anna R. Bilia, Maria C. BergonziAbstractGinseng products on the market show high variability in their composition and overall quality. This becomes a challenge for both consumers and health-care professionals who are in search of high-quality, reliable ginseng products that have a proven safety and efficacy profile. The botanical extract standardization is of crucial importance in this context as it determines the reproducibility of the quality of the product that is essential for the evaluation of effectiveness and safety. This re...
Source: Journal of Ginseng Research - July 5, 2019 Category: Complementary Medicine Source Type: research
Biotransformation of natural polyacetylene in red ginseng by Chaetomium globosum
ConclusionMetabolite A is a rare example of natural polyacetylene biotransformation by microbial fermentation. This biotransformation only occurred in fermented RG. The extract of RG also stimulated the production of a new natural product, cazaldehyde B, from C. globosum. The lactone in metabolite A can decrease the cytotoxicity, which was deemed to be the intrinsic activity of polyacetylene in ginseng.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - July 5, 2019 Category: Complementary Medicine Source Type: research
Cold-induced Ginsenosides Accumulation is Associated with the Alteration in DNA Methylation and Relative Gene Expression in Perennial American Ginseng (Panax quinquefolium L.) along with its Plant Growth and Development Process
ConclusionWe therefore hypothesized that cold-induced DNA methylation changes might regulate relative gene expression involving both plant development and plant secondary metabolites in such cold dependent perennial plant species.Graphical abstractA postulated mechanism of cold-induced ginsenosides accumulation in perennial American ginseng Along with the seasonal changes in temperature, the 1 to 2-year-old American ginseng, which are at the stage of plant vegetative growth, experience DNA demethylation, a lower levels expression of PqDDS, a small quantity of ginsenosides accumulation and then plant aerial parts wilted and...
Source: Journal of Ginseng Research - July 2, 2019 Category: Complementary Medicine Source Type: research
Effects of a gintonin-enriched fraction on hair growth: an in vitro and in vivo study
ConclusionTopical application of GEF promotes mouse hair growth through HFDPC proliferation. GEF could be one of the main components of ginseng that promote hair growth and could be used to treat human alopecia. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - June 26, 2019 Category: Complementary Medicine Source Type: research
Korean Red Ginseng increases defective pol gene in peripheral blood mononuclear cells of HIV-1–infected patients; inhibition of its detection during ginseng-based combination therapy
ConclusionThe proportion of Δpol depends on template size as well as KRG treatment. HAART decreases the detection of Δpol. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - June 24, 2019 Category: Complementary Medicine Source Type: research
Anti-arrhythmic Effects of Ginsenoside Rg2 on Calcium Chloride-induced Arrhythmias without Oral Toxicity
ConclusionOur findings support the development of Rg2 as a promising anti-arrhythmic drug with less side effects for clinic use.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - June 24, 2019 Category: Complementary Medicine Source Type: research
Till 2018: A Survey of Biomolecule Sequences in Genus Panax
Publication date: Available online 20 June 2019Source: Journal of Ginseng ResearchAuthor(s): Vinothini Boopathi, Sathiyamoorthy Subramaniyam, Ramya Mathiyalagan, Deok-Chun YangAbstractGinseng is popularly known to be the king of ancient medicines and is used widely in most of the traditional medicinal compositions due to its various pharmaceutical properties. Numerous studies are being focused on this plant's remedial/curative effects to discover their potential health benefits in most human diseases, including cancer - the most life-threatening disease worldwide. Modern pharmacological research has focused mainly on ginse...
Source: Journal of Ginseng Research - June 21, 2019 Category: Complementary Medicine Source Type: research
Anti-platelet role of Korean ginseng and ginsenosides in cardiovascular diseases
Publication date: Available online 21 May 2019Source: Journal of Ginseng ResearchAuthor(s): Muhammad Irfan, Minki Kim, Man Hee RheeAbstractCardiovascular diseases prevail among modern societies and underdeveloped countries, and a high mortality rate has also been reported by the World Health Organization affecting millions of people worldwide. Hyperactive platelets are the major culprits in thrombotic disorders. A group of drugs is available to deal with such platelet-related disorders; however, sometimes, side effects and complications caused by these drugs outweigh their benefits. Ginseng and its nutraceuticals have been...
Source: Journal of Ginseng Research - June 20, 2019 Category: Complementary Medicine Source Type: research
Quinetides: diverse posttranslational modified peptides of ribonuclease-like storage protein from Panax quinquefolius as markers for differentiating ginseng species
ConclusionWe provide specific information on PQ peptides and propose the clinical application of peptide markers to distinguish PQ from P. ginseng. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - June 18, 2019 Category: Complementary Medicine Source Type: research
The G115 standardized ginseng extract: an example for safety, efficacy and quality of an herbal medicine
Publication date: Available online 18 June 2019Source: Journal of Ginseng ResearchAuthor(s): Anna Rita Bilia, Maria Camilla BergonziAbstractGinseng products on the market show high variability in their composition and overall quality. This becomes a challenge for both consumers and health care professionals who are in search of high-quality, reliable ginseng products that have a proven safety and efficacy profile. The botanical extract standardization is of crucial importance in this context as it determines the reproducibility of the quality of the product which is essential for the evaluation of effectiveness and safety....
Source: Journal of Ginseng Research - June 18, 2019 Category: Complementary Medicine Source Type: research
Ginsenoside Rh2 attenuates microglial activation against toxoplasmic encephalitis via TLR4/NF-κB signaling pathway
Publication date: Available online 14 June 2019Source: Journal of Ginseng ResearchAuthor(s): Xiang Xu, Lan Jin, Tong Jiang, Ying Lu, Fumie Aosai, Hu-Nan Piao, Guang-Hua Xu, Cheng-Hua Jin, Xue-Jun Jin, Juan Ma, Lian-Xun PiaoAbstractBackgroundGinsenoside Rh2 (GRh2) is a characterized component in red ginseng widely used in Korea and China. GRh2 exhibits a wide range of pharmacological activities, such as anti-inflammatory, anti-oxidant and anti-cancer properties. However, its effects on Toxoplasma gondii (T. gondii) infection have not been clarified yet.MethodsThe effect of GRh2 against T. gondii was assessed under in vitro ...
Source: Journal of Ginseng Research - June 14, 2019 Category: Complementary Medicine Source Type: research
