30th anniversary of the European helicobacter & microbiota study group!
(Source: Helicobacter)
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Authors: Francis M égraud Tags: EDITORIAL Source Type: research
Issue Information
(Source: Helicobacter)
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Tags: ISSUE INFORMATION Source Type: research
Review: A Japanese population ‐based meta‐analysis of vonoprazan versus PPI for Helicobacter pylori eradication therapy: Is superiority an illusion?
ConclusionsThe efficacy of VPZ is superior to PPI in first‐line H. pylori triple eradication therapies but not in second‐line therapies. The safety of VPZ ‐containing regimens appears to be equal or even superior to that of PPI. However, most reports included in this study had low levels of evidence. Hence, adequate and high‐quality RCTs will be needed to support our results. (Source: Helicobacter)
Source: Helicobacter - September 8, 2017 Category: Gastroenterology Authors: Shou Quan Dong, Tikka Prabhjot Singh, Xin Wei, Huang Yao, Hong Ling Wang Tags: REVIEW ARTICLE Source Type: research
Efficacy of three ‐in‐one capsule bismuth quadruple therapy for Helicobacter pylori eradication in clinical practice in a multinational patient population
ConclusionThree‐in‐one capsule bismuth quadruple therapy is effective and safe for treatment of H. pylori infection in routine practice, irrespective of the patient's migrational background or the number of previous treatment failures. (Source: Helicobacter)
Source: Helicobacter - August 22, 2017 Category: Gastroenterology Authors: Stephan Miehlke, Dorothea Frederking, Thomas G ünther, Erik Glocker, Bianca Eisele, Viola Andresen, Sören Schröder, Andrea Morgner Tags: ORIGINAL ARTICLE Source Type: research
Upfront immunohistochemistry improves specificity of Helicobacter pylori diagnosis. A French pathology laboratory point of view
ConclusionsAlbeit being considered as a gold standard in the detection of H. pylori, the interest of using immunohistochemistry as an upfront stain on gastric biopsies is still debated. In our opinion, its use in second line in case of ambiguous HE/HES‐Giemsa result is more appropriate. Further effort is needed to optimize the inexpensive but feasible HE/HES‐based detection of H. pylori. (Source: Helicobacter)
Source: Helicobacter - August 11, 2017 Category: Gastroenterology Authors: Florent Ginestet, Briac Guibourg, Laurent Doucet, J érémie Théreaux, Michel Robaszkiewicz, Pascale Marcorelles, Arnaud Uguen Tags: ORIGINAL ARTICLE Source Type: research
Effect on Helicobacter pylori eradication therapy against gastric cancer in Japan
ConclusionsPrescriptions for H. pylori eradication therapy increased markedly after approval of the gastritis indication by the national health insurance scheme and was associated with a significant decrease in gastric cancer deaths. (Source: Helicobacter)
Source: Helicobacter - August 3, 2017 Category: Gastroenterology Authors: Momoko Tsuda, Masahiro Asaka, Mototsugu Kato, Rumiko Matsushima, Kenji Fujimori, Kozo Akino, Shogo Kikuchi, Yingsong Lin, Naoya Sakamoto Tags: ORIGINAL ARTICLE Source Type: research
A Japanese population ‐based meta‐analysis of vonoprazan versus PPI for Helicobacter pylori eradication therapy: Is superiority an illusion?
ConclusionsThe efficacy of VPZ is superior to PPI in first‐line H. pylori triple eradication therapies but not in second‐line therapies. The safety of VPZ ‐containing regimens appears to be equal or even superior to that of PPI. However, most reports included in this study had low levels of evidence. Hence, adequate and high‐quality RCTs will be needed to support our results. (Source: Helicobacter)
Source: Helicobacter - August 1, 2017 Category: Gastroenterology Authors: Shou Quan Dong, Tikka Prabhjot Singh, Xin Wei, Huang Yao, Hong Ling Wang Tags: REVIEW ARTICLE Source Type: research
Immunologic properties and therapeutic efficacy of a multivalent epitope ‐based vaccine against four Helicobacter pylori adhesins (urease, Lpp20, HpaA, and CagL) in Mongolian gerbils
ConclusionsThis study indicated that the multivalent epitope‐based vaccine, which targeted multiple adhesins in adherence of H. pylori to the gastric mucosa, is more effective than the univalent vaccine targeting urease only. This multivalent epitope‐based vaccine may be a promising therapeutic candidate vaccine against H. pylori infection. (Source: Helicobacter)
Source: Helicobacter - August 1, 2017 Category: Gastroenterology Authors: Le Guo, Runting Yin, Guangxian Xu, Xiaojuan Gong, Zisong Chang, Dantong Hong, Hongpeng Liu, Shuqin Ding, Xuebo Han, Yuan Li, Feng Tang, Kunmei Liu Tags: ORIGINAL ARTICLE Source Type: research
Specific mutations of penicillin ‐binding protein 1A in 77 clinically acquired amoxicillin‐resistant Helicobacter pylori strains in comparison with 77 amoxicillin‐susceptible strains
