Editorial Board
Publication date: March 2019Source: Journal of Chemical Neuroanatomy, Volume 96Author(s): (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - February 14, 2019 Category: Neuroscience Source Type: research
Aging mildly affects Dendritic Arborisation and Synaptic Protein Expression in Human Substantia Nigra Pars Compacta
Publication date: Available online 8 February 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Aditi Naskar, Anita Mahadevan, Mariamma Philip, Phalguni Anand AlladiAbstractThe protein α-synuclein, a major component of Lewy bodies in nigral neurons of aged and Parkinson's disease (PD) patients, normally co-localizes with synaptophysin and regulates the pool of synaptic vesicles. Our earlier study on substantia nigra pars compacta (SNpc) in an Asian-Indian population, demonstrated an age-associated linear but non-logarithmic increase in soluble α-synuclein without any loss of nigral neurons. Another distinctive findi...
Source: Journal of Chemical Neuroanatomy - February 8, 2019 Category: Neuroscience Source Type: research
Axonal degeneration and demyelination following traumatic spinal cord injury: A systematic review and meta-analysis
Publication date: April 2019Source: Journal of Chemical Neuroanatomy, Volume 97Author(s): Zahra Hassannejad, Mahmoud Yousefifard, Yaser Azizi, Shayan Abdollah Zadegan, Kiavash Sajadi, Mahdi Sharif-Alhoseini, Aida Shakouri-Motlagh, Mona Mokhatab, Motahareh Rezvan, Farhad Shokraneh, Mostafa Hosseini, Alexander R. Vaccaro, James S. Harrop, Vafa Rahimi-MovagharAbstractThe pathophysiology of spinal cord injury (SCI) related processes of axonal degeneration and demyelination are poorly understood. The present systematic review and meta-analysis were performed such to establish quantitative results of animal studies regarding the...
Source: Journal of Chemical Neuroanatomy - February 8, 2019 Category: Neuroscience Source Type: research
Axonal Degeneration and Demyelination Following Traumatic Spinal Cord Injury; A Systematic Review and Meta-analysis
Publication date: Available online 3 February 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Zahra Hassannejad, Mahmoud Yousefifard, Yaser Azizi, Shayan Abdollah Zadegan, Kiavash Sajadi, Mahdi Sharif-Alhoseini, Aida Shakouri-Motlagh, Mona Mokhatab, Motahareh Rezvan, Farhad Shokraneh, Mostafa Hosseini, Alexander R. Vaccaro, James S. Harrop, Vafa Rahimi-MovagharAbstractThe pathophysiology of spinal cord injury (SCI) related processes of axonal degeneration and demyelination are poorly understood. The present systematic review and meta-analysis were performed such to establish quantitative results of animal studies re...
Source: Journal of Chemical Neuroanatomy - February 4, 2019 Category: Neuroscience Source Type: research
Visual impairment in neuromyelitis optica spectrum disorders (NMOSD)
Publication date: Available online 1 February 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Yan Wu, Lianmei Zhong, Jia GengAbstractNeuromyelitis optica (NMO) and NMO spectrum disorders (NMOSD) have garnered attention due to their high pathogenicity, high risk of relapse, and poor prognosis as an inflammatory central nervous system (CNS) syndrome. There is a consensus that the anti-aquaporin-4 antibody (AQP4-IgG) is the main pathogen detectable in majority of NMOSD patients, including traditional NMO and AQP4-IgG-positive optic neuritis. In serum-negative NMOSD patients, myelin oligodendrocyte glycoprotein (MOG) an...
