Drug-induced haemolysis, renal failure, thrombocytopenia and lactic acidosis in patients with HIV and cryptococcal meningitis: a diagnostic challenge
We report two cases of patients with HIV and cryptococcal meningitis who developed severe haemolytic anaemia, thrombocytopenia, renal failure and lactic acidosis while on treatment with amphotericin B and co-trimoxazole. (Source: International Journal of STD and AIDS)
Source: International Journal of STD and AIDS - November 3, 2015 Category: Global & Universal Authors: Camara-Lemarroy, C. R., Flores-Cantu, H., Calderon-Hernandez, H. J., Diaz-Torres, M. A., Villareal-Velazquez, H. J. Tags: Case reports Source Type: research

Oral primary localized amyloidosis in HIV-infected patients: the oral face of a described skin lesion
Oral primary localized amyloidosis should be considered in the diagnosis of oral white lesions such as hyperplastic candidosis, lichen planus and lichenoid reactions; it is not associated with antiretroviral therapy use, systemic involvement or malignant transformation. (Source: International Journal of STD and AIDS)
Source: International Journal of STD and AIDS - November 3, 2015 Category: Global & Universal Authors: Anaya-Saavedra, G., Ramirez-Amador, V., Valencia-Mayoral, P. Tags: Case reports Source Type: research

Perceptions of and intentions to adopt HIV pre-exposure prophylaxis among black men who have sex with men in Los Angeles
This study assessed perceptions of pre-exposure prophylaxis (PrEP) and their association with PrEP adoption intention among a convenience sample of 224 low socioeconomic status black men who have sex with men (BMSM) residing in Los Angeles. Participants received educational information about PrEP and completed an in-person interview. More than half (60%) of the participants indicated a high intention to adopt PrEP. Younger BMSM (18–29 years) were twice as likely to report a high intention to adopt PrEP compared to older BMSM (30+ years). Only 33% of participants were aware of PrEP and no participant had ever used PrE...
Source: International Journal of STD and AIDS - November 3, 2015 Category: Global & Universal Authors: Brooks, R. A., Landovitz, R. J., Regan, R., Lee, S.-J., Allen, V. C. Tags: Original research articles Source Type: research

Bacterial loads of Ureaplasma parvum contribute to the development of inflammatory responses in the male urethra
In this study, we quantified the 16 S rRNA genes of U. parvum by a real-time polymerase chain reaction-based assay in first-voided urine from 15 symptomatic and 38 asymptomatic men who were positive only for U. parvum. We also determined the leukocyte counts by automated quantitative urine particle analysis in their first-voided urine. Positive correlations were observed between copies of the 16 S rRNA genes of U. parvum/ml and the leukocyte counts/µl in first-voided urine (p = 0.0019). The loads of ≥104 copies of the 16 S rRNA gene/ml, corresponding to ≥5 x 103 cells of U. parvum/ml, were significantly associa...
Source: International Journal of STD and AIDS - November 3, 2015 Category: Global & Universal Authors: Deguchi, T., Shimada, Y., Horie, K., Mizutani, K., Seike, K., Tsuchiya, T., Yokoi, S., Yasuda, M., Ito, S. Tags: Original research articles Source Type: research

Don't ask, sometimes tell. A survey of men who have sex with men sexual orientation disclosure in general practice
Despite advances in lesbian, gay, bisexual and transgender equality in recent years, some men who have sex with men remain at increased risk of ill-health. Positive interventions in primary care include psychological support and strategies for risk reduction. It is important that men who have sex with men can disclose sexual orientation in primary care. To quantify disclosure of sexual orientation by men who have sex with men attending general practice and identify barriers to disclosure we surveyed a group of Scottish men. A questionnaire was distributed by voluntary organisations and the National Health Service in the We...
Source: International Journal of STD and AIDS - November 3, 2015 Category: Global & Universal Authors: Metcalfe, R., Laird, G., Nandwani, R. Tags: Original research articles Source Type: research

Incident syphilis infection among people who inject drugs in Tijuana, Mexico
Given that syphilis is associated with HIV infection among people who inject drugs (PWID), we examined syphilis incidence among PWID in Tijuana, Mexico. From 2006 to 2007, 940 PWID (142 women and 798 men) were recruited via respondent-driven sampling and followed for 18 months. At semi-annual visits, participants were tested for syphilis and completed surveys, which collected information on socio-demographics, sexual behaviours, substance use and injection behaviours. Poisson regression was used to estimate syphilis incidence rates (IRs), incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Twenty-one participa...
Source: International Journal of STD and AIDS - November 3, 2015 Category: Global & Universal Authors: Pines, H. A., Rusch, M. L., Vera, A., Rangel, G., Magis-Rodriguez, C., Strathdee, S. A. Tags: Original research articles Source Type: research

Health promotion within a sex on premises venue: notes from the field
This report outlines the experiences of that on-site education/referral outreach over a five-year period. The service did afford opportunities for a minority of patrons to discuss concerns, resolve misunderstandings, obtain advice and referral, and would suggest that a health promotion presence within such a venue is a useful mechanism for engaging with highly sexually active men. (Source: International Journal of STD and AIDS)
Source: International Journal of STD and AIDS - November 3, 2015 Category: Global & Universal Authors: Debattista, J. Tags: Original research articles Source Type: research

