Optimization strategies aimed to increase the efficacy of H. pylori eradication therapies
ConclusionsUsing potent acid inhibition and/or higher antibiotic doses—especially by increasing the number of daily intakes—and lengthening treatments up to 14 days improves efficacy in most regimens and should be generally recommended. Triple therapies can be efficiently improved by the addition of bismuth salts, turning them into quadruple therapies. Finally, some treatments will require a combination of optimization strategies to significantly improve results. (Source: Helicobacter)
Source: Helicobacter - April 1, 2017 Category: Gastroenterology Authors: Javier P. Gisbert, Adrian G. McNicholl Tags: REVIEW ARTICLE Source Type: research
The expression of Helicobacter pylori tfs plasticity zone cluster is regulated by pH and adherence, and its composition is associated with differential gastric IL ‐8 secretion
ConclusionsA complete tfs plasticity zone cluster is a virulence factor that may be important for the colonization of H. pylori and to the development of severe outcomes of the infection with cagA‐positive strains. (Source: Helicobacter)
Source: Helicobacter - April 1, 2017 Category: Gastroenterology Authors: Bruno Silva, Alexandra Nunes, Filipa F. Vale, Raquel Rocha, Jo ão Paulo Gomes, Ricardo Dias, Mónica Oleastro Tags: ORIGINAL ARTICLE Source Type: research
Efficacy of Helicobacter pylori eradication therapies in Korea: A systematic review and network meta ‐analysis
ConclusionIn Korea, ST‐Q‐14 showed the highest efficacy in terms of eradication and a comparable tolerability, compared to the results reported for the conventional triple therapy, standard sequential therapy, hybrid therapy, and concomitant therapy. (Source: Helicobacter)
Source: Helicobacter - April 1, 2017 Category: Gastroenterology Authors: Yoon Suk Jung, Chan Hyuk Park, Jung Ho Park, Eunwoo Nam, Hang Lak Lee Tags: REVIEW ARTICLE Source Type: research
Inactivation of ferric uptake regulator (Fur) attenuates Helicobacter pylori J99 motility by disturbing the flagellar motor switch and autoinducer ‐2 production
ConclusionsThese results indicate that Fur positively modulates H. pylori J99 motility through interfering with bacterial flagellar switching. (Source: Helicobacter)
Source: Helicobacter - April 1, 2017 Category: Gastroenterology Authors: Ai ‐Yun Lee, Cheng‐Yen Kao, Yao‐Kuan Wang, Ssu‐Yuan Lin, Tze‐Ying Lai, Bor‐Shyang Sheu, Chien‐Jung Lo, Jiunn‐Jong Wu Tags: ORIGINAL ARTICLE Source Type: research
The corpus ‐predominant gastritis index can be an early and reversible marker to identify the gastric cancer risk of Helicobacter pylori‐infected nonulcer dyspepsia
ConclusionsCGI was more prevalent in H. pylori‐infected NUD subjects than in controls, was correlated with SPEM, and may serve as a marker earlier than OLGIM to indicate risk of gastric cancer. Moreover, CGI could be regressed after eradication. (Source: Helicobacter)
Source: Helicobacter - March 23, 2017 Category: Gastroenterology Authors: Hsiu ‐Chi Cheng, Yu‐Ching Tsai, Hsiao‐Bai Yang, Yi‐Chun Yeh, Wei‐Lun Chang, Hsin‐Yu Kuo, Cheng‐Chan Lu, Bor‐Shyang Sheu Tags: ORIGINAL ARTICLE Source Type: research
Eradication rate of Helicobacter Pylori infection is directly influenced by adherence to therapy in children
ConclusionAdherence to therapy is a very important factor for the outcome and has to be assessed when evaluating the outcome of an H. pylori eradication regimen in order to understand the reasons of treatment failure. As we treated only after evaluation of the resistance of the H. Pylori strains, we were expecting to reach the given objective of 90% successful treatment. Children with adherence to treatment above 90% had a successful outcome of 89,9%, whereas nonadherent had a successful outcome of 36,8%. This is the first time that adherence has been assessed accurately. (Source: Helicobacter)
Source: Helicobacter - March 17, 2017 Category: Gastroenterology Authors: Kallirroi Kotilea, Joyce Mekhael, Assaad Salame, Tania Mahler, Veronique Yvette Miendje ‐Deyi, Samy Cadranel, Patrick Bontems Tags: ORIGINAL ARTICLE Source Type: research
Helicobacter pylori infection is associated with reduced prevalence of colonic diverticular disease
ConclusionH. pylori is associated with reduced prevalence of colonic diverticular disease. The inverse association was absent after the urea breath test. Thus, we speculate that H. pylori may provide protection from colonic diverticular disease. Alternatively, H. pylori is a marker for other factors affecting disease development. (Source: Helicobacter)
