The effect of the small amount of formaldehyde in the SurePath liquid when establishing protocols for immunocytochemistry
Conclusions: The small amount of formaldehyde in the SurePath liquid seems to affect the immunoreactivity. Local immunocytochemistry protocols in the cytology laboratories should consider this when optimizing their procedures. Postfixation with formalin should be omitted. (Source: CytoJournal)
Source: CytoJournal - November 15, 2016 Category: Pathology Authors: Ellen Cathrine Bjonness-Jacobsen Anne Kristine Kallevag Eriksen Vidar Nylokken Hagen Kirsten Margrethe Ostbye Anna Witterso Mette Kristin Pedersen Torill Sauer Source Type: research
Oncocytic variant of poorly differentiated thyroid carcinoma: " Is diagnosis possible by fine-needle aspiration ? "
Mine Onenerk, Sule Canberk, Pembegul Gunes, Murat Erkan, Gamze Z KilicogluCytoJournal 2016 13(1):23-23Poorly differentiated thyroid carcinoma (PDTC) is a very rare entity, and the diagnosis can be made on histopathology specimens. However, recognition of characteristic features of PDTC is significant on fine-needle aspirations (FNAs) to differentiate this entity from well-differentiated and anaplastic thyroid carcinomas. Here, we present an FNA case concordant with "oncocytic variant of PDTC" and discuss whether definitive diagnosis can be given on FNAs to assess the prognosis in clinically inoperable patients. (Source: CytoJournal)
Source: CytoJournal - October 12, 2016 Category: Pathology Authors: Mine Onenerk Sule Canberk Pembegul Gunes Murat Erkan Gamze Z Kilicoglu Source Type: research
Endoscopic ultrasound-guided fine needle aspiration cytology of metastatic renal cell carcinoma to the pancreas: A multi-center experience
Conclusions: EUS-FNA cytology is useful for the diagnosis of metastatic RCC to the pancreas. Cytomorphology can be aided with patient history, imaging analyses, cell blocks, and immunochemical stains. (Source: CytoJournal)
Source: CytoJournal - October 12, 2016 Category: Pathology Authors: Rahul Pannala Karyn M Hallberg-Wallace Amber L Smith Aziza Nassar Jun Zhang Matthew Zarka Jordan P Reynolds Longwen Chen Source Type: research
Erratum: CytoJournal Quiz Cases: Publishing open access, PubMed searchable cytopathology cases with educational messages.
CytoJournal 2016 13(1):25-25 (Source: CytoJournal)
Source: CytoJournal - October 12, 2016 Category: Pathology Source Type: research
A case of S-100 negative melanoma: A diagnostic pitfall in the workup of a poorly differentiated metastatic tumor of unknown origin
Anna Biernacka, Konstantinos D Linos, Peter A DeLong, Arief A Suriawinata, Vijayalakshmi Padmanabhan, Xiaoying LiuCytoJournal 2016 13(1):21-21When confronted with a metastatic poorly differentiated tumor of unknown origin, the initial workup includes the standard panel of immunostains to rule out carcinoma, sarcoma, lymphoma, and the greatest mimicker in pathology - malignant melanoma. Although not specific, the S-100 protein is expressed in over 95% of malignant melanomas. Herein, we present a case of multiorgan metastatic malignancy with a dominant hilar and mediastinal mass in a current smoker; clinically, highly...
Source: CytoJournal - September 19, 2016 Category: Pathology Authors: Anna Biernacka Konstantinos D Linos Peter A DeLong Arief A Suriawinata Vijayalakshmi Padmanabhan Xiaoying Liu Source Type: research
Prognostic markers in smear preparations for pancreatic endocrine neoplasms: A cytomorphologic study and statistical analysis of 20 potential prognostic features
Conclusions: A scoring system was developed utilizing mitoses, irregular nuclear membranes, and 3-fold variation in nuclear size to divide smears of pancreatic endocrine tumors into poor and not poor outcome groups. The scoring system achieved 84% accuracy in separating cases into poor and not poor outcomes. (Source: CytoJournal)
Source: CytoJournal - September 19, 2016 Category: Pathology Authors: Lester J Layfield Robert L Schmidt Jack Campbell Magda Esebua Source Type: research
Fine-needle aspiration and core biopsy in the diagnosis of breast lesions: A comparison and review of the literature
Suvradeep Mitra, Pranab DeyCytoJournal 2016 13(1):18-18In recent times, the diagnosis of breast lesions has mostly become dependent on core needle biopsies (CNBs) with a gradual reduction in the rate of performing fine-needle aspiration cytology (FNAC). Both the procedures have their pros and cons and outsmart each other taking into account different parameters. Both the methods are found to be fraught with loopholes, taking into account different performance indices, diagnostic accuracy and concordance, patient benefit, and cost-effectiveness. Unlike the popular belief of an absolute superiority of CNB over FNAC, the lite...
