DNA sequencing in high-throughput neuroanatomy
Publication date: Available online 4 June 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Justus M KebschullAbstractMapping brain connectivity at single cell resolution is critical for understanding brain structure. For decades, such mapping has been principally approached with microscopy techniques, aiming to visualize neurons and their connections. However, these techniques are very labor intensive and do not scale well to the complexity of mammalian brains. We recently leveraged the speed and parallelization of DNA sequencing to map the projections of thousands of single neurons in single experiments, and to map ...
Source: Journal of Chemical Neuroanatomy - June 4, 2019 Category: Neuroscience Source Type: research
The Effect of Acute Organophosphate Intoxication on Female Rat Hippocampus Cornu Ammonis Region Pyramidal Neuron Numbers, Biochemistry and Morphology
Publication date: Available online 29 May 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Orhan Bas (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - May 30, 2019 Category: Neuroscience Source Type: research
Noradrenergic terminal density varies among different groups of hypoglossal premotor neurons
Publication date: Available online 22 May 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Caroline E. Boyle, Anjum Parkar, Amanda Barror, Leszek KubinAbstractIn obstructive sleep apnea (OSA) patients, contraction of the muscles of the tongue is needed to protect the upper airway from collapse. During wakefulness, norepinephrine directly excites motoneurons that innervate the tongue and other upper airway muscles but its excitatory effects decline during sleep, thus contributing to OSA. In addition to motoneurons, NE may regulate activity in premotor pathways but little is known about these upstream effects. To start...
Source: Journal of Chemical Neuroanatomy - May 23, 2019 Category: Neuroscience Source Type: research
MicroRNAs expressed in depression and their associated pathways: a systematic review and a bioinformatics analysis
This study review systematically the literature to identify which microRNAs are currently being associated with depression and their related pathways. The electronic search was conducted in PubMed, Scopus, Scielo, ISI Web of Knowledge, and PsycINFO databases, using the search terms “Depressive Disorder” or “Depression” and “MicroRNAs”. After, microRNAs that were up and down-regulated in depression were analyzed by bioinformatics. We observed that among the 77 microRNAs cited by included studies, 54 had their levels altered in depressed individuals compared to controls, 30 being up-regulated and 24 down-regulate...
Source: Journal of Chemical Neuroanatomy - May 23, 2019 Category: Neuroscience Source Type: research
Editorial Board
Publication date: July 2019Source: Journal of Chemical Neuroanatomy, Volume 98Author(s): (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - May 21, 2019 Category: Neuroscience Source Type: research
Elevated expression of miR-302 cluster improves traumatic brain injury by inhibiting phosphorylation of connexin43 via ERK signaling
We examined apoptosis and ERK1/2 and connexin43 phosphorylation in SH-SY5Y cells undergoing pulsatile shear stress treatment. We assessed expression of miR-302 cluster members and exogenously expressed miR-302 cluster in stressed cells to determine its effect on ERK1/2 and connexin43 phosphorylation. Finally, we investigated the effects of elevated miR-302 expression on cognitive function and brain damage in TBI rats generated by the controlled cortical impact method. Pulsatile shear stress leads to increased apoptosis and upregulation of ERK1/2 and connexin43 phosphorylation in vitro. Additionally, pulsatile shear stress ...
Source: Journal of Chemical Neuroanatomy - May 15, 2019 Category: Neuroscience Source Type: research
Hitchhiking on the neuronal highway: Mechanisms of transsynaptic specificity
This article will thus touch on three topics: First, how specific are the directional transmission patterns of these viruses? Second, what are the properties that confer synaptic specificity of viral transmission? Lastly, what can we learn from this specificity, and can we use it to devise better transsynaptic tracers? (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - May 8, 2019 Category: Neuroscience Source Type: research
Heterogeneous expression patterns of fibronectin in the mouse subiculum
Publication date: Available online 1 May 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Tetsuhiko Kashima, Asako Noguchi, Yuji Ikegaya, Nobuyoshi MatsumotoAbstractThe subiculum displays as much anatomical and physiological heterogeneity as the hippocampus. Recent studies suggest that the subiculum is also diverse in terms of gene expression. However, few studies have investigated the heterogeneity of the entire subiculum. To address this issue, we focused on fibronectin because its mRNA (FN1 mRNA) is expressed in the dorsal and ventral subiculum. We immunohistochemically characterized the intracellular expression o...
