Tolerability and pharmacokinetics of ginsenosides Rb1, Rb2, Rc, Rd, and compound K after single or multiple administration of Red ginseng extract in human subjects

ConclusionA good correlation between the AUC values of Rd and compound K might be the result of intestinal biotransformation of Rb1, Rb2, and Rc to Rd and subsequently to compound K, rather than the intestinal permeability of these ginsenosides. A strategy to increase biotransformation or reduce metabolic inter-subject variability may increase the plasma concentrations of Rd and compound K.
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research