International Journal of Gynecological Cancer This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Malignant Endometrial Polyps in Uterine Serous Carcinoma: The Prognostic Value of Polyp Size and Lymphovascular Invasion
Conclusions Polyp size does not predict extrauterine disease for USC patients with disease in polyp only or disease in polyp and endometrium. Further study is needed to investigate whether presence of LVI is a prognostic factor. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - February 21, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Added Value of Estrogen Receptor, Progesterone Receptor, and L1 Cell Adhesion Molecule Expression to Histology-Based Endometrial Carcinoma Recurrence Prediction Models: An ENITEC Collaboration Study
Conclusions Loss of ER and PR, and the presence of L1CAM are associated with high risk characteristics, and loss of PR is the strongest predictor of recurrent disease. Although a combination of these 3 markers is slightly superior to the traditional histological markers, a prognostic model including stage, PR expression, and LVSI is the most promising model in the identification of high risk carcinomas. In the stage I endometrioid carcinomas, PR immunohistochemistry appears to be of additional value in predicting recurrences. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - February 21, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Impact of Hormone Receptor Status and Ki-67 Expression on Disease-Free Survival in Patients Affected by High-risk Endometrial Cancer
Objectives The aim of this study was to evaluate the immunohistochemical (IHC) expression of Ki-67, estrogen receptors α (ERsα), and progesterone receptors (PRs) in high-risk endometrial cancer patients and to assess their prognostic impact. Methods/Materials Immunohistochemical expression of Ki-67, ERsα, and PRs was evaluated in primary untreated endometrial cancer. The correlation among IHC staining and risk factors of recurrence such as age, Federation International of Gynecology and Obstetrics stage, grading, depth of invasion, and metastatic spread was assessed. Results Eighty-two patients were available fo...
Source: International Journal of Gynecological Cancer - February 21, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Female Sex Hormone Receptor Profiling in Uterine Adenosarcomas
Conclusions Higher expression of ERα and PgR was observed in AS when compared with those with AS + SO and high-grade features. Both tumor subtypes showed similar levels of ERβ and GPER expression, although significant differences in ERβ and GPER expression were not detected. In contrast to our previous findings in uterine carcinosarcoma, ERs ERβ and GPER do not seem to play a significant role in AS in this study. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - February 21, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Characteristics and Prognosis of Stage I Ovarian Mucinous Tumors According to Expansile or Infiltrative Type
Conclusions Recurrence occurred in both types of stage I mucinous ovarian cancer. However, lethal recurrences were observed mainly in infiltrative type. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - February 21, 2018 Category: Cancer & Oncology Tags: Pathology Source Type: research

Calcification: A Disregarded or Ignored Issue in the Gynecologic Tumor Microenvironments
Although calcification in the gynecologic tumor microenvironments is a common phenomenon, doctors and researchers still disregard or ignore the issue. In fact, this change in the gynecologic tumor microenvironments is clinically significant and a number of studies have reported an association between calcification and gynecological tumor progression. In ovarian cancer, calcification is predominantly psammomatous and largely occurs in serous papillary ovarian tumors. In addition, calcification in ovarian cancer correlated with lower histologic grade and may indicate a poorer survival rate. In uterine fibroids, calcification...
Source: International Journal of Gynecological Cancer - February 21, 2018 Category: Cancer & Oncology Tags: Pathology Source Type: research

Applying Precision Medicine to Ovarian Cancer: Proof-of-Principle for a “Molecular Second Look”
Conclusions The molecular second look detects tumor-specific evidence of residual disease and provides genetic insight into tumor evolution and future recurrences beyond standard pathology. In the precision medicine era, detecting and genetically characterizing residual disease after standard treatment will be invaluable for improving patient outcomes. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - February 21, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

BRCA1 and MAD2 Are Coexpressed and Are Prognostic Indicators in Tubo-ovarian High-Grade Serous Carcinoma
Objectives The aim of this study was to investigate the relationship between BRCA1 and mitotic arrest deficiency protein 2 (MAD2) protein expression, as determined by immunohistochemistry, and clinical outcomes in epithelial ovarian carcinoma (EOC). Methods A tissue microarray consisting of 94 formalin-fixed paraffin-embedded EOC with fully matched clinicopathological data were immunohistochemically stained with anti-BRCA1 and anti-MAD2 antibodies. The cores were scored in a semiquantitative manner evaluating nuclear staining intensity and extent. Coexpression of BRCA1 and MAD2 was evaluated, and patient survival anal...
Source: International Journal of Gynecological Cancer - February 21, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Primary Ovarian Carcinoid: Extensive Clinical Experience With an Underrecognized Uncommon Entity
Conclusions Primary ovarian NET is rare and likely underrepresented in the literature. It can no longer be simply dismissed as a generally benign entity and may present with both the carcinoid syndrome and carcinoid heart disease. It requires careful evaluation and long-term review. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - February 21, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Increased STAT1 Expression in High Grade Serous Ovarian Cancer Is Associated With a Better Outcome
Conclusions These findings from a Brazilian cohort of patients with ovarian cancer reinforce the association of high STAT1 expression with better response to chemotherapy, providing additional validation of this protein as both a prognostic and predictive biomarker. Collectively, these results together with other recently published studies increase the feasibility of using the STAT1 pathway for the development of novel immunomodulator drugs that could enhance response to treatment. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - February 21, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

The FIGO Stage IVA Versus IVB of Ovarian Cancer: Prognostic Value and Predictive Value for Neoadjuvant Chemotherapy
Conclusions The reclassification of FIGO stage IV into stage IVA or IVB was not prognostic as expected. Compared with stage IVA patients, stage IVB patients have a better overall survival and may benefit more from NACT. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - February 21, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

An Outpatient, Dose-Intense, Intravenous Cisplatin and Oral Etoposide Regimen for the Treatment of Advanced, Platinum-Resistant Ovarian Cancer
Conclusions Our shorter, within-day regimen for delivering dose-intense weekly cisplatin and oral etoposide to treat platinum-resistant metastatic ovarian cancer is safe and efficacious. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - February 21, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

BRCA1, Ki67, and β-Catenin Immunoexpression Is Not Related to Differentiation, Platinum Response, or Prognosis in Women With Low- and High-Grade Serous Ovarian Carcinoma
Objective The purpose of this study was to compare the immunohistochemical expression of BRCA1, Ki67, and β-catenin in women with low-grade (LGSOC) and high-grade serous ovarian carcinomas (HGSOC) and their relationship with clinicopathological features, response to platinum-based chemotherapy, and survival. Methods For this study, 21 LGSOC and 85 HGSOC stage I to IV cases, diagnosed and treated from 1996 to 2013 and followed-up until December 2016, were included. BRCA1, Ki67, and β-catenin expression was assessed using tissue microarray-based immunohistochemistry. Results Women with HGSOC were significantly more...
Source: International Journal of Gynecological Cancer - February 21, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Mutational Aberrations Detected in Mucinous Epithelial Ovarian Cancer of Asian Women
Conclusions Our study provides further knowledge about the mutational aberrations in mEOC in Asian populations. Neither the presence of KRAS mutation nor their correlation with HER2 mutations influenced outcomes. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - February 21, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Letter to the Editor on the “European Society of Gynaecologic Oncology Quality Indicators for Advanced Ovarian Cancer Surgery” by Querleu et al, Int J Gynecol Cancer 2016;26: 1354–1363
No abstract available (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - February 21, 2018 Category: Cancer & Oncology Tags: Letter to the Editor Source Type: research