Propofol versus thiopental sodium for the treatment of refractory status epilepticus (Review)

This study was a small, single‐blind, multicentre trial studying adults with RSE and receiving either propofol or thiopental sodium for the control of seizure activity (Rossetti 2011). This study showed a wide confidence interval suggesting that the drugs may differ in efficacy up to more than two‐fold. There was no evidence of a difference between the drugs with respect to the outcome measures such as control of seizure activity and functional outcome at three months. Authors' conclusionsThere is lack of robust and randomised controlled evidence that can clarify the efficacy of propofol and thiopental sodium over each other in the treatment of RSE. There is a need for large, randomised controlled trials for this serious condition. Plain Language SummaryPropofol versus thiopental sodium for the treatment of refractory status epilepticusPersistent convulsions are a major medical emergency associated with significant morbidity and mortality. At times, these convulsions fail to respond to first‐ and second‐line drug therapy and may be observed in up to 31% of patients suffering from persistent seizure or convulsive activities. Persistent seizure activity may become refractory to antiepileptic drugs. Anaesthetics such as thiopental sodium and propofol are frequently given for control of seizures in such situations. Both agents have inherent side effects and complications. This review appraises the evidence for the these anaesthetic drugs in controlling seizure activity i...
Source: Evidence-Based Child Health: A Cochrane Review Journal - Category: Pediatrics Authors: Tags: Intervention Review Source Type: research