Source: Journal of Chemical Neuroanatomy - February 2, 2019 Category: Neuroscience Source Type: research
Intrathecal transplantation of Wharton’s jelly mesenchymal stem cells suppresses the NLRP1 inflammasome in the rat model of spinal cord injury
Publication date: April 2019Source: Journal of Chemical Neuroanatomy, Volume 97Author(s): Yousef Mohamadi, Seyed Mohammad Hossein Noori Moghahi, Mahboubeh Mousavi, Maryam Borhani-Haghighi, Farid Abolhassani, Iraj Ragerdi Kashani, Gholamreza HassanzadehAbstractAfter spinal cord injury (SCI) local inflammation is induced following secretion of interleukin-1beta (IL-1β) and IL-18. It has been described that the secretion of IL-1β and IL-18 is mediated by a cytoplasmic multiprotein complex, termed inflammasome. Mesenchymal stem cells (MSCs) have been extensively used for treating inflammatory diseases in which they showed im...
Source: Journal of Chemical Neuroanatomy - February 1, 2019 Category: Neuroscience Source Type: research
Neurons Expressing Estrogen Receptor α Differentially Innervate the Periaqueductal Gray Matter of Female Rats
Publication date: Available online 28 January 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Silvana da Silva Pacheco, Tatiane Araujo Rondini, Jackson Cioni Bittencourt, Carol Fuzeti EliasAbstractThe periaqueductal gray matter (PAG) is a brainstem site involved in distinct autonomic and behavioral responses. Among them, the motor control of female sexual behavior, including lordosis, is well described. Lordosis reflex is highly dependent on increasing levels of estradiol that occur in the afternoon of the proestrus day in normally cycling females. This effect is thought to be mediated primarily via actions in the v...
Source: Journal of Chemical Neuroanatomy - January 29, 2019 Category: Neuroscience Source Type: research
Intrathecal transplantation of Wharton's jelly mesenchymal stem cells suppresses the NLRP1 inflammasome in the rat model of spinal cord injury
Publication date: Available online 28 January 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Yousef Mohamadi, Seyed Mohammad Hossein Noori Moghahi, Mahboubeh Mousavi, Maryam Borhani-Haghighi, Farid Abolhassani, Iraj Ragerdi Kashani, Gholamreza HassanzadehAbstractAfter spinal cord injury (SCI) local inflammation is induced following secretion of interleukin-1beta (IL-1β) and IL-18. It has been described that the secretion of IL-1β and IL-18 is mediated by a cytoplasmic multiprotein complex, termed inflammasome. Mesenchymal stem cells (MSCs) have been extensively used for treating inflammatory diseases in which the...
Source: Journal of Chemical Neuroanatomy - January 29, 2019 Category: Neuroscience Source Type: research
The effects of rotenone on TH, BDNF and BDNF-related proteins in the brain and periphery: relevance to early Parkinson’s disease
Publication date: Available online 25 January 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Michaela E Johnson, Xin-Fu Zhou, Larisa BobrovskayaABSTRACTLoss of dopaminergic neurons in the substantia nigra (SN) is one of the pathological hallmarks in Parkinson’s disease (PD). This neuron loss is accompanied by reduced protein and activity levels of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis. Reduced nigral brain-derived neurotrophic factor (BDNF) has been postulated to contribute to the loss of nigral dopaminergic neurons in PD by causing a lack of trophic support. Prior to this...
Source: Journal of Chemical Neuroanatomy - January 26, 2019 Category: Neuroscience Source Type: research
Protective effects of 5-HT1A receptor antagonist and 5-HT2A receptor agonist on the biochemical and histological features in a rat model of Alzheimer’s disease
This study aimed at investigating the protective effect of NAD-299 (the selective 5-HT1A receptor antagonist) and TCB-2 (the potent5-HT2A receptor agonist) on the hippocampal oxidative stress biomarkers and the number of intact neurons in streptozotocin (STZ)-induced Alzheimer's disease in rats.Fifty adult male Wistar rats weighing 250-300 g were divided into five groups: sham, STZ-treated, STZ + NAD-299 (5 μg/1 μl icv), STZ + TCB-2 (5 μg/1 μl icv) and STZ + NAD-299 (5 μg/0.5 μl icv) +TCB-2 (5 μg/0.5 μl icv). At the end of the study, the rats were weighed, then hippocampal oxidative st...
