Ginsenoside Rg3 protects against iE-DAP–induced endothelial-to-mesenchymal transition by regulating the miR-139-5p–NF-κB axis
ConclusionThese results suggest, for the first time, that Rg3 can be used to inhibit inflammation-induced EndMT and may be a novel therapeutic option against EndMT-associated vascular diseases. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - March 8, 2019 Category: Complementary Medicine Source Type: research
Fermented red ginseng and ginsenoside Rd alleviate ovalbumin-induced allergic rhinitis in mice by suppressing IgE, IL-4, and IL-5 expression
Conclusion: fRG and ginsenoside Rd may alleviate AR by suppressing IgE, IL-4, IL-5, and IL-13 expression and restoring the composition of gut microbiota. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - March 8, 2019 Category: Complementary Medicine Source Type: research
Protein Target Identification of Ginsenosides in Skeletal Muscle Tissues: Discovery of Natural Small-Molecule Activators of Muscle-Type Creatine Kinase
ConclusionOur results suggest a cellular target and an initiating molecular event by which ginseng reduces fatigue. All these findings indicate PPD as a small-molecular activator of CK-MM, which can help in further developing better CK-MM activators based on the dammarane-type triterpenoid structure. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - March 8, 2019 Category: Complementary Medicine Source Type: research
Stem-leaf saponins from Panax notoginseng counteract aberrant autophagy and apoptosis in hippocampal neurons of mice with cognitive impairment induced by sleep deprivation
ConclusionSLSP could alleviate cognitive impairment induced by SD, which was achieved probably through suppressing the abnormal autophagy and apoptosis of hippocampal neurons. The findings may contribute to the clinical application of SLSP in the prevention or therapy of neurological disorders associated with SD. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - March 1, 2019 Category: Complementary Medicine Source Type: research
Panax ginseng derived fraction BIOGF1K reduces atopic dermatitis responses via suppression of mitogen-activated protein kinase signaling pathway
ConclusionsBIOGF1K attenuated the AD response, hence supporting its use as a promising and natural approach for treating AD. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - March 1, 2019 Category: Complementary Medicine Source Type: research
Ginsenoside Rg3 and Korean red ginseng extract epigenetically regulate the tumor-related long noncoding RNAs RFX3-AS1 and STXBP5-AS1
ConclusionThe current study is the first to identify lncRNAs that are regulated by the presence of Rg3 and KRG extract and that subsequently contribute to inhibiting the proliferation of cancer cells. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - March 1, 2019 Category: Complementary Medicine Source Type: research
Pathogenesis Strategies and Regulation of Ginsenosides by Two Species of Ilyonectria in Panax ginseng: Power of Speciation
ConclusionInfection by the weakly aggressive I. robusta led to the upregulation of ginsenoside production and biosynthesis, probably because only a low level of ROS was induced. In contrast, the more aggressive I. mors-panacis suppressed ginsenoside biosynthesis, probably because of higher ROS levels and subsequent induction of programmed cell death pathways. Furthermore, I. mors-panacis may have increased its virulence by resisting the cytotoxicity of ROS. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 20, 2019 Category: Complementary Medicine Source Type: research
Unraveling dynamic metabolomes underlying different maturation stages of berries harvested from Panax ginseng
ConclusionsComprehending the dynamic metabolic variations associated with GB maturation stages rationalize their optimal harvest time per se the related agro-economic traits. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 20, 2019 Category: Complementary Medicine Source Type: research
Advances in the chemistry, pharmacological diversity, and metabolism of 20(R)-ginseng saponins
In this study, the discovery, identification, chemical epimerization, microbial transformation, pharmacological activities, and metabolism of 20(R)-ginseng saponins are summarized. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 17, 2019 Category: Complementary Medicine Source Type: research
Ginsenoside Rb1 and Rb2 upregulate Akt/mTOR signaling–mediated muscular hypertrophy and myoblast differentiation
ConclusionRb1 and Rb2 upregulate myotube growth and myogenic differentiation through activating Akt/mammalian target of rapamycin signaling and inducing myogenic conversion of fibroblasts. Thus, our first finding indicates that Rb1 and Rb2 have strong potential as a helpful remedy to prevent and treat muscle atrophy, such as age-related muscular dystrophy. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 17, 2019 Category: Complementary Medicine Source Type: research
A randomized, double-blind, placebo-controlled pilot study to assess the effects of protopanaxadiol saponin-enriched ginseng extract and pectinase-processed ginseng extract on the prevention of acute respiratory illness in healthy people
ConclusionsThe results support the feasibility of a full-scale trial. GS-3K8 and GISNT appear to have a positive tendency towards preventing the development of ARI and reducing the symptom duration. A randomized controlled trial is needed to confirm these findings. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 12, 2019 Category: Complementary Medicine Source Type: research
Ginsenoside Rg3 protects against γ-d-glutamyl-meso-diaminopimelic acid–induced endothelial-to-mesenchymal transition by regulating the miR-139-5p–NF-κB axis
ConclusionThese results suggest, for the first time, that Rg3 can be used to inhibit inflammation-induced EndMT and may be a novel therapeutic option against EndMT-associated vascular diseases. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 7, 2019 Category: Complementary Medicine Source Type: research
New hydroperoxylated and 20,24-epoxylated dammarane triterpenes from the rot roots of Panax notoginseng
ConclusionThirty dammarane-type triterpenes and saponins were isolated from the rot roots of P. notoginseng. Among them, seven triterpenes, namely 20(S)-dammar-25-ene-24(S)-hydroperoxyl-3β,6α,12β,20-tetrol (1), 20(S)-dammar-3-oxo-23-ene-25-hydroperoxyl-6α,12β,20-triol (2), 20(S)-dammar-12-oxo-23-ene-25-hydroperoxyl-3β,6α,20-triol (3), 20(S)-dammar-3-oxo-23-ene-25-hydroperoxyl-12β,20-diol (4), 20(S),24(R)-epoxy-3,4-seco-dammar-25-hydroxy-12-one-3-oic acid (5), 20(S),24(R)-epoxy-3,4-seco-dammar-25-hydroxy-12-one-3-oic acid methyl ester (6), and 6α-hydroxy-22,23,24,25,26,27-hexanordammar-3,12,20-trione (7) are new co...
Source: Journal of Ginseng Research - February 7, 2019 Category: Complementary Medicine Source Type: research
Stem-leaf saponins from Panax notoginseng counteracts aberrant autophagy and apoptosis in hippocampal neurons of mice with cognitive impairment induced by sleep deprivation
Conclusion SLSP could alleviate cognitive impairment induced by SD, which was achieved probably through suppressing the abnormal autophagy and apoptosis of hippocampal neurons. The findings may contribute to the clinical application of SLSP in the prevention or therapy of neurological disorders associated with sleep deprivation. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 7, 2019 Category: Complementary Medicine Source Type: research
Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis
ConclusionThese results show that G-LLA herb pair might produce synergistic or complementary compatibility effects on bone marrow suppression after chemotherapy. It suggests that the substance basis of G-LLA for treating bone marrow suppression may be effective chemical components. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 6, 2019 Category: Complementary Medicine Source Type: research