Source: CytoJournal - August 30, 2016 Category: Pathology Authors: Suvradeep Mitra Pranab Dey Source Type: research
Diagnostic relevance of cell block procedure in secondary tumors of the pancreas
Antonio Ieni, Valeria Barresi, Giovanni TuccariCytoJournal 2016 13(1):19-19 (Source: CytoJournal)
Source: CytoJournal - August 30, 2016 Category: Pathology Authors: Antonio Ieni Valeria Barresi Giovanni Tuccari Source Type: research
Stromal tissue as an adjunct tool in the diagnosis of follicular thyroid lesions by fine-needle aspiration biopsy
Conclusion : The preservation of the in vivo architecture of Type 1 is likely due to its elasticity. Recognition of the stromal architecture will likely facilitate the diagnosis. (Source: CytoJournal)
Source: CytoJournal - August 30, 2016 Category: Pathology Authors: Kien T Mai Kevin Hogan Source Type: research
CytoJournal Quiz Cases: Publishing open-access, PubMed-searchable cytopathology cases with educational messages
Katherine G Akers, Vinod B ShidmanCytoJournal 2016 13(1):15-15 (Source: CytoJournal)
Source: CytoJournal - July 26, 2016 Category: Pathology Authors: Katherine G Akers Vinod B Shidman Source Type: research
Fine needle aspiration cytology of cervical lymph node involvement by ovarian serous borderline tumor
Longwen Chen, Kristina A Butler, Debra A BellCytoJournal 2016 13(1):16-16Serous borderline tumor (SBT) involving a cervical lymph node is extremely rare. In addition, fine needle aspiration (FNA) cytology of the involved cervical lymph node shares tremendous morphologic similarity with other low-grade papillary carcinomas. Thus, it can be easily misdiagnosed as metastatic carcinoma. A 42-year-old female had a history of bilateral SBT and postbilateral salpingo-oophorectomy. She presented with left cervical lymphadenopathy 6 months later. FNA cytology showed a low-grade papillary neoplasm with psammoma bodies. Needle core b...
Source: CytoJournal - July 26, 2016 Category: Pathology Authors: Longwen Chen Kristina A Butler Debra A Bell Source Type: research
Tuberculous lymphadenitis: Comparison of cytomorphology, Ziehl-Neelsen staining, and rapid mycobacterial culture at a pediatric superspecialty hospital
Conclusion: FNA is a reliable technique for early and accurate diagnosis of tuberculous lymphadenitis in many cases. Mycobacterial culture by newer rapid techniques can assist in bacillary detection in smear-negative cases and also allows for drug sensitivity testing. Hence, culture should be resorted to in such cases. (Source: CytoJournal)
Source: CytoJournal - July 26, 2016 Category: Pathology Authors: Sonam Mahana Reena Tomar Rawi Agrawal Rushika Saksena Vikas Manchanda Ruchika Gupta Source Type: research
Pleural fluid metastases of myoepithelial carcinoma: A case report and review of the literature
Alicia Calderon Bhambra, Yanhong Zhang, Eric C Huang, John Bishop, Mahan Matin, Alaa AfifyCytoJournal 2016 13(1):13-13Myoepithelial carcinoma (MECA) is one of the rarest salivary gland neoplasms, which may either arise de novo or develop within a preexisting pleomorphic adenoma or benign myoepithelioma. The tumor occurs mainly in the parotid gland followed by minor salivary glands and other body sites. As a result of their morphologic heterogeneity, they can be confused easily with many tumors. Awareness of their unique cytoarchitectural patterns and immunohistochemical profile is crucial for accurate identification. Herei...
Source: CytoJournal - June 9, 2016 Category: Pathology Authors: Alicia Calderon BhambraYanhong ZhangEric C HuangJohn BishopMahan MatinAlaa Afify Source Type: research
Unsatisfactory rate in liquid-based cervical samples as compared to conventional smears: A study from tertiary care hospital
Conclusion: There was a significant reduction of U/S rate in LBC samples as compared to CPS samples, and the difference was statistically significant. The main cause of U/S samples in LBC was low cellularity indicating a technical fault in sample collection. The main cause of U/S rate in CPS was low cellularity followed by low cellularity with excess blood. Adequate training of sample takers and cytologists for the precise cell count to determine adequacy in smears can be of great help in reducing U/S rate. (Source: CytoJournal)
Source: CytoJournal - June 9, 2016 Category: Pathology Authors: Nalini GuptaVikrant S BharArvind RajwanshiVanita Suri Source Type: research
The role of intraoperative scrape cytology in vertebroplasty
Conclusion: Scrape cytology is a simple, rapid, accurate cytodiagnostic technique and should be routinely utilized in vertebral lesions for intraoperative consultation and decision making during vertebroplasty. (Source: CytoJournal)
Source: CytoJournal - May 24, 2016 Category: Pathology Authors: Renuka Venkata InugantiRami Reddy MettuHarsha Vardhan SurathAmarnath Surath Source Type: research