HIV knowledge, risk perception and pre-exposure prophylaxis interest among Thai university students
To assess HIV risk perception and pre-exposure prophylaxis (PrEP) interest among university students, an anonymous survey was conducted among students from a large public university in Thailand. There were 641 participants; 118 (18%) were categorised into moderate or high-risk group. Of these 118 participants, 111 (94%) perceived themselves as no or low risk. Despite high levels of knowledge about HIV transmission risks, rates of consistent condom use with vaginal, oral and anal sex were all low (43%, 18% and 33%, respectively). The low rates of consistent condom use were significantly associated with false perception of l...
Source: International Journal of STD and AIDS - November 3, 2015 Category: Global & Universal Authors: Khawcharoenporn, T., Chunloy, K., Apisarnthanarak, A. Tags: Original research articles Source Type: research

Effectiveness of antidepressants and predictors of treatment response for depressed HIV patients in Uganda
In conclusion, antidepressants are effective in treating both moderate and more severe depression among persons living with HIV in Uganda, and education [OR (95% CI) = 4.33 (1.33–14.11)] and social support [OR (95% CI) = 1.54 (1.03–2.30)] were most predictive of treatment response. (Source: International Journal of STD and AIDS)
Source: International Journal of STD and AIDS - November 3, 2015 Category: Global & Universal Authors: Ngo, V. K., Wagner, G. J., Nakasujja, N., Dickens, A., Aunon, F., Musisi, S. Tags: Original research articles Source Type: research

A systematic review of contemporary models of shared HIV care and HIV in primary care in high-income settings
HIV shared care is uncommon in the UK although shared care could be a beneficial model of care. We review the literature on HIV shared care to determine current practice and clinical, economic and patient satisfaction outcomes. We searched MEDLINE, EMBASE, NICE Evidence, Cochrane collaboration, Google and websites of the British HIV Association, Aidsmap, Public Health England, World Health Organization and Terrence Higgins Trust using relevant search terms in August 2014. Studies published after 2000, from healthcare settings comparable to the UK that described links between primary care and specialised HIV services were i...
Source: International Journal of STD and AIDS - November 3, 2015 Category: Global & Universal Authors: Mapp, F., Hutchinson, J., Estcourt, C. Tags: Review article Source Type: research

How many MSM in Europe could benefit from PrEP - a 9 billion Euro question?
(Source: International Journal of STD and AIDS)
Source: International Journal of STD and AIDS - October 21, 2015 Category: Global & Universal Authors: Kenyon, C. R., Osbak, K. Tags: Letter to the Editor Source Type: research

Rapid progression to gummatous syphilitic hepatitis and neurosyphilis in a patient with newly-diagnosed HIV
We review the literature on hepatic involvement in patients with HIV and syphilis co-infection and describe a case of rapid progression to neurosyphilis and presumed gummatous syphilitic hepatitis in a patient newly diagnosed with HIV. To our knowledge, this is the first case of syphilitic hepatitis with gummas described in the HIV population. (Source: International Journal of STD and AIDS)
Source: International Journal of STD and AIDS - October 21, 2015 Category: Global & Universal Authors: Pilozzi-Edmonds, L., Kong, L. Y., Szabo, J., Birnbaum, L. M. Tags: Case reports Source Type: research

Seven years of undiagnosed syphilis: a missed opportunity for mother and child
We report the case of congenital syphilis diagnosed in a 7-year-old child after her 32-year-old mother was investigated for neurosyphilis. Our case illustrates the importance of antenatal syphilis screening and the need for a clear referral and management pathway for women with positive serology to ensure cases such as ours do not occur in the future. (Source: International Journal of STD and AIDS)
Source: International Journal of STD and AIDS - October 21, 2015 Category: Global & Universal Authors: Oomeer, S., Alagaratnam, J., Lyall, H., Gurtin, D., Goldmeier, D. Tags: Case reports Source Type: research

Mycobacterium haemophilum bone and joint infection in HIV/AIDS: case report and literature review
We report a case of disseminated Mycobacterium haemophilum osteomyelitis in a patient with advanced HIV infection, who later developed recurrent immune reconstitution inflammatory syndrome after commencement of antiretroviral therapy. We review previous reports of M. haemophilum bone and joint infection associated with HIV infection and describe the management of M. haemophilum-associated immune reconstitution inflammatory syndrome, including the role of surgery as an adjunctive treatment modality and the potential drug interactions between antiretroviral and antimycobacterial agents. (Source: International Journal of STD and AIDS)
Source: International Journal of STD and AIDS - October 21, 2015 Category: Global & Universal Authors: Cross, G. B., Le, Q., Webb, B., Jenkin, G. A., Korman, T. M., Francis, M., Woolley, I. Tags: Review article Source Type: research

Valaciclovir versus aciclovir for the treatment of primary genital herpes simplex: a cost analysis
The current guidelines for the treatment of primary herpes simplex in the Genito-urinary department in Sheffield Teaching Hospitals NHS Foundation Trust, recommend valaciclovir as a first-line medication. This is a prodrug of aciclovir, which has been used for many years as a treatment for primary herpes simplex virus. The basis of the recommendation largely relates to valaciclovir being more bioavailable than aciclovir. However, there is no evidence to suggest this has an effect on overall outcome with regard to symptom control and viral shedding. The purpose of the service evaluation was to discover if significant cost s...
Source: International Journal of STD and AIDS - October 21, 2015 Category: Global & Universal Authors: Pinder, M., Wright, A. Tags: Audit report Source Type: research