Biotransformation of natural polyacetylene in red ginseng by Chaetomium globosum

ConclusionMetabolite A is a rare example of natural polyacetylene biotransformation by microbial fermentation. This biotransformation only occurred in fermented RG. The extract of RG also stimulated the production of a new natural product, cazaldehyde B, from C. globosum. The lactone in metabolite A can decrease the cytotoxicity, which was deemed to be the intrinsic activity of polyacetylene in ginseng.Graphical abstract
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research