International Journal of Gynecological Cancer This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Specific Regions, Rather than the Entire Peritoneal Carcinosis Index, are Predictive of Complete Resection and Survival in Advanced Epithelial Ovarian Cancer
Background Advanced epithelial ovarian cancer (EOC) often involves the peritoneum. Because complete resection of tumor and carcinosis is the most important prognostic factor, the peritoneal carcinosis index (PCI) has been evaluated in EOC. We hypothesize that specific PCI regions comprising the small intestine with mesentery (regions 9–12) and the hepatoduodenal ligament (region 2) are more predictive of complete resection (R = 0) and survival than the entire PCI. Materials and Methods We analyzed prospectively collected nationwide data from 507 patients with International Federation of Gynecology and Obstetrics sta...
Source: International Journal of Gynecological Cancer - January 24, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Unclassified Variants of BRCA1 and BRCA2 in Korean Patients With Ovarian Cancer
Conclusions The 2 identified likely pathogenic UVs require further verification with clinical evidence. Clarifying the clinical significance of UVs is an increasingly important step for cancer treatment in the current era of precision medicine. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - January 24, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Predicting 6- and 12-Month Risk of Mortality in Patients With Platinum-Resistant Advanced-Stage Ovarian Cancer: Prognostic Model to Guide Palliative Care Referrals
Objective Predictive models are increasingly being used in clinical practice. The aim of the study was to develop a predictive model to identify patients with platinum-resistant ovarian cancer with a prognosis of less than 6 to 12 months who may benefit from immediate referral to hospice care. Methods A retrospective chart review identified patients with platinum-resistant epithelial ovarian cancer who were treated at our institution between 2000 and 2011. A predictive model for survival was constructed based on the time from development of platinum resistance to death. Multivariate logistic regression modeling was us...
Source: International Journal of Gynecological Cancer - January 24, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Metastatic Involvement of Lesser Sac in Advanced Epithelial Ovarian Cancer
Objectives In advanced epithelial ovarian cancer (AOC), lesser sac (LS) metastasis particularly to the supragastric LS (SGLS) may be overlooked, resulting in unrecognized residual disease. We aimed to identify the frequency, distribution, and predictors of LS metastasis using laparoscopic evaluation at laparotomy and perioperative surgical complications associated with evaluation and resection/ablation. Methods Prospective observational study in consecutive patients with AOC undergoing laparotomy for primary or interval cytoreductive surgery in 2 centers between November 2013 and December 2016. Results Of 182 AOC p...
Source: International Journal of Gynecological Cancer - January 24, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Perirenal Adiposity is Associated With Lower Progression-Free Survival From Ovarian Cancer
Conclusions Our data suggest that perirenal adipose, but not body mass index, visceral, or subcutaneous fat volume that were measured within 6 months from diagnosis, is associated with lower rates of progression-free survival in ovarian cancer. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - January 24, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Clinical Predictors of Recurrence and Prognostic Value of Lymph Node Involvement in the Serous Borderline Ovarian Tumor
This study was aimed to evaluate the risk factors of recurrence and the value of nodal involvement in patients with serous borderline ovarian tumors (SBOT). Methods Two hundred twenty-five patients who underwent surgery and were diagnosed with SBOT were retrospectively studied. Univariate and multivariate analyses were used to assess the risk factors for recurrence. Patients’ clinical pathologic characteristics were compared between the patients who presented lymph node involvement and those who did not. The significant values of lymph condition influencing 5-year disease-free survival were also evaluated by statistic...
Source: International Journal of Gynecological Cancer - January 24, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Short-term Outcomes and Pregnancy Rate After Laparoscopic Fertility-Sparing Surgery for Borderline Ovarian Tumors: A Single-Institute Experience
Objective We investigated the short-term outcomes and pregnancy rate after a laparoscopic approach to fertility preservation in patients with borderline ovarian tumors (BOTs). Methods Clinic-pathologic variants of patients with BOTs who underwent conservative surgery at the Tianjin Central Hospital of Obstetrics and Gynecology between January 2009 and July 2015 were retrospectively analyzed. Results Among 211 patients with BOTs, 74 (35.1%) received conservative surgery (44 cases using a laparoscopic approach and 30 cases using a laparotomy approach). The mean age of the laparotomy group was significantly younger th...
Source: International Journal of Gynecological Cancer - January 24, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Quality of Life in Women After Pelvic Exenteration for Gynecological Malignancies: A Multicentric Study
Conclusions Long-term psycho-oncological support is strongly recommended. The reduction of ostomies seems the most effective way to improve patients’ quality of life. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - January 24, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Gene Expression Signature-Based Prediction of Lymph Node Metastasis in Patients With Endometrioid Endometrial Cancer
Conclusions Our 12-gene signature model is a useful tool for the identification of patients with endometrioid-type endometrial cancer at low risk of lymph node metastasis, particularly given that it can be used to analyze histologic tissue before surgery and used to tailor surgical options. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - January 24, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Prognostic Significance of omental Disease and the Role of Omental Sampling in Patients With Uterine Carcinosarcoma
Objectives Uterine carcinosarcomas are an aggressive and rare form of endometrial cancer. Omentectomy is not part of routine staging, but biopsy is often done because omental disease is a known poor prognostic indicator. We sought to define the role of routine omental sampling during surgical staging. Methods/Materials Patients who underwent staging for uterine carcinosarcoma at our institution from January 2000 to December 2013 were identified. Clinical and pathological data were abstracted. Univariate and multivariable Cox proportional hazard regression analysis was used to identify significant predictors of progres...
Source: International Journal of Gynecological Cancer - January 24, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

