Venous thromboembolism among HIV-positive patients and anticoagulation clinic outcomes integrated within the HIV primary care setting
The purpose of this study was to explore factors associated with venous thromboembolism (VTE) among a cohort of HIV-infected patients and to describe early outcomes of warfarin anticoagulation therapy treated in a pharmacist-based anticoagulation clinic (ACC). A nested case-control study was conducted using the University of Alabama at Birmingham 1917 HIV Clinic Cohort. Conditional logistic regression was used to estimate factors associated with VTE. Among HIV-infected VTE cases, ACC-managed patients were compared to primary care provider (PCP)-managed patients to determine Time within Therapeutic INR Range (TTR). CD4 <...
Source: International Journal of STD and AIDS - October 16, 2015 Category: Global & Universal Authors: Modi, R. A., McGwin, G., Westfall, A. O., Powell, D. W., Burkholder, G. A., Raper, J. L., Willig, J. H. Tags: Original research articles Source Type: research

Alternative treatment approach to cerebral toxoplasmosis in HIV/AIDS: experience from a resource-poor setting
The current standard treatment for cerebral toxoplasmosis (pyrimethamine/sulfadiazine) often encounters problems of poor tolerability, adverse effects, frequent dropouts and non-availability of pyrimethamine/sulfadiazine in some parts of India. We have had to use the combination of two effective alternative agents for toxoplasmosis, cotrimoxazole and clindamycin, on compassionate grounds. This retrospective observational study reports superior efficacy and better tolerability of cotrimoxazole/clindamycin compared to the recommended regimen. Primary end-point (complete response) was defined as more than 50% improvement of c...
Source: International Journal of STD and AIDS - October 16, 2015 Category: Global & Universal Authors: Goswami, R. P., Goswami, R. P., Rahman, M., Ray, Y., Tripathi, S. K. Tags: Original research articles Source Type: research

What do GUM physicians think should be taught in a modern undergraduate GUM module? A qualitative inquiry
Traditional undergraduate Genitourinary Medicine (GUM) teaching in the UK concentrated on the management of individual sexually transmitted infections. There is significant variation, however, in the GUM teaching provided by different medical schools today. I undertook a qualitative interview study to gather views of GUM and other sexual health clinicians regarding what should be taught within a modern undergraduate GUM module. Nine GUM clinicians and two Sexual and Reproductive Health (SRH) clinicians participated in the study; all were directly involved in undergraduate teaching. Semi-structured interviews were conducted...
Source: International Journal of STD and AIDS - October 16, 2015 Category: Global & Universal Authors: Fernando, I. Tags: Original research articles Source Type: research

Adherence to hepatitis A virus vaccination in HIV-infected men who have sex with men
In conclusion, adherence to HAV vaccination was better than in previously published data. Because many of the factors related to vaccination completion are parameters of HIV infection, it appears that physician interest in HIV care and vaccination planning is crucial to enhancing vaccine uptake. (Source: International Journal of STD and AIDS)
Source: International Journal of STD and AIDS - October 16, 2015 Category: Global & Universal Authors: Kourkounti, S., Paparizos, V., Leuow, K., Paparizou, E., Antoniou, C. Tags: Original research articles Source Type: research

Predictors identifying those at increased risk for STDs: a theory-guided review of empirical literature and clinical guidelines
Sexually transmitted diseases (STDs) are leading causes of substantial morbidity worldwide. Identification of risk factors for estimating STD risk provides opportunities for optimising service delivery in clinical settings, including improving case finding accuracy and increasing cost-efficiency by limiting the testing of low-risk individuals. The current study was undertaken to synthesise the evidence supporting commonly cited chlamydia and gonorrhoea risk factors. The level of empirical support for the following predictors was strong/moderate: age, race/ethnicity, multiple lifetime sexual partners, sex with symptomatic p...
Source: International Journal of STD and AIDS - October 16, 2015 Category: Global & Universal Authors: Falasinnu, T., Gilbert, M., Hottes, T. S., Gustafson, P., Ogilvie, G., Shoveller, J. Tags: Review article Source Type: research

