The non-saponin fraction of Korean red ginseng (KGC05P0) decreases glucose uptake and transport in vitro and modulates glucose production via down-regulation of the PI3K/AKT pathway in vivo
ConclusionOur study thereby demonstrated that KGC05P0 exerted anti-diabetic effects through inhibition of glucose absorption and the PI3K/AKT pathway in in vitro and in vivo models of diabetes. Our results suggest that KGC05P0 could be developed as a complementary food to help prevent T2DM and its complications. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 7, 2020 Category: Complementary Medicine Source Type: research
Anti-tumor activities of Panax quinquefolius saponins and potential biomarkers in prostate cancer
ConclusionPQS promoted cells apoptosis and inhibited the proliferation of DU145 cells, which suggests that PQS may be effective for treating PC. TMEM79 and ACOXL were expressed significantly higher in PNT2 than in DU145 cells and could be novel biomarker candidates for PC diagnosis.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 7, 2020 Category: Complementary Medicine Source Type: research
Siderophore-producing rhizobacteria reduce heavy metal-induced oxidative stress in Panax ginseng Meyer
ConclusionsIt was confirmed that SPR DCY119T can potentially be used for bioremediation of heavy metal contamination.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 7, 2020 Category: Complementary Medicine Source Type: research
Gintonin facilitates brain delivery of donepezil, a therapeutic drug for Alzheimer disease, through lysophosphatidic acid 1/3 and vascular endothelial growth factor receptors
ConclusionsWe found that intravenous, but not oral, coadministration of gintonin facilitates brain delivery of DPZ from plasma via LPA1/3 and VEGF receptors. Gintonin is a potential candidate as a ginseng-derived novel agent for the brain delivery of DPZ for treatment of patients with AD. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 1, 2020 Category: Complementary Medicine Source Type: research
Regulatory roles of ginseng on inflammatory caspases, executioners of inflammasome activation
Publication date: Available online 24 December 2019Source: Journal of Ginseng ResearchAuthor(s): Miyong Yun, Young-Su YiAbstractInflammation is an immune response that protects against pathogens and cellular stress. The hallmark of inflammatory responses is inflammasome activation in response to various stimuli. This subsequently activates downstream effectors, i.e., inflammatory caspases such as caspase-1, 4, 5, 11, and 12. Extensive efforts have been made on developing effective and safe anti-inflammatory therapeutics, and ginseng has long been traditionally utilized as efficacious and safe herbal medicine in treating va...
Source: Journal of Ginseng Research - December 24, 2019 Category: Complementary Medicine Source Type: research
Oral administration of hydrolyzed red ginseng extract improves learning and memory capability of scopolamine-treated C57BL/6J mice via upregulation of Nrf2-mediated antioxidant mechanism
ConclusionThese findings suggest that HRGE administration can effectively alleviate hippocampus-mediated cognitive impairment, possibly through cytoprotective mechanisms, preventing oxidative stress-induced neuronal cell death via the upregulation of phase 2 antioxidant molecules.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 21, 2019 Category: Complementary Medicine Source Type: research
Ginsenosides: potential therapeutic source for fibrosis-associated human diseases
In this report, our aim was to focus on the therapeutic prospects of ginsenosides in fibrosis-related human diseases making use of results acquired from various animal models. These findings should provide important therapeutic clues and strategies for the exploration of new drugs for fibrosis treatment.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 18, 2019 Category: Complementary Medicine Source Type: research
The non-saponin fraction of Korean Red Ginseng (KGC05P0) decreases glucose uptake and transport in vitro and modulates glucose production via down-regulation of the PI3K/AKT pathway in vivo.
ConclusionOur study thereby demonstrated that KGC05P0 exerted anti-diabetic effects through inhibition of glucose absorption and the PI3K/AKT pathway in in vitro and in vivo models of diabetes. Our results suggest that KGC05P0 could be developed as a complementary food to help prevent T2DM and its complications. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 18, 2019 Category: Complementary Medicine Source Type: research
Gintonin facilitates brain delivery of donepezil, a therapeutic drug for Alzheimer’s disease, through LPA1/3 and VEGF receptors
ConclusionsWe found that intravenous, but not oral, administration of gintonin facilitates brain delivery of donepezil from plasma via LPA1/3 and VEGF receptors. Gintonin is a potential candidate as a ginseng-derived novel agent for the brain delivery of donepezil for treatment of the AD brain.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 18, 2019 Category: Complementary Medicine Source Type: research
Ginseng alleviates microbial infections of the respiratory tract: A review
Publication date: Available online 12 December 2019Source: Journal of Ginseng ResearchAuthor(s): Hamid Iqbal, Dong-kwon RheeAbstractThe detrimental impact of air pollution as a result of frequent exposure to fine particles posed a global public health risk mainly to the pulmonary disorders in pediatric and geriatric population. Here we reviewed the current literature regarding the role of ginseng and/or its components as antimicrobials, especially against pathogens that cause respiratory infections in animal and in vitro models. Some of the possible mechanisms for ginseng-mediated viral inhibition may be improvements in sy...
Source: Journal of Ginseng Research - December 13, 2019 Category: Complementary Medicine Source Type: research
Acremonidin E produced by Penicillium sp. SNF123, a fungal endophyte of Panax ginseng, has antimelanogenic activities
ConclusionThis study demonstrates that acremonidin E, a bioactive metabolite derived from a fungal endophyte of P. ginseng, can inhibit melanin synthesis by downregulating tyrosinase, illuminating the potential utility of microorganisms associated with P. ginseng for cosmetic ingredients. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 9, 2019 Category: Complementary Medicine Source Type: research
Gastroprotective effects of the nonsaponin fraction of Korean red ginseng through cyclooxygenase-1 upregulation
ConclusionThese results suggest that NSF has gastroprotective effects on gastritis and colitis in in vivo mouse models through COX-1 upregulation. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 6, 2019 Category: Complementary Medicine Source Type: research
Gypenoside XVII protects against myocardial ischemia and reperfusion injury by inhibiting ER stress–induced mitochondrial injury
ConclusionGP-17 inhibits I/R-induced mitochondrial injury by delaying the onset of ER stress through the PI3K/AKT and P38 signaling pathways. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 3, 2019 Category: Complementary Medicine Source Type: research
Effect of coadministration of enriched Korean red ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial
ConclusionCoadministration of Rg3-KRG + AG is an effective addon for improving BP along with attaining favorable cardiometabolic outcomes in individuals with type 2 diabetes. Ginseng derivatives may offer clinical utility when included in the polypharmacy and lifestyle treatment of diabetes.Clinical trial registrationClinicaltrials.gov identifier, NCT01578837; (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 2, 2019 Category: Complementary Medicine Source Type: research
Korean Red Ginseng reduces chronic social defeat stress-induced mood disorders via N-methyl-D-aspartate receptor modulation in mice
ConclusionThese results indicate that KRG has a therapeutic effect on CSDS-induced mood disorder by alleviating N-methyl-D-aspartate receptor overexpression in the hippocampus. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 26, 2019 Category: Complementary Medicine Source Type: research
