International Journal of Gynecological Cancer 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Symptom Experience and Self-rated Physical Functioning in Patients With Ovarian Cancer Receiving Chemotherapy: A Longitudinal Study
Conclusions
A high symptom burden was reported in this cohort of patients with ovarian cancer mainly treated with palliative intent. Low self-rated physical functioning was strongly associated with high symptom burden for the 6-month period. When chemotherapy is discussed with patients with ovarian cancer with low physical functioning, possible palliation benefits must be weighed against the added risk of long-term distressful symptoms that chemotherapy implies. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - July 1, 2018 Category: Cancer & Oncology Tags: Quality of Life Source Type: research
Malignant Ascites: Validation of a Novel Ascites Symptom Mini-Scale for Use in Patients With Ovarian Cancer
The objective of this study was to prospectively evaluate the performance of a novel Ascites Symptom Mini-Scale (ASmS) and compare it with a previously available questionnaire.
Methods
Patients with ovarian cancer–related ascites presenting for paracentesis were asked to complete the newly devised ASmS before the procedure and 1 and 24 hours after. Patients also completed a pain assessment scale and a previously validated ascites questionnaire at the same time points.
Results
The cohort included 28 patients of median age 68 years (range, 51–86 years), 13 (46.4%) with primary ovarian cancer and 15 with recurrent d...
Source: International Journal of Gynecological Cancer - July 1, 2018 Category: Cancer & Oncology Tags: Quality of Life Source Type: research
Efficacy and Safety of Oral NEPA (Netupitant/Palonosetron), the First Fixed-Combination Antiemetic, in Patients With Gynecological Cancers Receiving Platinum-Based Chemotherapy
Conclusions
Results suggest that oral NEPA is effective and safe in preventing CINV in patients with gynecological cancers treated with cisplatin- or carboplatin-based CT. Single fixed-combination NEPA is a convenient option for CINV prevention in high-risk CINV patients. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - July 1, 2018 Category: Cancer & Oncology Tags: Quality of Life Source Type: research
Influence of Prognostic Factors on Lymph Node Involvement in Endometrial Cancer: A Single-Center Experience
Discussion
Lymphovascular space invasion, histological type, and tumor stage are significant predictors of lymph node involvement in endometrial cancer. In patients at high risk of nodal involvement, lymphadenectomy should be performed systematically up to the renal vein. Large and carefully designed prospective studies are needed to evaluate patient cohorts for which a complete lymphadenectomy provides a survival benefit. In the future, the increasing use of sentinel node biopsy may facilitate a more personalized treatment of patients with endometrial cancer. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - July 1, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research
Prognostic Factors of Uterine Serous Carcinoma—A Multicenter Study
Background
The prognostic factors of uterine serous carcinoma (USC) vary among studies, and there is no report of Chinese USC patients.
Objective
The aim of this study was to investigate the clinicopathological characteristics and prognostic factors in Chinese patients with USC.
Methods
Patients with USC from 13 authoritative university hospitals in China and treated between 2004 and 2014 were retrospectively reviewed. Three-year disease-free survival rate (DFSR), cumulative recurrence, and cumulative mortality were estimated by Kaplan-Meier analyses and log-rank tests. Multivariate Cox regression analysis was used...
Source: International Journal of Gynecological Cancer - July 1, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research
Efficacy of Hyperthermic Intraperitoneal Chemotherapy and Cytoreductive Surgery in the Treatment of Recurrent Uterine Sarcoma
Conclusions
Our study is the first to compare survival outcomes of HIPEC versus conventional therapies for recurrent US and is suggestive of treatment benefit. Further studies with more patients and longer follow-up to evaluate the role of HIPEC in management of this disease are warranted. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - July 1, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research
Three-Year Recurrence-Free Survival in Patients With a Very Low Risk of Endometrial Cancer Who Did Not Undergo Lymph Node Dissection (Tree Retro): A Korean Multicenter Study
This study aimed to ascertain the survival outcomes of very low-risk endometrial cancer patients (by the Korean Gynecologic Oncology Group [KGOG] criteria) who did not undergo lymph node dissection.