Book of Abstracts 29th European Conference on Sexually Transmitted Infections 24-26 September 2015 Hotel Melia Sitges Sitges, Catalonia (Spain): Guest Editor Dr Marti Vall-Mayans
(Source: International Journal of STD and AIDS)
Source: International Journal of STD and AIDS - September 25, 2015 Category: Global & Universal Tags: Abstracts Source Type: research

Acute prostatitis probably due to Listeria monocytogenes in an HIV-infected patient
We report a unique case of acute bacterial prostatitis probably caused by Listeria monocytogenes in an HIV-infected patient. For the best of our knowledge, this is the first case reported of a patient with this association. Our case illustrates the protean clinical presentations that L. monocytogenes infections may adopt, particularly in immunocompromised patients. (Source: International Journal of STD and AIDS)
Source: International Journal of STD and AIDS - September 22, 2015 Category: Global & Universal Authors: Roca, B., Diaz, M., Roca, M. Tags: Case reports Source Type: research

Primary HIV infection presenting as limbic encephalitis and rhabdomyolysis
Recognising the initial clinical presentation of acute HIV infection could enable earlier initiation of antiretroviral therapy and appropriate counselling to reduce the risk of transmission to others. Herein, we describe an unusual case of acute HIV infection presenting as limbic encephalitis and rhabdomyolysis. (Source: International Journal of STD and AIDS)
Source: International Journal of STD and AIDS - September 22, 2015 Category: Global & Universal Authors: Ferrada, M. A., Xie, Y., Nuermberger, E. Tags: Case reports Source Type: research

Successful antiretroviral therapy by using unusual antiretroviral combinations in heavily pre-treated patients: two case reports
We report on two HIV-1 infected patients in which the historical genotype showed mutations against all the major drug classes and in which viral suppression has been obtained by non-conventional antiretroviral therapy regimens, including the combination of darunavir at high dosage (800 mg bid), dolutegravir (50 mg bid) and a third agent, i.e. enfuvirtide in the first case and etravirine in the second one. (Source: International Journal of STD and AIDS)
Source: International Journal of STD and AIDS - September 22, 2015 Category: Global & Universal Authors: Taramasso, L., Dentone, C., Alessandrini, A., Bruzzone, B., Icardi, G., Garraffo, R., De Macina, I., Viscoli, C., Di Biagio, A., HIV/HCV Collaborative Liguria Group Tags: Case reports Source Type: research

Two-year outcome of first-line antiretroviral therapy among HIV-1 vertically-infected children in Hanoi, Vietnam
A retrospective analysis of 86 HIV-1 vertically-infected Vietnamese children with a follow-up period >24 months after initiating antiretroviral therapy (ART) was performed from 2008 to 2012, to assess the outcome of first-line ART in resource-limited settings. Of the 86 children, 68 (79.1%) were treated successfully (plasma HIV-1 viral load [VL] <1000 copies/ml), and 63 (73.3%) had full viral suppression (VL <400 copies/ml) after 24 months of ART. No significant difference between successfully treated patients and failure groups was observed in VL, CD4+ T-cell count or clinical stage at baseline; age at ART start;...
Source: International Journal of STD and AIDS - September 22, 2015 Category: Global & Universal Authors: Pham, H., Ishizaki, A., Nguyen, L., Phan, C., Phung, T., Takemoto, K., Pham, A., Bi, X., Khu, D., Ichimura, H. Tags: Original research articles Source Type: research

Reported contraceptive use, risk behaviours and STIs among military conscripts in Estonian defence forces
The objectives of this cross-sectional study were to measure factors such as condom use, contraceptive methods, and risky behaviours (i.e. drug use and sex with commercial sex workers) and investigate differences between ethnic groups, where culture could influence behaviour. Data were collected from a recruited population of 584 male, military conscripts in northeastern Europe. Using multinomial logistic regression models, statistically significant findings include an interaction between the use of contraceptive methods of Russians with casual partners and ethnicity, with higher odds of effective methods used am...
Source: International Journal of STD and AIDS - September 22, 2015 Category: Global & Universal Authors: David Parker, R., Regier, M. D., Widmeyer, J., Honaker, J., Ruutel, K. Tags: Original research articles Source Type: research

