International Journal of Gynecological Cancer 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Treatment-Related Radiation Toxicity Among Cervical Cancer Patients
Conclusions
In patients with cervical cancer, radiation toxicity is correlated with lower body mass index, white race, and smoking. Despite technologic advances in radiotherapy planning and delivery, toxicity remains high and interventions to reduce the burden of treatment are needed. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - August 28, 2018 Category: Cancer & Oncology Tags: Quality of Life Source Type: research
The Effect of Body Mass Index and Weight Change on Late Gastrointestinal Toxicity in Locally Advanced Cervical Cancer Treated With Intensity-modulated Radiotherapy
Objective
To evaluate the effects of body mass index (BMI) and weight change during radiotherapy on the development of toxicity in patients with locally advanced cervical cancer (LACC) treated with intensity-modulated radiotherapy (IMRT).
Methods
A total of 245 patients were analyzed after undergoing definitive IMRT treatment between 2004 and 2015 for stage IB2 to stage IVA LACC. The patients were divided into 3 groups: underweight (BMI −5%) were associated with a higher risk of grade ≥3 or higher late gastrointestinal toxicity in patients with LACC treated with definitive IMRT. Future research on the development ...
Source: International Journal of Gynecological Cancer - August 28, 2018 Category: Cancer & Oncology Tags: Quality of Life Source Type: research
Diagnosis of Insufficiency Fracture After Radiotherapy in Patients With Cervical Cancer: Contribution of Technetium Tc 99m-Labeled Methylene Diphosphonate Single-Photon Emission Computed Tomography/Computed Tomography
Conclusions
Single-photon emission computed tomography/computed tomography should be included in the differential diagnoses when lesions show elevated technetium Tc 99m–labeled methylene diphosphonate uptake on WBS. Compared with a WBS alone, a more accurate diagnosis of IF can be obtained using SPECT/CT, which resulted not only in fewer equivocal lesions but also in a higher diagnostic accuracy. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - August 28, 2018 Category: Cancer & Oncology Tags: Quality of Life Source Type: research
Radiotherapy Improves the Survival of Patients With Metastatic Cervical Cancer: A Propensity-Matched Analysis of SEER Database
Objective
To demonstrate whether radiotherapy has an effect on the survival of patients with stage IVb (M1) cervical cancer, as it has not been adequately clarified.
Methods
We analyzed International Federation of Gynecology and Obstetrics (FIGO) stage M1 cervical cancer diagnosed in patients between 1992 and 2013 using population-based data from the Surveillance, Epidemiology, and End Results registry. Propensity score (PS) analysis with 1:1 matching and the nearest neighbor matching method was performed to ensure well-balanced characteristics of comparison groups. Data were analyzed by Kaplan-Meier and Cox proportio...
Source: International Journal of Gynecological Cancer - August 28, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research
Long-Term Oncologic Outcomes of Uterine-Preserving Surgery in Young Women With Stage Ib1 Cervical Cancer
This study aimed to evaluate oncologic outcomes of women with stage IB1 cervical cancer treated with uterine-preserving surgery (UPS) (defined as conization or trachelectomy) versus non-UPS (defined as hysterectomy of any type).
Methods
The Surveillance, Epidemiology, and End Results (SEER) database was used to identify women younger than 45 years diagnosed with stage IB1 cervical cancer from 1998 to 2012. Only those who underwent lymph node (LN) assessment were included. Outcomes of UPS versus non-UPS were analyzed.
Results
Among 2717 patients, 125 were treated with UPS and 2592 were treated with non-UPS. Those in t...
Source: International Journal of Gynecological Cancer - August 28, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research
Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Advanced Cervical Carcinoma: The Advantage of Perfusion Parameters From the Peripheral Region in Predicting the Early Response to Radiotherapy
Conclusions
Compared with perfusion parameters from the central region of tumor, perfusion parameters from the peripheral region are more valuable in predicting the early response to radiotherapy for advanced cervical carcinoma. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - August 28, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research
Response to Combination Chemotherapy With Paclitaxel/Ifosfamide/Platinum Versus Paclitaxel/Platinum for Patients With Metastatic, Recurrent, or Persistent Carcinoma of the Uterine Cervix: A Retrospective Analysis
In this study, we adjusted the dosage of the triplet regimen and introduced carboplatin in cisplatin-intolerable patients. We tested the efficacy and toxicity of the modified triplet regimen in patients with recurrent or persistent cervical cancer.
Materials and Methods
We retrospectively reviewed the medical records of patients with recurrent or persistent cervical cancer who were treated between 2003 and 2015 at Samsung Medical Center. Response rate, progression-free survival (PFS), overall survival (OS), and toxicity of paclitaxel/ifosfamide/platinum (TIP) and paclitaxel/platinum (TP) were compared.