Materials and Methods
Medical records of 156 consecutive patients who underwent surgical staging without lymph node dissection were collected from 10 institutions. All patients fulfilled the KGOG criteria: (1) endometrioid corpus cancer diagnosed by preoperative endometrial biopsy, (2) serum cancer antigen-125 level ≤35 IU/mL, (3) (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - July 1, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research
Surgery and Platinum/Etoposide-Based Chemotherapy for the Treatment of Epithelioid Trophoblastic Tumor
Conclusions
Surgery, including hysterectomy and resection of metastatic disease, is an important component in the treatment of women with ETT. Adjuvant chemotherapy with a platinum/etoposide-containing regimen should be used in women with metastatic disease. All 5 women with ETT in this series were cured using this approach, including the 4 who had metastatic disease. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - July 1, 2018 Category: Cancer & Oncology Tags: Gestational Trophoblastic Neoplasia Source Type: research
Prognostic Value of Serum CA19-9 and Perioperative CA-125 Levels in Ovarian Clear Cell Carcinoma
Background
There are no effective biomarkers for surveillance in ovarian clear cell carcinoma (OCCC), and the value of carbohydrate antigen 125 (CA-125) is limited. We sought to determine the value of both carbohydrate antigen 19-9 (CA19-9) and CA-125 levels postoperatively on the prognosis for OCCC.
Methods
A total of 130 patients with OCCC who were consecutively treated by cytoreduction at Fudan University Shanghai Cancer Center were reviewed retrospectively. Univariate log-rank analyses and Cox regression multivariate analyses were performed to identify predictors of recurrence-free (RFS) and overall survival (OS) ...
Source: International Journal of Gynecological Cancer - July 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research
Changing Clinical Practice: Evaluation of Implementing Recommendations for Opportunistic Salpingectomy in British Columbia and Ontario
Conclusion
This research points to the important role that local professional networks can play in encouraging clinicians to change their practice by creating a cohesive regional environment where clinicians are repeatedly exposed to important information and supported in their practice change by local thought leaders. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - July 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research
Long-Term Survival After Surgery and Radiotherapy for Recurrent or Persistent Ovarian and Tubal Cancer
This study examines the factors associated with long-term disease-specific survival (DSS) and complications after radiotherapy (RT) for recurrent or persistent ovarian and tubal cancer.
Methods/Materials
Between 1980 and 2015, 65 women with ovarian (57), tubal (3), or co-existent ovarian/endometrial carcinoma (5) received RT (>45 Gy) with curative intent for recurrent (45) or persistent cancer (20) found at second-look surgery. Surgery to debulk (± restage) was integrated into the management of all but 7 cases.
Results
Twenty-two women had no evidence of disease at last contact after a median of 15.6 years (range = ...
Source: International Journal of Gynecological Cancer - July 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research
Cyclooxygenase Inhibitors in Epithelial Ovarian Cancer Treatment
Epithelial ovarian cancer (EOC) is the fifth most common cause of cancer mortality among women. At present, EOC is treated with one or in a combination of treatments, commonly debulking surgery, combining a platinum-based and a taxane-based therapy; however, the patients have a risk of injury to the bowel, bladder, ureter, and vessels during surgery and many of them suffer from severe adverse effects caused by chemotherapy. Pharmaceutical inhibition of cyclooxygenase (COX) might be an important therapeutic tool in cancer treatment, as COX contributes to cancer progression by upregulating the levels of downstream metabolite...
Source: International Journal of Gynecological Cancer - July 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research
Economic Analysis of Neoadjuvant Chemotherapy Versus Primary Debulking Surgery for Advanced Epithelial Ovarian Cancer Using an Aggressive Surgical Paradigm
Conclusions
In the short term, NACT is cost-saving with improved outcomes. However, if PDS provides a longer-term survival advantage, it may be cost-effective. Research is needed on the role of patient preferences in tradeoffs between survival and quality of life. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - July 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research
Incidental Thoracic Findings on Routine Computed Tomography in Epithelial Ovarian Cancer
Introduction
Multidetector computed tomography (MDCT) is routinely used in the surveillance of epithelial ovarian cancer. The aim of this study was to determine the incidence of thoracic findings on routine MDCT surveillance imaging in patients with ovarian carcinoma.
Materials and Methods
Retrospective evaluation of 100 MDCT studies of patients with a diagnosis of epithelial ovarian cancer was performed at a university teaching hospital. The cross-sectional studies were reviewed by a consultant radiologist with subspeciality training in cross-sectional imaging.
Results
Intrathoracic findings were identified in 35%...
Source: International Journal of Gynecological Cancer - July 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research
The Clearance of Serum Human Epididymis Protein 4 Following Primary Cytoreductive Surgery for Ovarian Carcinoma
Conclusions
Human epididymis protein 4 derived from ovarian carcinoma had a short half-life of less than 4 hours in the circulation when cytoreductive surgery was complete. Sustained low HE4 following surgery could be a useful indicator of the completeness of cytoreduction. Plateau or rise in serum HE4 could suggest persistent disease. Comparison of values on day 1 and day 4 or 5 might have value in assessing the completeness of cytoreduction. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - July 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research
