A Review of Translocation T(6;11) Renal Cell Carcinoma Tumors in the Adult Patient
Historically, T(6;11) renal cell carcinoma (RCC) has been associated with the pediatric and adolescent populations and documentation of this tumor in adults has been rare. However, the frequency of translocation renal cell carcinoma (TRCC) may be widely underestimated in the adult population due to an inadequate immunohistochemical workup or misdiagnosis from similar gross and histological findings to other RCC. A subset of MiT family translocation carcinomas, t(6:11) (p21;q12) translocation tumors cause analpha-TFEB gene fusion. Morphologically, this neoplasm tends to mimic the various types of RCC's, including clear cell...
Source: Current Urology - June 19, 2017 Category: Urology & Nephrology Source Type: research
Is Health-Related Quality of Life after Radical Cystectomy Using Validated Questionnaires Really Better in Patients with Ileal Orthotopic Neobladder Compared to Ileal Conduit: A Meta-Analysis of Retrospective Comparative Studies
Conclusion: This meta-analysis of not-randomized, retrospective comparative studies on the impact of ileal conduit versus IONB on HR-QoL showed a significant advantage of IONB subgroups.Curr Urol 2016;10:57-68 (Source: Current Urology)
Source: Current Urology - June 19, 2017 Category: Urology & Nephrology Source Type: research
Classifying Hydroceles of the Pelvis and Groin: An Overview of Etiology, Secondary Complications, Evaluation, and Management
Conclusion:Due to the range of classifications and etiologies of hydrocele in the pelvis and groin, a deliberate differential diagnosis is essential to avoiding imminent life-threatening complications as well as providing the appropriate treatment.Curr Urol 2016;10:1-14 (Source: Current Urology)
Source: Current Urology - April 12, 2017 Category: Urology & Nephrology Source Type: research
Periurethral Gland Calculus Discovered on Workup for Dyspareunia
A 55-year-old woman with a history of chronic dysuria in the absence of infection was found to have an unusual lesion below the urethral meatus. This was subsequently determined to be a periurethral gland containing a sizeable calculus. Pathologic analysis found the composition to be car bonate apatite (dahllite). Only one prior report of a female periurethral calculus has been noted in the English peer-reviewed literature.Curr Urol 2016;10:55-56 (Source: Current Urology)
Source: Current Urology - April 11, 2017 Category: Urology & Nephrology Source Type: research
Magnetic Resonance Imaging in Hematospermia: Does It Increase Unnecessary Prostate Biopsy?
Introduction: Hematospermia is an uncommon presentation of prostate cancer. Following the introduction of MRI for patients with hematospermia we evaluated its use and effect on prostate biopsy and cancer detection rates.Materials and Methods: Analysis of patients attending our outpatient department over 2 years was undertaken. Diagnostic workup included digital rectal examination and PSA. Those with abnormal findings or persisting symptoms were offered prostate biopsy. In the second year MRI became available for patients with hematospermia. Abnormal MRI or persisting symptoms were offered biopsy. We compared the frequency ...
Source: Current Urology - April 11, 2017 Category: Urology & Nephrology Source Type: research
Microsurgical Subinguinal Varicocele Repair of Grade II-III Lesions Associated with Improvements of Testosterone Levels
Conclusion:Microsurgical subinguinal varicocele repair was associated with a significant improvements of testosterone levels in men with grade II-III lesions and low preoperative testosterone values.Curr Urol 2016;10:45-49 (Source: Current Urology)
Source: Current Urology - April 11, 2017 Category: Urology & Nephrology Source Type: research
Association between Serum Testosterone and PSA Levels in Middle-Aged Healthy Men from the General Population
Introduction:The aim of the present study was to evaluate the association between serum testosterone and PSA levels in middle-aged healthy men from the general population.Materials and Methods:Based on 119 healthy men from the general population, total testosterone and PSA levels were measured. Demographic data regarding BMI, waist-to-hip ratio, smoking, and alcohol consumption were also collected. Men were classified into two groups according to testosterone levels; hypogonadal (testosterone ≤ 12 nmol/l), and eugonadal (testosterone> 12 nmol/l).Results:The mean age of the subjects was 55 years (range 46-60 years). No si...
