Helicobacter pylori and extragastric diseases
Abstract
During the past year, many articles were published on the extragastric diseases related to Helicobacter pylori infection. This supports the theory that some microorganisms may cause diseases even far from the primary site of infection by interfering with different biologic processes. The role of H. pylori on idiopathic thrombocytopenic purpura, sideropenica anemia, and vitamin B12 deficiency is well known. On the other hand, there is a growing interest in the bacterium's association with cardiovascular, neurologic, hematologic, dermatologic, head and neck, and uro‐gynecologic diseases, as well as diabetes melli...
Source: Helicobacter - August 15, 2016 Category: Gastroenterology Authors: Elisabetta Goni, Francesco Franceschi Tags: Review Article Source Type: research
Gastric cancer – clinical and epidemiological aspects
Abstract
Gastric cancer (GC) ranks fifth for cancer incidence and second for cancer deaths. Epidemiological data showed that survivors of Hodgkin's lymphoma and patients with pernicious anemia etiologically linked to autoimmune gastritis are at increased risk of GC. Screening of patients with autoimmune thyroid disease by means of pepsinogen (PG) I and PG I/II detected autoimmune gastritis with oxyntic gastric atrophy in one of four patients and may be recommended for GC prevention purposes. The International Agency for Research on Cancer reported a positive association between consumption of processed meet and increased G...
Source: Helicobacter - August 15, 2016 Category: Gastroenterology Authors: Marino Venerito, Alexander Link, Theodoros Rokkas, Peter Malfertheiner Tags: Original Article Source Type: research
Gastric cancer pathogenesis
Abstract
Gastric cancer (GC) results from a multistep process that is influenced by Helicobacter pylori infection, genetic susceptibility of the host, as well as of other environmental factors. GC results from the accumulation of numerous genetic and epigenetic alterations in oncogenes and tumor suppressor genes, leading to dysregulation of multiple signaling pathways, which disrupt the cell cycle and the balance between cell proliferation and cell death. For this special issue, we have selected to review last year's advances related to three main topics: the cell of origin that initiates malignant growth in GC, the mechan...
Source: Helicobacter - August 15, 2016 Category: Gastroenterology Authors: Hilmar Berger, Miguel S. Marques, Rike Zietlow, Thomas F. Meyer, Jose C. Machado, Ceu Figueiredo Tags: Original Article Source Type: research
Helicobacter pylori and non ‐malignant upper gastrointestinal diseases
Abstract
Peptic ulcer disease (PUD) has been further decreased over the last decades along with decreasing prevalence of Helicobacter pylori‐associated PUD. A delayed H. pylori eradication has been associated with an increased risk of rehospitalization for complicated recurrent peptic ulcer and reemphasized the importance of eradication especially in patients with peptic ulcer bleeding (PUB). PUB associated with NSAID/aspirin intake and H. pylori revealed an additive interaction in gastric pathophysiology which favors the “test‐and‐treat” strategy for H. pylori in patients with specific risk factors. The H. p...
Source: Helicobacter - August 15, 2016 Category: Gastroenterology Authors: Riccardo Vasapolli, Peter Malfertheiner, Arne Kandulski Tags: Original Article Source Type: research
Inflammation, immunity, and vaccines for Helicobacter pylori infection
Abstract
The tight control of the innate and adaptive immune responses in the stomach mucosa during chronic Helicobacter pylori infection is of prime importance for the bacteria to persist and for the host to prevent inflammation‐driven diseases. This review summarizes recent data on the roles of innate and adaptive immune responses during H. pylori/host interactions. In addition, the latest preclinical developments of H. pylori vaccines are discussed with a special focus on the clinical trial reported by Zeng et al., who provided evidence that oral vaccination significantly reduces the acquisition of natural H. pylo...
Source: Helicobacter - August 15, 2016 Category: Gastroenterology Authors: Dominique Velin, Kathrin Straubinger, Markus Gerhard Tags: Original Article Source Type: research