Estimation of the size of the female sex worker population in Rwanda using three different methods
This study provided a first-time estimate of the female sex worker population size in Rwanda using capture–recapture, enumeration, and multiplier methods. The capture–recapture and enumeration methods provided similar estimates of female sex worker in Rwanda. Combination of such size estimation methods is feasible and productive in low-resource settings and should be considered vital to inform national HIV programmes. (Source: International Journal of STD and AIDS)
Source: International Journal of STD and AIDS - September 22, 2015 Category: Global & Universal Authors: Mutagoma, M., Kayitesi, C., Gwiza, A., Ruton, H., Koleros, A., Gupta, N., Balisanga, H., Riedel, D. J., Nsanzimana, S. Tags: Original research articles Source Type: research

Three different patterns of CD4 recovery in a cohort of Chinese HIV patients following antiretroviral therapy - a five-year observational study
To explore the heterogeneity of CD4 responses following highly active antiretroviral therapy, the patterns of CD4 recovery of HIV-1-infected Chinese patients who have been on their first antiretroviral regimen for ≥5 years were analysed. The CD4 trajectories were traced, smoothed and differentiated into three defined profiles. Half (56.3%) were ‘satisfactory responders’, with CD4 gain of >100 cells/μL and a peak of >350 cells/μL, plateauing before the end of Year 5. Thirty-three (24.4%) were ‘continuing responders’ whose CD4 rise persisted at Year 4–5. The remaining 26 (19.3%) w...
Source: International Journal of STD and AIDS - September 22, 2015 Category: Global & Universal Authors: Naftalin, C. M., Wong, N. S., Chan, D. P., Wong, K. H., Reidpath, D. D., Lee, S. S. Tags: Original research articles Source Type: research

Glycaemic profile changes by highly active antiretroviral therapy in human immunodeficiency virus-infected patients
To study dysglycaemia in human immunodeficiency virus (HIV)-infected patients we conducted a retrospective cohort study of the glucose profile in HIV-infected patients. The fasting blood glucose was analysed taking into consideration conventional risk factors as well as HIV infection and highly active antiretroviral therapy (HAART). One hundred seventy-three cases were selected for this study. Five risk factors had significant effects (p < 0.05) on glucose levels: age, body mass index (BMI), hepatitis C virus/hepatitis B virus (HCV/HBV) co-infection, viral load (VL), and CD4+ T-lymphocyte count. Fasting blood glucose le...
Source: International Journal of STD and AIDS - September 22, 2015 Category: Global & Universal Authors: Duro, M., Rebelo, I., Barreira, S., Sarmento-Castro, R., Medeiros, R., Almeida, C. Tags: Original research articles Source Type: research

Human papillomavirus DNA and mRNA prevalence and association with cervical cytological abnormalities in the Irish HIV population
The complex interplay between HIV and human papillomavirus and its link to cervical dysplasia is poorly understood. This is the first study to assess the prevalence of oncogenic human papillomavirus mRNA in HIV-positive women, its relationship to HIV and its potential use in the triage of cervical cancer screening in HIV-positive women. In this cross-sectional study, we included 321 HIV-positive women. In all, 28.7% had abnormal cervical cytology, 51.1% were human papillomavirus DNA-positive and 21.8% tested positive for human papillomavirus mRNA. Women with a CD4 count of <200 x 106/L were more likely to test positive ...
Source: International Journal of STD and AIDS - September 22, 2015 Category: Global & Universal Authors: Loy, A., McInerney, J., Pilkington, L., Keegan, H., Delamere, S., Martin, C. M., Sheils, O., O'Leary, J. J., Mulcahy, F. Tags: Original research articles Source Type: research