Keyword Index
(Source: Helicobacter)
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Tags: KEYWORD INDEX Source Type: research
Author Index
(Source: Helicobacter)
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Tags: AUTHOR INDEX Source Type: research
Abstracts
(Source: Helicobacter)
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Tags: ABSTRACTS Source Type: research
Other Helicobacters, gastric and gut microbiota
Abstract
The current article is a review of the most important and relevant literature published in 2016 and early 2017 on non‐Helicobacter pylori Helicobacter infections in humans and animals, as well as interactions between H. pylori and the microbiota of the stomach and other organs. Some putative new Helicobacter species were identified in sea otters, wild boars, dogs, and mice. Many cases of Helicobacter fennelliae and Helicobacter cinaedi infection have been reported in humans, mostly in immunocompromised patients. Mouse models have been used frequently as a model to investigate human Helicobacter infection, altho...
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Authors: Christelle P éré‐Védrenne, Bram Flahou, Mun Fai Loke, Armelle Ménard, Jamuna Vadivelu Tags: REVIEW ARTICLE Source Type: research
Treatment of Helicobacter pylori infection 2017
Abstract
This review summarizes important studies regarding Helicobacter pylori therapy published from April 2016 to April 2017. The main themes that emerge involve studies assessing the efficacy of bismuth and nonbismuth quadruple regimens. While in recent years, much of the emphasis on the use of bismuth has focussed on its utility in a second‐line setting, an increasing number of studies this year have shown excellent efficacy in first‐line therapy. The efficacy of bismuth as a second‐line after sequential and concomitant therapy was particularly noteworthy. Antibiotic resistance was more intensely studied this ye...
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Authors: Anthony O'Connor, Dominique Lamarque, Javier P. Gisbert, Colm O'Morain Tags: REVIEW ARTICLE Source Type: research
Helicobacter pylori infection in children
Abstract
Helicobacter pylori infection in children differs from that in adults, from the point of view of epidemiology, host response, clinical features, related diseases, and diagnosis, as well as treatment strategies.
The prevalence of H. pylori infection, in both children and adults, is decreasing in the Western World as well as in some developing countries, which contrasts with the increase in childhood asthma and allergic diseases. Recurrent abdominal pain is not specific during H. pylori infection in children. The role of H. pylori infection and failure to thrive, children's growth, type I diabetes mellitus (T1DM)...
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Authors: Nicolas Kalach, Patrick Bontems, Josette Raymond Tags: REVIEW ARTICLE Source Type: research
Helicobacter pylori infection and extragastric diseases in 2017
Abstract
The huge variety of extragastric diseases linked to Helicobacter pylori infection is widely known, and new studies are conducted every year on this topic. Neurological disorders and metabolic syndrome are some of the main issues debated in the most recent literature. Articles on the association of H. pylori with skin diseases, inflammatory bowel diseases, immunologic impairment, kidney dysfunction, allergic asthma, and respiratory diseases have been published as well. In this perspective, eradication therapy for this infection could become a mandatory measure in prevention strategy. (Source: Helicobacter)
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Authors: Jean ‐Dominique Korwin, Gianluca Ianiro, Giulia Gibiino, Antonio Gasbarrini Tags: REVIEW ARTICLE Source Type: research
Helicobacter pylori, gastric cancer and other gastrointestinal malignancies
Abstract
In a retrospective study performed in California, U.S.A., ca. 3% of patients with gastric intestinal metaplasia (GIM) developed gastric cancer (GC) within a median time period of 4.6 years after diagnosis of GIM. This observation stresses the importance of targeted surveillance even in regions with a low GC prevalence. Patients with alcoholic liver disease as well as survivors of colorectal and lobular breast cancer were found to be at increased risk of secondary GC. A population‐based Chinese study confirmed “serologic biopsy” as a useful screening tool for stratifying the individual risk of developing GC....
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Authors: Marino Venerito, Riccardo Vasapolli, Theodore Rokkas, Jean ‐Charles Delchier, Peter Malfertheiner Tags: REVIEW ARTICLE Source Type: research
Gastric cancer: Basic aspects
Abstract
Gastric cancer is one of the most incident and deadliest malignancies in the world. Gastric cancer is a heterogeneous disease and the end point of a long and multistep process, which results from the stepwise accumulation of numerous (epi)genetic alterations, leading to dysregulation of oncogenic and tumor suppressor pathways. Gastric cancer stem cells have emerged as fundamental players in cancer development and as contributors to gastric cancer heterogeneity. For this special issue, we will report last year's update on the gastric cancer molecular classification, and in particular address the gastric cancer grou...
