Hypothermia for neuroprotection in children after cardiopulmonary arrest
Abstract BackgroundCardiopulmonary arrest in paediatric patients often results in death or survival with severe brain injury. Therapeutic hypothermia, lowering of the core body temperature to 32 °C to 34 °C, may reduce injury to the brain in the period after the circulation has been restored. This therapy has been effective in neonates with hypoxic ischaemic encephalopathy and adults after witnessed ventricular fibrillation cardiopulmonary arrest. The effect of therapeutic hypothermia after cardiopulmonary arrest in paediatric patients is unknown. ObjectivesTo assess the clinical effectiveness of therapeutic hypothermia ...
Source: Evidence-Based Child Health: A Cochrane Review Journal - September 18, 2013 Category: Pediatrics Authors: Barnaby Scholefield, Heather Duncan, Paul Davies, Fang Gao Smith, Khalid Khan, Gavin D Perkins, Kevin Morris Tags: Intervention Review Source Type: research

Cochrane in context: Swimming training for asthma in children and adolescents aged 18 years and under
Abstract Cochrane Review: Swimming training for asthma in children and adolescents aged 18 years and under Beggs S, Foong YC, Le HCT, Noor D, Wood‐Baker R, Walters JAE. Swimming training for asthma in children and adolescents aged 18 years and under. Cochrane Database of Systematic Reviews 2013, Issue 4. Art. No.: CD009607. DOI: 10.1002/14651858.CD009607.pub2 This companion piece to the review, “Swimming training for asthma in children and adolescents aged 18 years and under,” contains the following pieces: The abstract of the review A commentary from one or more of the review authors, explaining why the review t...
Source: Evidence-Based Child Health: A Cochrane Review Journal - September 18, 2013 Category: Pediatrics Authors: Sean Beggs, Julia A. E. Walters Tags: Commentary Source Type: research

Swimming training for asthma in children and adolescents aged 18 years and under
Abstract BackgroundAsthma is the most common chronic medical condition in children and a common reason for hospitalisation. Observational studies have suggested that swimming, in particular, is an ideal form of physical activity to improve fitness and decrease the burden of disease in asthma. ObjectivesTo determine the effectiveness and safety of swimming training as an intervention for asthma in children and adolescents aged 18 years and under. Search methodsWe searched the Cochrane Airways Group's Specialised Register of trials (CENTRAL), MEDLINE , EMBASE, CINAHL, in November 2011, and repeated the search of CENTRAL in J...
Source: Evidence-Based Child Health: A Cochrane Review Journal - September 18, 2013 Category: Pediatrics Authors: Sean Beggs, Yi Chao Foong, Hong Cecilia T Le, Danial Noor, Richard Wood‐Baker, Julia AE Walters Tags: Intervention Review Source Type: research

Antibiotics for the common cold—do they work?
Abstract Eco‐paediatrics is an occasional feature in Evidence‐Based Child Health: A Cochrane Review Journal. Our goal is to contribute to the worldwide discussion on reducing waste in health care. In each instalment, we will select a recent Cochrane review highlighting a practice, still in use, which the available evidence tells us should be discontinued. (Source: Evidence-Based Child Health: A Cochrane Review Journal)
Source: Evidence-Based Child Health: A Cochrane Review Journal - September 18, 2013 Category: Pediatrics Authors: Joan Robinson Tags: Eco‐Paediatrics Source Type: research

New directions for EBCH
(Source: Evidence-Based Child Health: A Cochrane Review Journal)
Source: Evidence-Based Child Health: A Cochrane Review Journal - September 18, 2013 Category: Pediatrics Authors: Denise Thomson Tags: Editorial Source Type: research

Issue Information
(Source: Evidence-Based Child Health: A Cochrane Review Journal)
Source: Evidence-Based Child Health: A Cochrane Review Journal - September 1, 2013 Category: Pediatrics Tags: Issue Information Source Type: research

Commentary on ‘Propofol versus thiopental sodium for the treatment of refractory status epilepticus—Still no answer’
Abstract This is a commentary on a Cochrane review, published in this issue of EBCH, first published as: Prabhakar H, Bindra A, Singh GP, Kalaivani M. Propofol versus thiopental sodium for the treatment of refractory status epilepticus. Cochrane Database of Systematic Reviews 2012, Issue 8. Art. No.: CD009202. DOI: 10.1002/14651858.CD009202.pub2. (Source: Evidence-Based Child Health: A Cochrane Review Journal)
Source: Evidence-Based Child Health: A Cochrane Review Journal - July 12, 2013 Category: Pediatrics Authors: Jeffrey Buchhalter, Antonia Stang Tags: Commentary Source Type: research

Propofol versus thiopental sodium for the treatment of refractory status epilepticus (Review)
This study was a small, single‐blind, multicentre trial studying adults with RSE and receiving either propofol or thiopental sodium for the control of seizure activity (Rossetti 2011). This study showed a wide confidence interval suggesting that the drugs may differ in efficacy up to more than two‐fold. There was no evidence of a difference between the drugs with respect to the outcome measures such as control of seizure activity and functional outcome at three months. Authors' conclusionsThere is lack of robust and randomised controlled evidence that can clarify the efficacy of propofol and thiopental sodium over eac...
Source: Evidence-Based Child Health: A Cochrane Review Journal - July 12, 2013 Category: Pediatrics Authors: Hemanshu Prabhakar, Ashish Bindra, Gyaninder Pal Singh, Mani Kalaivani Tags: Intervention Review Source Type: research