What Is the Optimal Adjuvant Treatment Sequence for Node-Positive Endometrial Cancer? Results of a National Cancer Database Analysis
Conclusions This study suggests that upfront CT followed by RT may be a better treatment sequence for adjuvant therapy in women with advanced EC. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - January 24, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Endometrial Adenocarcinomas With Significant Mucinous Differentiation: A Characterization of Intratumoral Heterogeneity of KRAS Mutations in Mucinous and Endometrioid Histologic Components
This study expands our previous report by exploring possible intratumoral heterogeneity for KRAS gene mutations in the mucinous components of mucinous carcinomas (MCs) and endometrioid carcinomas with significant mucinous differentiation (ECSMD) versus their associated “usual” endometrioid components. Materials and Methods KRAS-positive cases from our previous report were studied, including 10 MCs and 10 ECSMDs. The specimens were microscopically dissected to separately isolate morphologically mucinous and endometrioid components. Direct DNA sequencing for KRAS mutations at codons 12 and 13 using capillary electroph...
Source: International Journal of Gynecological Cancer - January 24, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

The Clinicopathological Study of 21 Cases With Uterine Smooth Muscle Tumors of Uncertain Malignant Potential: Centralized Review Can Purify the Diagnosis
Conclusions Uterine STUMPs can harbor significant uncertainty regarding the original diagnosis and clinical outcomes. Recurred cases may have an aggressive clinical course associated with multiple relapses and death. Uterine mesenchymal tumors other than ordinary myomas and overt sarcomas deserve a second opinion in centers with experience because the real diagnosis may vary significantly. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - January 24, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Comparison of the Long-Term Oncological Outcomes Between the Initial Learning Period of Robotic and the Experienced Period of Laparoscopic Radical Hysterectomy for Early-Stage Cervical Cancer
Objectives To compare the long-term oncological outcomes, complication rates, and recurrence patterns of robotic radical hysterectomy (RRH) with laparoscopic radical hysterectomy (LRH) for the treatment of early-stage cervical cancer. Methods Between January 2008 and December 2013, 65 consecutive patients underwent RRH during the learning period, and 60 consecutive patients underwent LRH during the experienced period. Results Both groups were similar with respect to clinicopathologic characteristics. The mean operative time in the RRH group was significantly longer than that in the LRH group (277.8 ± 57.3 vs 199.6...
Source: International Journal of Gynecological Cancer - January 24, 2018 Category: Cancer & Oncology Tags: Surgeons Corner Source Type: research

Efficacy of Transanal Drainage Tube Placement After Modified Posterior Pelvic Exenteration for Primary Ovarian Cancer
Conclusions Transanal drainage tube placement seems to be an effective and safe procedure that can decrease the rate of anastomotic leakage and the need for a diverting stoma after MPPE for ovarian cancer. However, some patients inevitably require a diverting stoma despite the TDT placement. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - January 24, 2018 Category: Cancer & Oncology Tags: Surgeons Corner Source Type: research