Brain morphology in school-aged children with prenatal opioid exposure: A structural MRI study
Both animal and human studies have suggested that prenatal opioid exposure may be detrimental to the developing fetal brain. However, results are somewhat conflicting. Structural brain changes in children with prenatal opioid exposure have been reported in a few studies, and such changes may contribute to neuropsychological impairments observed in exposed children. (Source: Early Human Development)
Source: Early Human Development - February 6, 2017 Category: Perinatology & Neonatology Authors: Eivind Sirnes, Leif Oltedal, Hauke Bartsch, Geir Egil Eide, Irene B. Elgen, Stein Magnus Aukland Source Type: research
Unconjugated free bilirubin in preterm infants
Hyperbilirubinemia guidelines are based on total serum bilirubin (TSB), in combination with either gestational age (GA) or birth weight (BW), postnatal age and specific risk factors. However, TSB is a poor predictor of bilirubin-induced neurotoxicity (BIND). Free unconjugated bilirubin (UCBfree) and the UCBfree/TSB ratio are more directly related to BIND, but data on their postnatal courses are unknown. (Source: Early Human Development)
Source: Early Human Development - February 5, 2017 Category: Perinatology & Neonatology Authors: Lori W.E. van der Schoor, Peter H. Dijk, Henkjan J. Verkade, Anna C.J. Kamsma, Andrea B. Schreuder, Henk Groen, Christian V. Hulzebos Source Type: research
Social impairments among children perinatally exposed to oxytocin or oxytocin receptor antagonist
Oxytocin (OT) is involved in modulating the social brain, suggesting that it may have a role in the etiology and treatment of Autism Spectrum Disorders (ASD) [1 –4]. Clinical characteristics of ASD include impairments in social cognition and corresponding deficits in social behavior that are mediated in part by OT neural pathways [5]. Notably, there is some evidence that OT can cross the placenta and enter fetal circulation [6], and that OT and OT antagon ist (OTA) can penetrate the blood-brain barrier in small amounts [7,8]. (Source: Early Human Development)
Source: Early Human Development - February 5, 2017 Category: Perinatology & Neonatology Authors: Edwa Friedlander, Ohad Feldstein, David Mankuta, Maya Yaari, Ayelet Harel-Gadassi, Richard P. Ebstein, Nurit Yirmiya Source Type: research
Short-term weight gain velocity in infants with congenital diaphragmatic hernia (CDH)
Appropriate post-natal growth remains a mainstay of therapeutic goals for infants with CDH, with the hypothesis that optimizing linear growth will improve survival through functional improvements in pulmonary hypoplasia. However, descriptions of growth and the effect on survival are limited in affected infants. (Source: Early Human Development)
Source: Early Human Development - February 4, 2017 Category: Perinatology & Neonatology Authors: Jason Gien, Karna Murthy, Eugenia K Pallotto, Beverly Brozanski, Louis Chicoine, Isabella Zaniletti, Ruth Seabrook, Sarah Keene, Deepthi Alapati, Nicolas Porta, Natalie Rintoul, Theresa R. Grover, Children's Hospitals Neonatal Consortium CDH Study Group Source Type: research
Bedside ROP screening and telemedicine interpretation integrated to a neonatal transport system: Economic aspects and return on investment analysis
Peter Cerny Ambulance Service – Premature Eye Rescue Program (PCA-PERP) uses digital retinal imaging (DRI) with remote interpretation in bedside ROP screening, which has advantages over binocular indirect ophthalmoscopy (BIO) in screening of premature newborns. We aimed to demonstrate that PCA-PERP provides good value for the money and to model the cost ramifications of a similar newly launched system. (Source: Early Human Development)
Source: Early Human Development - February 3, 2017 Category: Perinatology & Neonatology Authors: G ábor Kovács, Zsolt Somogyvári, Erika Maka, László Nagyjánosi Source Type: research
Biomarkers for the diagnosis of neonatal sepsis and necrotizing entercolitis: Clinical practice guidelines
Sepsis and necrotizing enterocolitis are major contributors to morbidity and mortality in neonates, especially in those born preterm. While therapeutic interventions are available for both (for e.g. antibiotics), a major dilemma is early diagnosis so that these interventions can be done in a timely manner. As clinical evaluation alone is unreliable in identifying infants in the early stages of neonatal sepsis or necrotizing enterocolitis, there is a need to find specific biomarkers associated with these conditions to improve diagnostic capabilities. (Source: Early Human Development)
Source: Early Human Development - January 24, 2017 Category: Perinatology & Neonatology Authors: Margaret Gilfillan, Vineet Bhandari Source Type: research
MRI Patterns of brain injury and neurodevelopmental outcomes in neonates with severe anaemia at birth
Severe neonatal anaemia at birth was associated with a white matter predominant pattern of injury, the severity of which was related to neurodevelopmental outcomes. Early MRI and long-term follow-up are advisable following severe neonatal anaemia. (Source: Early Human Development)
Source: Early Human Development - January 16, 2017 Category: Perinatology & Neonatology Authors: Bego ña Loureiro, Miriam Martinez-Biarge, Francesca Foti, Maria Papadaki, Frances M Cowan, Courtney J Wusthoff Source Type: research
Concordance between maternal recall of birth complications and data from obstetrical records
