Effect of Cognitive Status on Self-Regulatory Driving Behavior in Older Adults: An Assessment of Naturalistic Driving Using In-Car Video Recordings
This study analyzed in-car video recording of naturalistic driving of 18 patients with Alzheimer disease (AD) and 20 age-matched controls in order to (1) characterize self-regulatory behaviors engaged by older drivers and (2) assess how behaviors change with cognitive impairment. Only participants who were rated "safe" on a prior standardized road test were selected for this study. Both groups drove primarily in environments that minimized the demands on driving skill and that incurred the least risk for involvement in major crashes. Patients with AD displayed further restrictions of driving behavior beyond those of health...
Source: Journal of Geriatric Psychiatry and Neurology - March 20, 2013 Category: Genetics & Stem Cells Authors: Festa, E. K., Ott, B. R., Manning, K. J., Davis, J. D., Heindel, W. C. Tags: Articles Source Type: research

Clinical Phenomenology and Mortality in Charles Bonnet Syndrome
Conclusions: A large proportion of patients with CBS developed dementia, and there was a high mortality rate associated with older age and renal disease. Medical burden was not associated with mortality. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - March 20, 2013 Category: Genetics & Stem Cells Authors: Lapid, M. I., Burton, M. C., Chang, M. T., Rummans, T. A., Cha, S. S., Leavitt, J. A., Boeve, B. F. Tags: Articles Source Type: research

Pain in People With Alzheimer Disease: Potential Applications for Psychophysical and Neurophysiological Research
Pain management in people with dementia is a critical problem. Recently, psychophysical and neuroimaging techniques have been used to extend our understanding of pain processing in the brain as well as to identify structural and functional changes in Alzheimer disease (AD). But interpreting the complex relationship between AD pathology, brain activation, and pain reports is challenging. This review proposes a conceptual framework for designing and interpreting psychophysical and neuroimaging studies of pain processing in people with AD. Previous human studies describe the lateral (sensory) and medial (affective) pain netwo...
Source: Journal of Geriatric Psychiatry and Neurology - January 11, 2013 Category: Genetics & Stem Cells Authors: Monroe, T. B., Gore, J. C., Chen, L. M., Mion, L. C., Cowan, R. L. Tags: Articles Source Type: research

Anxiety Disorders, Physical Illnesses, and Health Care Utilization in Older Male Veterans With Parkinson Disease and Comorbid Depression
This study examined the rates of anxiety and depressive disorders, physical illnesses, and health service use in male patients 55 years or older with a diagnosis of Parkinson disease who were seen at least twice at the 10 medical centers in the Veterans Affairs Healthcare Network of the South Central region of the United States. Of the 273 male patients diagnosed between October 1, 1997, and September 30, 2009, 62 (22.7%) had a depressive disorder. The overall prevalence of anxiety disorders was 12.8%; patients with comorbid depression had a 5-fold greater prevalence of anxiety disorders than those without depression (35.5...
Source: Journal of Geriatric Psychiatry and Neurology - January 11, 2013 Category: Genetics & Stem Cells Authors: Qureshi, S. U., Amspoker, A. B., Calleo, J. S., Kunik, M. E., Marsh, L. Tags: Articles Source Type: research

The Informant Questionnaire on Cognitive Decline in the Elderly Individuals in Screening Mild Cognitive Impairment With or Without Functional Impairment
In this study, we investigate the utility of the IQCODE for patients with mild cognitive impairment (MCI) and the discriminative power of the IQCODE in patients having MCI with and without functional impairment. The samples included mild Alzheimer disease (AD, N = 280), MCI ([N = 657], further divided into 2 subgroups: patients with MCI having functional impairment [MCI-fi, N = 357] and patients having MCI without functional impairment [MCI-fn, N = 300]), and normal cognition (NC, N = 274). The IQCODE, Mini-Mental State Examination (MMSE), and other neuropsychological tests were administered to all participants. Logistic r...
Source: Journal of Geriatric Psychiatry and Neurology - January 11, 2013 Category: Genetics & Stem Cells Authors: Li, F., Jia, X.-F., Jia, J. Tags: Articles Source Type: research

Caregiver Burden in Parkinson Disease With Dementia Compared to Alzheimer Disease in Korea
We compared caregiver burden in Parkinson disease with dementia (PDD) to that in Alzheimer disease (AD) and examined the factors contributing to the burden in PDD. Totally, 42 patients with PDD and 109 patients with AD and their caregivers participated in this study. The caregiver burden was measured using the Burden Interview (BI). Scores of Barthel activities of daily living (BADLs), Mini-Mental State Examination, Clinical Dementia Rating of patients, and score of Center for Epidemiologic Studies Depression scale, and Euro-quality of life of the caregivers were examined. The Unified Parkinson’s Disease Rating Scale...
Source: Journal of Geriatric Psychiatry and Neurology - January 11, 2013 Category: Genetics & Stem Cells Authors: Shin, H., Youn, J., Kim, J. S., Lee, J.-Y., Cho, J. W. Tags: Articles Source Type: research

The Role of Working Memory and Information Processing Speed on Wisconsin Card Sorting Test Performance in Parkinson Disease Without Dementia
Conclusions: Our findings address the relationship between WM and inflexible behavior exhibited by PD without dementia, argue for the importance of lower age, higher education, and level of intelligence for the successful performance on WCST; yet, the differences in cognitive performance regardless of the duration of illness within our patients with PD provide support to cognitive reserve concept. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - January 11, 2013 Category: Genetics & Stem Cells Authors: Liozidou, A., Potagas, C., Papageorgiou, S. G., Zalonis, I. Tags: Articles Source Type: research

Cognitive Impairment in Parkinson Disease: Impact on Quality of Life, Disability, and Caregiver Burden
Conclusions: The presence of dementia significantly increases caregiver burden and decreases quality of life. However, even mild levels of cognitive impairment increase disability and overall functional impairment progresses in tandem with cognitive decline. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - January 11, 2013 Category: Genetics & Stem Cells Authors: Leroi, I., McDonald, K., Pantula, H., Harbishettar, V. Tags: Articles Source Type: research

The Frontal Assessment Battery in the Differential Diagnosis of Dementia
Conclusion: Some FAB subtests might enhance diagnostic accuracy taking into account clinical history and other tests of executive function. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - January 11, 2013 Category: Genetics & Stem Cells Authors: Boban, M., Malojcic, B., Mimica, N., Vukovic, S., Zrilic, I. Tags: Articles Source Type: research

Predicting Functional Impairments in Cognitively Impaired Older Adults Using the Minnesota Cognitive Acuity Screen
Despite their growing use, few studies have examined the associations between patients’ performance on brief telephone-based cognitive assessments and their functional status. The purpose of this study was to examine the relationship between the Minnesota Cognitive Acuity Screen (MCAS), a very brief telephone-based dementia screening instrument, and functional impairment as rated by the Clinical Dementia Rating (CDR) scale in a sample of 176 individuals diagnosed with mild cognitive impairment or dementia. Results showed lower MCAS scores were correlated with poorer daily function as measured by CDR global scores and...
Source: Journal of Geriatric Psychiatry and Neurology - January 11, 2013 Category: Genetics & Stem Cells Authors: Springate, B. A., Tremont, G., Ott, B. R. Tags: Articles Source Type: research