Source: Journal of Chemical Neuroanatomy - May 3, 2019 Category: Neuroscience Source Type: research
Harderian gland-derived stem cells as a cytotherapy in a guinea pig model of carboplatin-induced Hearing loss
ConclusionThe isolated HG-SCs were proved to restore structure and function of cochlea in guinea pig model of hearing loss.Graphical Abstract (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - April 30, 2019 Category: Neuroscience Source Type: research
PSD95 regulates morphological development of adult-born granule neurons in the mouse hippocampus
Publication date: Available online 30 April 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Muriel D Mardones, Patricia V Jorquera, Andrea Herrera Soto, Estibaliz Ampuero, Fernando J. Bustos, Brigitte van Zundert, Lorena Varela NallarAbstractIn the adult hippocampus new neurons are generated in the dentate gyrus from neural progenitor cells. Adult-born neurons integrate into the hippocampal circuitry and contribute to hippocampal function. PSD95 is a major postsynaptic scaffold protein that is crucial for morphological maturation and synaptic development of hippocampal neurons. Here we study the function of PSD95 in...
Source: Journal of Chemical Neuroanatomy - April 30, 2019 Category: Neuroscience Source Type: research
Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms
Publication date: Available online 27 April 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Gabriela Pandini Silote, Ariandra Sartim, Amanda Sales, Amanda Eskelund, FS Guimarães, Gregers Wegener, Samia JocaAbstractSignificant limitations with the currently available antidepressant treatment strategies have inspired research on finding new and more efficient drugs to treat depression. Cannabidiol (CBD) is a non-psychotomimetic component of Cannabis sativa, and emerges in this regard as a promising compound. In 2010, we were the first laboratory to demonstrate that CBD is effective in animal models of predictive of a...
Source: Journal of Chemical Neuroanatomy - April 28, 2019 Category: Neuroscience Source Type: research
Distribution of D1 and D2 receptor- immunoreactive neurons in the paraventricular nucleus of the hypothalamus in the rat
Publication date: Available online 21 April 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Xuerui Ran, Yanli Yang, Yamei Meng, Yong Li, Li Zhou, Zhiyong Wang, Jinxia ZhuAbstractThe paraventricular nucleus (PVN) of the hypothalamus is an important center in regulating the functions of internal organs, and it is the key nucleus for coordinating endocrine, behavior and autonomic stress responses. Dopamine receptors are widely expressed in the hypothalamus and participate in the regulation of many vital activities, such as blood pressure and glycolipid metabolism, but the details of the cellular localization of dopamin...
Source: Journal of Chemical Neuroanatomy - April 22, 2019 Category: Neuroscience Source Type: research
Effect of G-CSF on the Spatial Arrangement of CA1 Hippocampal Pyramidal Neurons after Brain Ischemia in the male Rats
In conclusion, G-CSF had beneficial effects after cerebral ischemia on the neurological behavioral outcome, infarct volume and preserved the regular spatial distribution of CA1 hippocampal neurons. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - April 19, 2019 Category: Neuroscience Source Type: research
Evaluation of intracerebral ventricles volume of patients with Parkinson's disease using the atlas-based method: a methodological study
Publication date: Available online 13 April 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Hikmet Kocaman (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - April 13, 2019 Category: Neuroscience Source Type: research
Mulberrin attenuates 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced Parkinson’s disease by promoting Wnt/β-catenin signaling pathway
This study was to investigate the functions and mechanisms of mulberrin in PD. PD models were established by administering 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to Sprague Dawley rats in vivo and Lipopolysaccharide (LPS) treatment on microglial BV2 cells in vitro. Rota-rod test was applied to investigate the roles of mulberrin on MPTP-induced behavioral impairment. The effects of mulberrin on neuronal number and microglia activation were assessed by tyrosine hydroxylase (TH) immunohistochemistry and ionized calcium binding adaptor molecule-1 (Iba-1) immunofluorescence. Inflammatory cytokines and oxidative mar...
Source: Journal of Chemical Neuroanatomy - April 10, 2019 Category: Neuroscience Source Type: research