Source: Journal of Chemical Neuroanatomy - January 24, 2019 Category: Neuroscience Source Type: research
Chemical neuroanatomy of the substantia nigra in the ovine brain
Publication date: Available online 18 January 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Samantha J. Murray, Brittney L. Black, Suzanne J. Reid, Skye R. Rudiger, C. Simon Bawden, Russell G. Snell, Henry J. Waldvogel, Richard L.M. FaullAbstractThe substantia nigra is an integral component of the basal ganglia circuitry for limbic and motor functions. Dysfunction and degeneration of the basal ganglia are fundamental aspects of neurodegenerative diseases such as Parkinson’s disease and Huntington’s disease. With the increasing use of sheep to model neurological diseases, it is crucial to understand the anatomy...
Source: Journal of Chemical Neuroanatomy - January 20, 2019 Category: Neuroscience Source Type: research
Transient receptor potential melastatin-3 in the rat sensory ganglia of the trigeminal, glossopharyngeal and vagus nerves
In this study, immunohistochemistry for TRPM3 was conducted in the rat trigeminal, glossopharyngeal and vagal sensory ganglia. TRPM3-immunoreactivity was expressed by half of sensory neurons in the trigeminal (TG), petrosal (PG) and jugular ganglia (JG), and by about 80% of sensory neurons in the nodose ganglion (NG). They mostly had small to medium-sized cell bodies. A trichrome immunofluorescence method showed co-existence of TRPM3 with TRP vanilloid 1 (TRPV1) and calcitonin gene-related peptide (CGRP). Approximately 70% of TRPM3-immunoreactive (-IR) neurons contained TRPV1-immunoreactivity in all the examined ganglia. M...
Source: Journal of Chemical Neuroanatomy - January 11, 2019 Category: Neuroscience Source Type: research
UMSC-derived exosomes promote retinal ganglion cells survival in a rat model of optic nerve crush
Publication date: Available online 10 January 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Dongyan Pan, Xin Chang, Mengqiao Xu, Mingke Zhang, Shoumei Zhang, Yue Wang, Xueting Luo, Jiajun Xu, Xiangqun Yang, Xiaodong SunAbstractTraumatic optic neuropathy or glaucoma lead to retinal ganglion cells loss and cause blindness, and there is no effective therapy strategy by far. Mesenchymal cells from the Wharton’s jelly of the umbilical cord (umbilical cord mesenchymal stem cells, UMSCs) and UMSC-derived exosomes (UMSC-Exos) are promising candidates for allogeneic therapy in regenerative medicine, but their effort on o...
Source: Journal of Chemical Neuroanatomy - January 11, 2019 Category: Neuroscience Source Type: research
Differentiation of human mesenchymal stem cells (MSC) to dopaminergic neurons: A comparison between Wharton’s Jelly and olfactory mucosa as sources of MSCs
Publication date: Available online 10 January 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Rafieh Alizadeh, Zohreh Bagher, Seyed Kamran Kamrava, Masoumeh Falah, Hatef Ghasemi Hamidabadi, Mahdi Eskandarian Boroujeni, Fatemeh Mohammadi, Sepideh Khodaverdi, Arash Zare-Sadeghi, Arta Olya, Ali KomeiliAbstractThe generation of dopaminergic neurons from stem cells is a potential therapeutic approach to treat neurodegenerative disorders, such as Parkinson’s disease. The current study aims to investigate the potential of two different types of mesenchymal stem cells derived from human Wharton’s jelly and nasal cavity ...
Source: Journal of Chemical Neuroanatomy - January 11, 2019 Category: Neuroscience Source Type: research
Editorial Board
Publication date: January 2019Source: Journal of Chemical Neuroanatomy, Volume 95Author(s): (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - January 10, 2019 Category: Neuroscience Source Type: research