Source: Current Urology - April 11, 2017 Category: Urology & Nephrology Source Type: research
Post Prostatectomy Vesicourethral Stenosis or Bladder Neck Contracture with Concomitant Urinary Incontinence: Our Experience and Recommendations
Conclusion:Initial management with aggressive BNI followed by implantation of an AUS or male sling when bladder neck is stable is essential to achieve a satisfactory urinary continence outcome.Curr Urol 2016;10:32-39 (Source: Current Urology)
Source: Current Urology - April 11, 2017 Category: Urology & Nephrology Source Type: research
Geriatric Nutrition Risk Index is an Important Predictor of Cancer-Specific Survival, but not Recurrence-Free Survival, in Patients Undergoing Surgical Resection for Non-Metastatic Renal Cell Carcinoma
Conclusion: A low nutritional status evaluated by GNRI may have an unfavorable impact on postoperative cancer control, particularly cancer-specific survival, in non-metastatic RCC patients who received surgical resection.Curr Urol 2016;10:26-31 (Source: Current Urology)
Source: Current Urology - April 11, 2017 Category: Urology & Nephrology Source Type: research
Neuroendocrine Testicular Tumors: A Systematic Review and Meta-Analysis
Conclusion: The diagnosis of testicular carcinoids is based on the immunohistochemistry study. The treatment of choice for these tumors is radical orchiectomy. Somatostatin analogues were reported to be effective in patients with carcinoid syndrome.Curr Urol 2016;10:15-25 (Source: Current Urology)
Source: Current Urology - April 11, 2017 Category: Urology & Nephrology Source Type: research
Angiomyolipoma with Epithelial Cysts Masquerading as a Cystic Renal Cell Carcinoma
We describe the characteristic immunological staining pattern and ultrastructural features of this lesion and discuss the potential differential diagnoses.Curr Urol 2015;9:209-211 (Source: Current Urology)
Source: Current Urology - January 24, 2017 Category: Urology & Nephrology Source Type: research
Delayed Cytoreductive Nephrectomy Following Three Years of Targeted Therapy for Metastatic Renal Cell Carcinoma
We present a 55-year-old male, with good performance status who was diagnosed with a case of metastatic renal cell carcinoma following a pathologic femur fracture. Despite good performance status, multifocal metastases and poor-prognostic features portended a grim prognosis with predicted overall survival of less than nine months. On initial presentation, he was excluded from cytoreductive nephrectomy based on brain metastasis and interleukin-2 was not pursued as the primary tumor was to be leftin situ. The patient was reconsidered for cytoreductive nephrectomy after sustained response to fifth line targeted therapies with...
Source: Current Urology - January 24, 2017 Category: Urology & Nephrology Source Type: research
Expression of Epidermal Growth Factor Receptor and Transforming Growth Factor Alpha in Cancer Bladder: Schistosomal and Non-Schistosomal
Conclusion:EGFR and TGF α could be used as prognostic predictors in early stage and grade of bladder cancer cases, especially those with schistosomal association. In addition they can help in selecting patients who can get benefit from anti-EGFR molecular targeted therapy.Curr Urol 2015;9:192-201 (Source: Current Urology)
Source: Current Urology - January 24, 2017 Category: Urology & Nephrology Source Type: research
Effect of Microsurgical Subinguinal Varicocele Repair on Chronic Dull Scrotal Pain in Men with Grade II-III Lesions
Conclusion: These results indicated that microsurgical varicocele repair should be considered in patients with grade II-III lesions and chronic dull scrotal pain.Curr Urol 2015;9:188-191 (Source: Current Urology)
Source: Current Urology - January 24, 2017 Category: Urology & Nephrology Source Type: research
Is Age an Independent Factor for Prostate Cancer? A Paired Analysis
Conclusion: When assessed separately, without the effects of the main prognostic factors, age does not appear to be an independent prognostic factor for prostate cancer.Curr Urol 2015;9:183-187 (Source: Current Urology)
Source: Current Urology - January 24, 2017 Category: Urology & Nephrology Source Type: research
