A Japanese population ‐based meta‐analysis of vonoprazan versus PPI for Helicobacter pylori eradication therapy: Is superiority an illusion?

ConclusionsThe efficacy of VPZ is superior to PPI in first‐line H. pylori triple eradication therapies but not in second‐line therapies. The safety of VPZ ‐containing regimens appears to be equal or even superior to that of PPI. However, most reports included in this study had low levels of evidence. Hence, adequate and high‐quality RCTs will be needed to support our results.

Source: Helicobacter - August 1, 2017 Category: Gastroenterology Authors: Shou Quan Dong, Tikka Prabhjot Singh, Xin Wei, Huang Yao, Hong Ling Wang Tags: REVIEW ARTICLE Source Type: research