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Authors: Silvia Molina ‐Castro, Joana Pereira‐Marques, Ceu Figueiredo, Jose C. Machado, Christine Varon Tags: REVIEW ARTICLE Source Type: research
Helicobacter pylori infection and nonmalignant diseases
Abstract
A substantial decrease in Helicobacter pylori‐associated peptic ulcer disease has been observed during the last decades. Drug‐related ulcers as well as idiopathic ulcers are becoming predominant and are more refractory to treatment; however, H. pylori infection still plays an important role in ulcer bleeding and recurrence after therapy. The effect of H. pylori eradication upon functional dyspepsia symptoms has been reviewed in this article and generally confirms the results of previous meta‐analyses. Additional evidence suggests a lack of impact upon the quality of life, in spite of improvement in symptoms....
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Authors: Olga Sjomina, Frederic Heluwaert, Driffa Moussata, Marcis Leja Tags: REVIEW ARTICLE Source Type: research
Helicobacter: Inflammation, immunology and vaccines
Abstract
Helicobacter pylori is usually acquired in early childhood and the infection persists lifelong without causing symptoms. In a small of cases, the infection leads to gastric or duodenal ulcer disease, or gastric cancer. Why disease occurs in these individuals remains unclear, however the host response is known to play a very important part. Understanding the mechanisms involved in maintaining control over the immune and inflammatory response is therefore extremely important. Vaccines against H. pylori have remained elusive but are desperately needed for the prevention of gastric carcinogenesis. This review focuses...
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Authors: Karen Robinson, Kazuyo Kaneko, Leif Percival Andersen Tags: REVIEW ARTICLE Source Type: research
Pathogenesis of Helicobacter pylori infection
Abstract
Helicobacter pylori is responsible for the most commonly found infection in the world's population. It is the major risk factor for gastric cancer development. Numerous studies published over the last year provide new insights into the strategies employed by H. pylori to adapt to the extreme acidic conditions of the gastric environment, to establish persistent infection and to deregulate host functions, leading to gastric pathogenesis and cancer. In this review, we report recent data on the mechanisms involved in chemotaxis, on the essential role of nickel in acid resistance and gastric colonization, on the impor...
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Authors: Vania Camilo, Toshiro Sugiyama, Eliette Touati Tags: REVIEW ARTICLE Source Type: research
Genomics of Helicobacter pylori
Abstract
As Helicobacter pylori infects half the world's population and displays an extensive intraspecies diversity, genomics is a powerful tool to understand evolution and disease, to identify factors that confer higher risk of severe sequelae, and to find new approaches for therapy both among bacterial and host targets. In line with these objectives, this review article summarizes the major findings in Helicobacter genomics in papers published between April 2016 and March 2017. (Source: Helicobacter)
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Authors: Kaisa Thorell, Philippe Lehours, Filipa F Vale Tags: REVIEW ARTICLE Source Type: research
Diagnosis of Helicobacter pylori infection
Abstract
Important progress is being made in endoscopic methods which allow clinicians to predict the presence of Helicobacter pylori based on characteristics of gastric mucosa and to obtain targeted biopsies. There are also important developments in molecular methods with various techniques derived from standard PCR, applied both on gastric biopsies and stool specimens. Progress is being made in microfluidic systems to get a reliable diagnosis in a very short time. The interest of the 13C urea breath test has been confirmed as well as stool antigen tests. Attempts are being made to find biological markers of premalignant ...
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Authors: Emilie Bess ède, Vitor Arantes, Francis Mégraud, Luiz Gonzaga Coelho Tags: REVIEW ARTICLE Source Type: research
Epidemiology of Helicobacter pylori infection
Abstract
The study of Helicobacter pylori genetic variability brought us interesting data on the history of mankind. Based on multilocus sequence typing and more recently on whole‐genome sequencing, paleomicrobiology still attracts the attention of global researchers in relation to its ancestor roots and coexistence with humans. Three studies determining the prevalence of virulence factors illustrates the controversial results obtained since 30 years by studies trying to associate prevalence of different virulence markers and clinical outcomes of H. pylori infection. Three articles analyzed the prevalence and risk of m...
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Authors: Christophe Burucoa, Anthony Axon Tags: REVIEW ARTICLE Source Type: research