Source: Helicobacter - March 16, 2017 Category: Gastroenterology Authors: Lars Erik Bartels, Peter Jepsen, Anders T øttrup, Hendrik Vilstrup, Jens Frederik Dahlerup Tags: ORIGINAL ARTICLE Source Type: research
Helicobacter Pylori infection in Omani children
(Source: Helicobacter)
Source: Helicobacter - March 12, 2017 Category: Gastroenterology Authors: Siham Al ‐Sinani, Sharef Waadallah Al‐Mulaabed, Khalid Al‐Naamani, Hyatt Al‐Sharji Tags: CORRIGENDUM Source Type: research
Issue Information
(Source: Helicobacter)
Source: Helicobacter - March 12, 2017 Category: Gastroenterology Tags: Issue Information Source Type: research
Real ‐world practice and Expectation of Asia‐Pacific physicians and patients in Helicobacter Pylori eradication (REAP‐HP Survey)
ConclusionsIt is time for physicians in Asia‐Pacific countries to adopt newer and more efficacious anti‐H. pylori regimens to meet the Kyoto consensus recommendation and their patients’ expectations. (Source: Helicobacter)
Source: Helicobacter - February 27, 2017 Category: Gastroenterology Authors: Yoen ‐Young Chuah, Deng‐Chyang Wu, Seng‐Kee Chuah, Jyh‐Chin Yang, Tzong‐Hsi Lee, Hong‐Zen Yeh, Chan‐Lin Chen, Yu‐Hwa Liu, Ping‐I Hsu Tags: ORIGINAL ARTICLE Source Type: research
Population genetic structure of Helicobacter pylori strains from Portuguese ‐speaking countries
ConclusionsH. pylori is a useful marker even for relative recent human migration events and may become rapidly differentiated from founder populations. H. pylori from Portuguese‐speaking countries assigned to hpEurope appears to be a hybrid population resulting from the admixture of AE1, AE2 and ancestral hpAfrica1. (Source: Helicobacter)
Source: Helicobacter - January 31, 2017 Category: Gastroenterology Authors: M ónica Oleastro, Raquel Rocha, Filipa F. Vale Tags: ORIGINAL ARTICLE Source Type: research
The histone ‐like protein HU has a role in gene expression during the acid adaptation response in Helicobacter pylori
ConclusionsThose results showed that H. pylori gene expression is altered by shift to low pH, thus confirming that acid exposure leads to profound changes in genomic expression, and suggest that the HU protein is a regulator that may help the bacterium adapt to the acid stress. In accordance with previous reports, we found that the HU protein participates in gene expression regulation when the microorganism is exposed to acid stress. Such transcriptional regulation underlies protein accumulation in the H. pylori cell. (Source: Helicobacter)
Source: Helicobacter - January 31, 2017 Category: Gastroenterology Authors: Alhejandra Álvarez, Héctor Toledo Tags: ORIGINAL ARTICLE Source Type: research
No evidence of a role for mitochondrial complex I in Helicobacter pylori pathogenesis
ConclusionsAlthough complex I activity is described to suppress innate immune responses and is decreased during atrophic gastritis in humans, our data suggest it does not affect H. pylori pathogenesis. (Source: Helicobacter)
Source: Helicobacter - January 31, 2017 Category: Gastroenterology Authors: Garrett Z. Ng, Bi ‐Xia Ke, Adrienne Laskowski, David R. Thorburn, Philip Sutton Tags: ORIGINAL ARTICLE Source Type: research
New bismuth ‐containing quadruple therapy in patients infected with Helicobacter pylori: A first Italian experience in clinical practice
ConclusionsPylera® achieved a remarkable eradication rate in clinical practice, irrespective if it was used as first treatment or as a rescue therapy. Treatment‐emergent adverse events were uncommon generally mild. (Source: Helicobacter)
Source: Helicobacter - January 27, 2017 Category: Gastroenterology Authors: Antonio Tursi, Francesco Di Mario, Marilisa Franceschi, Rudi De Bastiani, Walter Elisei, Gianluca Baldassarre, Antonio Ferronato, Simone Grillo, Stefano Landi, Maria Zamparella, Manuela De Polo, Laura Boscariolo, Marcello Picchio Tags: ORIGINAL ARTICLE Source Type: research
Species ‐specific immunity to Helicobacter suis
ConclusionsHelicobacter suis might evade host immune responses by skewing toward a Treg‐biased response. (Source: Helicobacter)
Source: Helicobacter - January 26, 2017 Category: Gastroenterology Authors: Iris Bosschem, Bram Flahou, Kim Van Deun, Stefaan De Koker, Jiri Volf, Annemieke Smet, Richard Ducatelle, Bert Devriendt, Freddy Haesebrouck Tags: ORIGINAL ARTICLE Source Type: research