Prenatal complications are associated with poor outcomes in the offspring. Access to medical records is limited in the United States and investigators often rely on maternal report of prenatal complications. (Source: Early Human Development)
Source: Early Human Development - January 14, 2017 Category: Perinatology & Neonatology Authors: Kate Keenan, Alison Hipwell, Rose McAloon, Amy Hoffmann, Arpita Mohanty, Kelsey Magee Source Type: research
Evaluation of motor and cognitive development among infants exposed to HIV
This study of a prospective and cross-sectional nature compared the motor and cognitive development of HIV-exposed and unexposed infants in their first 18months of age. 40 infants exposed to HIV and antiretroviral therapy (Experimental Group - EG) and 40 unexposed infants (Control Group - CG) participated in the study. They were divided into four age groups of 4, 8, 12 and 18months old, with 10 infants from EG and 10 from CG in each group. The infants were evaluated once on motor and cognitive development by the Bayley Scale of Infant and Toddler Development. (Source: Early Human Development)
Source: Early Human Development - January 13, 2017 Category: Perinatology & Neonatology Authors: Kaitiana Martins da Silva, Cristina dos Santos Cardoso de S á, Raquel Carvalho Source Type: research
Corrigendum to “Parenting very preterm infants and stress in Neonatal Intensive Care Units” [Early Hum. Dev. 101 (2016) 3–9]
The authors regret to inform that they detect an error on Table 5 of the manuscript. We kindly ask you to correct the values regarding the association between the father's educational level and the subscale sights and sounds: the values [ −0.408 (−0.183 to 0.359)] should be replaced by [−0.025 (−0.408 to 0.359)]. This change has no implications for the results interpretation or the discussion of the paper, however we notice the error and if possible, we would like to correct it. (Source: Early Human Development)
Source: Early Human Development - January 13, 2017 Category: Perinatology & Neonatology Authors: In ês Baía, Mariana Amorim, Susana Silva, Michelle Kelly-Irving, Cláudia de Freitas, Elisabete Alves Tags: Corrigendum Source Type: research
A retrospective audit of bacterial culture results of donated human milk in Perth, Western Australia
The bacterial content of donated human milk is either endogenous or introduced via contamination. Defining milk bank bacterial content will allow researchers to devise appropriate tests for significant and commonly encountered organisms. (Source: Early Human Development)
Source: Early Human Development - January 11, 2017 Category: Perinatology & Neonatology Authors: Yahya Almutawif, Benjamin Hartmann, Megan Lloyd, Wendy Erber, Donna Geddes Source Type: research
Neonatal acute kidney injury – Severity and recovery prediction and the role of serum and urinary biomarkers
Neonatal acute kidney injury is common, in part due to incomplete renal maturation and also due to frequent exposure to risk factors for acute kidney injury such as perinatal asphyxia, extracorporeal-membrane-oxygenation, cardiac surgery, sepsis, prematurity and nephrotoxicity. However the current method by which acute kidney injury is diagnosed is sub-optimal and not universally accepted which impairs the accurate estimation of the true incidence of neonatal acute kidney injury. Serum Cystatin-C, urinary NGAL, KIM-1 and IL-18 are promising neonatal acute kidney injury biomarkers however the diagnosis of acute kidney injur...
Source: Early Human Development - January 11, 2017 Category: Perinatology & Neonatology Authors: Deirdre U. Sweetman Source Type: research
Reference values for nucleated red blood cells and serum lactate in very and extremely low birth weight infants in the first week of life
To provide reference values for nucleated red blood cells and serum lactate concentrations in very and extremely low birth weight (VLBW/ELBW) infants in the first week of life. (Source: Early Human Development)
Source: Early Human Development - January 2, 2017 Category: Perinatology & Neonatology Authors: Martin Poryo, Antonia Wissing, Aylin Ayg ün, Jürgen Geisel, Stefan Wagenpfeil, Michael Zemlin, Sascha Meyer Source Type: research
Response to d-transposition of the great arteries and ductal dependent pulmonary circulation
With great interest, we have read the letter to the authors by Dr. Ghimire regarding our recent article describing the course of cerebral oxygen saturation (rcSO2) and extraction (FTOE) in infants diagnosed prenatally with several types of duct-dependent congenital heart disease (CHD) [1]. (Source: Early Human Development)
Source: Early Human Development - January 2, 2017 Category: Perinatology & Neonatology Authors: Mirthe J Mebius, Michelle E van der Laan, Elise A Verhagen, Arend F Bos, Elisabeth MW Kooi Source Type: research
Left ventricular rotational mechanics in early infancy: Normal reference ranges and reproducibility of peak values and time to peak values
Left ventricular cardiac twist and torsion values have been described in premature and term neonates, but not in early infancy. Early and late peak untwist rates and time to peak (TTP) values have not been described in infants. (Source: Early Human Development)
Source: Early Human Development - December 30, 2016 Category: Perinatology & Neonatology Authors: Shiraz A Maskatia, Wesley Lee, Carolyn A Altman, Nancy A Ayres, Douglas K Feagin, Ricardo H Pignatelli Source Type: research