Commentary on ‘Prophylactic drug management for febrile seizures in children’
Abstract This is a commentary on a Cochrane review, published in this issue of EBCH, first published as: Offringa M, Newton R. Prophylactic drug management for febrile seizures in children. Cochrane Database of Systematic Reviews 2012, Issue 4. Art. No.: CD003031. DOI: 10.1002/14651858.CD003031.pub2. (Source: Evidence-Based Child Health: A Cochrane Review Journal)
Source: Evidence-Based Child Health: A Cochrane Review Journal - July 12, 2013 Category: Pediatrics Authors: Jeanette Robertson Tags: Commentary Source Type: research

Prophylactic drug management for febrile seizures in children (Review)
Abstract BackgroundFebrile seizures occurring in a child older than one month during an episode of fever affect 2% to 4% of children in Great Britain and the United States and recur in 30%. Rapid‐acting antiepileptics and antipyretics given during subsequent fever episodes have been used to avoid the adverse effects of continuous antiepileptic drugs. ObjectivesTo evaluate the effectiveness and safety of antiepileptic and antipyretic drugs used prophylactically to treat children with febrile seizures. Search methodsWe searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011. Issue 3...
Source: Evidence-Based Child Health: A Cochrane Review Journal - July 12, 2013 Category: Pediatrics Authors: Martin Offringa, Richard Newton Tags: Intervention Review Source Type: research

Commentaries on ‘Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections’ with a response from the review authors
Abstract These are commentaries on a Cochrane review, published in this issue of EBCH, first published as: Schuetz P, Müller B, Christ‐Crain M, Stolz D, Tamm M, Bouadma L, Luyt CE, Wolff M, Chastre J, Tubach F, Kristoffersen KB, Burkhardt O, Welte T, Schroeder S, Nobre V, Wei L, Bhatnagar N, Bucher HC, Briel M. Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Database of Systematic Reviews 2012, Issue 9. Art. No.: CD007498. DOI: 10.1002/14651858.CD007498.pub2. (Source: Evidence-Based Child Health: A Cochrane Review Journal)
Source: Evidence-Based Child Health: A Cochrane Review Journal - July 12, 2013 Category: Pediatrics Authors: Vikram Sabhaney, Paul Enarson, Adam D. Irwin, Enitan D. Carrol, Philipp Schuetz, Matthias Briel, Heiner C. Bucher, Beat Mueller, Tags: Commentary Source Type: research

Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections
Abstract BackgroundAcute respiratory infections (ARIs) comprise a large and heterogeneous group of infections including bacterial, viral and other aetiologies. In recent years, procalcitonin ‐ the prohormone of calcitonin ‐ has emerged as a promising marker for the diagnosis of bacterial infections and for improving decisions about antibiotic therapy. Several randomised controlled trials (RCTs) have demonstrated the feasibility of using procalcitonin for starting and stopping antibiotics in different patient populations with acute respiratory infections and different settings ranging from primary care to emergency depa...
Source: Evidence-Based Child Health: A Cochrane Review Journal - July 12, 2013 Category: Pediatrics Authors: Philipp Schuetz, Beat Muller, Mirjam Christ‐Crain, Daiana Stolz, Michael Tamm, Lila Bouadma, Charles E Luyt, Michel Wolff, Jean Chastre, Florence Tubach, Kristina B Kristoffersen, Olaf Burkhardt, Tobias Welte, Stefan Schroeder, Vandack Nobre, Long Wei, Tags: Intervention Review Source Type: research

Commentary on ‘Glucocorticoids for the treatment of anaphylaxis’
Abstract This is a commentary on a Cochrane review, published in the issue of EBCH, first published as: Choo KJL, Simons FER, Sheikh A. Glucocorticoids for the treatment of anaphylaxis. Cochrane Database of Systematic Reviews 2012, Issue 4. Art. No.: CD007596. DOI: 10.1002/14651858.CD007596.pub3. (Source: Evidence-Based Child Health: A Cochrane Review Journal)
Source: Evidence-Based Child Health: A Cochrane Review Journal - July 12, 2013 Category: Pediatrics Authors: Alexandra F. Santos, Gideon Lack Tags: Commentary Source Type: research

Glucocorticoids for the treatment of anaphylaxis
Abstract BackgroundAnaphylaxis is a serious hypersensitivity reaction that is rapid in onset and may result in death. Anaphylaxis guidelines recommend glucocorticoids for the treatment of people experiencing anaphylaxis.  ObjectivesWe sought to assess the benefits and harms of glucocorticoid treatment during episodes of anaphylaxis. Search methodsIn our previous version we searched the literature until September 2009. In this version we searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 3), MEDLINE (Ovid) (1956 to September 2011), EMBASE (Ovid) (1982 to September 2011),...
Source: Evidence-Based Child Health: A Cochrane Review Journal - July 12, 2013 Category: Pediatrics Authors: Karen Jui Lin Choo, F Estelle R Simons, Aziz Sheikh Tags: Intervention Review Source Type: research

Commentary on ‘Interventions for promoting re‐integration and reducing harmful behaviour and lifestyles in street‐connected children and young people’ with a response from the review authors
Abstract This is a commentary on a Cochrane review, published in the issue of EBCH, first published as: Coren E, Hossain R, Pardo Pardo J, Veras MMS, Chakraborty K, Harris H, Martin AJ. Interventions for promoting re‐integration and reducing harmful behaviour and lifestyles in street‐connected children and young people. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD009823. DOI: 10.1002/14651858.CD009823.pub2. (Source: Evidence-Based Child Health: A Cochrane Review Journal)
Source: Evidence-Based Child Health: A Cochrane Review Journal - July 12, 2013 Category: Pediatrics Authors: Rahila U. Christian, Esther Coren, Rosa Hossain Tags: Commentary Source Type: research