ConclusionAmx resistance is associated with various substitutions in pbp1A and T593 mutation contributes to Amx resistance of H. pylori. (Source: Helicobacter)
Source: Helicobacter - August 1, 2017 Category: Gastroenterology Authors: Yong Hwan Kwon, Ji Yeon Kim, Nayoung Kim, Ji Hyun Park, Ryoung Hee Nam, Sun Min Lee, Jin ‐Wook Kim, Jung Mogg Kim, Jong Youn Park, Dong Ho Lee Tags: ORIGINAL ARTICLE Source Type: research
Protective efficacy of a hydroxy fatty acid against gastric Helicobacter infections
ConclusionsHYA prevents gastric Helicobacter infections by blocking their futalosine pathways. Daily HYA supplementation is effective for the prevention of gastric mucosa‐associated lymphoid tissue lymphoma induced by persistent infection with H. suis. (Source: Helicobacter)
Source: Helicobacter - August 1, 2017 Category: Gastroenterology Authors: Hidenori Matsui, Tetsufumi Takahashi, Somay Y. Murayama, Marina Kawaguchi, Koichi Matsuo, Masahiko Nakamura Tags: ORIGINAL ARTICLE Source Type: research
Endoscopic characteristics of infection ‐associated peptic ulcers
ConclusionThis is the first study to compare endoscopic features of peptic ulcers caused by H. pylori and O. tsutsugamushi. Peptic ulcers in patients with H. pylori infection occurred predominantly in the antrum/body/lesser curvature and presented with single, round/oval lesions, while ulcers in patients with scrub typhus occurred predominantly in the antrum/greater curvature and presented with multiple, irregular lesions. Scrub typhus should be considered as a cause of duodenal ulcer in scrub typhus‐endemic areas. (Source: Helicobacter)
Source: Helicobacter - August 1, 2017 Category: Gastroenterology Authors: Seong ‐Hyung Choi, Dong‐Min Kim, Jun Lee, Na Ra Yun Tags: ORIGINAL ARTICLE Source Type: research
Nongenetically modified Lactococcus lactis ‐adjuvanted vaccination enhanced innate immunity against Helicobacter pylori
ConclusionsThese findings suggest that GEM‐based vaccine may impact Th1/Th17 immunity to orchestrate innate immune response against H. pylori infection. (Source: Helicobacter)
Source: Helicobacter - August 1, 2017 Category: Gastroenterology Authors: Wei Liu, Zhoulin Tan, Hai Liu, Zhiqin Zeng, Shuanghui Luo, Huimin Yang, Lufeng Zheng, Tao Xi, Yingying Xing Tags: ORIGINAL ARTICLE Source Type: research
Genomic and clinical evidence uncovers the enterohepatic species Helicobacter valdiviensis as a potential human intestinal pathogen
ConclusionsHorizontal gene transfer has contributed to shape the gene repertory of H. valdiviensis, which codes for virulence factors conserved in other pathogens that are well‐known human pathogens. Additionally, the detection of H. valdiviensisDNA in diarrheic patients supports its role as a potential emergent intestinal pathogen. Further, sampling efforts are needed to uncover the clinical relevance of this species, which should be accomplished by the isolation of H. valdiviensis from ill humans and the obtention of whole genomes from clinical isolates. (Source: Helicobacter)
Source: Helicobacter - August 1, 2017 Category: Gastroenterology Authors: Pablo Fresia, Ronald Jara, Rafael Sierra, Ignacio Ferr és, Gonzalo Greif, Gregorio Iraola, Luis Collado Tags: ORIGINAL ARTICLE Source Type: research
Limited effectiveness with a 10 ‐day bismuth‐containing quadruple therapy (Pylera®) in third‐line recue treatment for Helicobacter pylori infection. A real‐life multicenter study
ConclusionIn an area of high antibiotic resistance to H. pylori, 10‐day Pylera® plus double‐dose PPI emerged as an alternative as third‐line therapy, although not achieving optimal eradication rates. TRAEs were common but were neither severe nor did they condition compliance. (Source: Helicobacter)
Source: Helicobacter - August 1, 2017 Category: Gastroenterology Authors: Enrique Rodr íguez de Santiago, Carlos Martín de Argila de Prados, Hector Miguel Marcos Prieto, Miguel Ãngel Jorge Turrión, Eva Barreiro Alonso, Alvaro Flores de Miguel, Cristobal Coba Ortiz, Carlos Rodríguez Escaja, Gustavo Pérez Álvarez, Carlos F Tags: ORIGINAL ARTICLE Source Type: research
Antibody reactivity against Helicobacter pylori proteins in a sample of the Spanish adult population in 2008 ‐2013
ConclusionsThis is the first study to describe the antibody patterns against 16 H. pylori proteins in the Spanish population. We found variability in the H. pylori antibody profiles according to both individual factors such as age and sex, and environmental factors such as the region of birth. The slightness of the reduction in seropositivity with decreasing age highlights the ongoing importance of this infection. (Source: Helicobacter)
Source: Helicobacter - July 24, 2017 Category: Gastroenterology Authors: Nerea Fern ández‐de‐Larrea, Angelika Michel, Beatriz Romero, Julia Butt, Michael Pawlita, Beatriz Pérez‐Gómez, Gemma Castaño‐Vinyals, Victor Moreno, Vicente Martín, Pilar Amiano, Jesús Castilla, Guillermo Fernández‐Tardón, Trinidad Diers Tags: ORIGINAL ARTICLE Source Type: research