Results
The ov...
Source: International Journal of Gynecological Cancer - August 28, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research
The Selection of Time Interval Between Surgery and Adjuvant Therapy in Early Stage Cervical Cancer
Conclusions
In cervical cancer patients, time interval between surgery and adjuvant therapy may have different effects on the prognosis in different FIGO stages. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - August 28, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research
Comparative Use of Napsin A and Glypican 3 to Distinguish Endometrial Clear Cell from Serous and Endometrioid Carcinomas
Conclusions
Napsin A is a more sensitive marker for endometrial clear cell carcinoma than glypican 3. In histologically ambiguous cases, napsin A and glypican 3 may help distinguish clear cell carcinoma from other high-grade histologies. Further investigation of endometrial clear cell carcinoma is needed to identify additional diagnostic tools for this rare histology. Correlation of a unique immunohistochemical profile and clinical outcomes is necessary. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - August 28, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research
Cancer Antigen 125 Levels are Significantly Associated With Prognostic Parameters in Uterine Papillary Serous Carcinoma
Objectives
Uterine papillary serous carcinoma (UPSC) is a highly aggressive subtype of endometrial carcinoma. Histopathologically, it resembles the pattern of serous papillary carcinoma of the ovary. Cancer antigen 125 (CA-125) is the most widely used biomarker in epithelial ovarian carcinoma. Its use in UPSC evaluation has yet to be determined. The purpose of this study was to investigate the significance of preoperative serum CA-125 as a prognostic factor in patients with UPSC.
Methods
The study cohort included all women with UPSC operated in our institution between January 2002 and June 2016. All patients underwent...
Source: International Journal of Gynecological Cancer - August 28, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research
The Importance of Lymphovascular Invasion in Uterine Adenosarcomas: Analysis of Clinical, Prognostic, and Treatment Outcomes
Objective
This retrospective study examined the clinicopathologic features of adenosarcoma patients to determine potential prognostic factors and retrospectively evaluated overall survival (OS), disease-free survival (DFS), and local recurrence-free survival (LRFS) after primary treatment of adenosarcoma including surgery, radiation, and chemotherapy.
Methods
One hundred sixty-five patients with adenosarcoma were identified from the MD Anderson Cancer Center tumor registry between 1982 and 2014. Clinical data were collected retrospectively. Pathologic characteristics were examined by sarcoma pathologists. We used the ...
Source: International Journal of Gynecological Cancer - August 28, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research
Predictive Value of Kanagawa Cancer Center Scoring System for Lymph Node Metastasis and Need for Lymphadenectomy in Patients With Endometrial Cancer: A Validation Study
The objective of this study was to determine the predictive value of Kanagawa Cancer Center (KCC) scoring system for lymph node metastasis and need for lymphadenectomy in patients with endometrial cancer.
Methods
This cross-sectional study was conducted during a 2-year period in a gynecologic oncology referral center in Southern Iran. We included a total number of 94 patients with endometrial cancer. Preoperative assessment included tumor volume, myometrium invasion, histology, and CA125. The KCC was calculated for all the patients. All the patients underwent total abdominal hysterectomy and bilateral salpingo-oophorect...
Source: International Journal of Gynecological Cancer - August 28, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research
Chemotherapy as Adjuvant Treatment for Early Stage Endometrial Cancer With High Intermediate Risk Factors
Conclusions
Chemotherapy is feasible and safe as adjuvant treatment for early-stage EC with HIR factors. Three cycles of platinum-based chemotherapy are sufficient for reducing the risk of recurrence. Further, large sample randomized studies are needed to confirm these results. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - August 28, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research
A Proposal for a Classification for Recurrent Endometrial Cancer: Analysis of a French Multicenter Database From the FRANCOGYN Study Group
Objective
Endometrial cancer (EC) recurrences are relatively common with no standardized way of describing them. We propose a new classification for them called locoregional, nodal, metastasis, carcinomatosis recurrences (rLMNC).
Patients and Methods
The data of 1230 women with EC who were initially treated by primary surgery were included in this French multicenter retrospective study. Recurrences were classified based on dissemination pathways: (1) locoregional recurrence (rL); (2) nodal recurrence (rN) for lymphatic pathway; (3) distant organ recurrence (rM) for hematogenous pathway; and (4) carcinomatosis recurren...
Source: International Journal of Gynecological Cancer - August 28, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research
Undifferentiated Endometrial Carcinomas: Clinicopathologic Characteristics and Treatment Outcomes
Conclusions
Our data are consistent with prior studies demonstrating that UEC represents a rare clinical entity characterized by high rates of locally advanced disease at presentation. However, survival outcomes appear to be comparable to other high-grade endometrial cancers. Further studies investigating optimal adjuvant therapy in these patients are warranted. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - August 28, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research
