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Application of Evolutionary Algorithms for Harmonic Profile Optimization in Symmetric Multilevel Inverter used in Medical Electronic Equipments
Conclusion: The proposed symmetric MLI with evolutionary algorithm based switching is a good choice for medical electronic equipment used in hospital to obtain quality power with minimum THD. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Optimal Placement of FACTS Devices for Voltage Stability Improvement with Economic Consideration Using Firefly Algorithm
Conclusion: The optimal placement, rating and cost of installation of TCSC and SVC in standard IEEE bus systems which enhanced the voltage stability were evaluated in this work. The need of the FACTS devices was also tested during the abnormal cases such as line outage case, generator outage case and overloading case (140%) with the proposed Firefly algorithm. Outputs reveal that the recognized placement of SVC and TCSC reduces the probability of voltage collapse and cost of the devices in the transmission lines. The capability of Firefly algorithm was also ensured by comparing its results with the results of other algorit...
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Real time Processing in Control, Computer Vision and Power Electronics
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Preface
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Meet Our Editorial Board Member
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Acknowledgements to Reviewers
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - September 19, 2018 Category: Molecular Biology Source Type: research

Comparison of Surface Electromyogram Signal for Prosthetic Applications
Conclusion: Finally, the simulation study based on muscle modeling allowed us to explore the parameters that affect the muscle-force relationship prior to prostheses design. Further, the proposed study will also help researchers in understanding the nature of these complex signals particularly in biomedical applications. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - September 19, 2018 Category: Molecular Biology Source Type: research

Performance Analysis of LCL-T Filter Based 2 Stage Single Phase Gird Connected Module with ANN Controller using PV Panel
Conclusion: Hence the paper depicts the structure of non-holonomic robotic vehicle and control with the help of PID controller. The parallel parking scheme has established using MATLAB programming and verified with the help of real time prototype. The paper proposed an idea of automated parking system in contrast to manual parking by the driver. The consumption of space, energy and time are minimized due to the automated parking scheme. Due to human error and negligence, harms such as collisions and accidents are occurred. These harms are reduced by implementing the parallel parking scheme in an intelligent manner. In futu...
Source: Current Signal Transduction Therapy - September 19, 2018 Category: Molecular Biology Source Type: research

Chimeric Antigen Receptors; Their Current and Futuristic Scope
Conclusion: Amongst the most novel approaches, the CAR based research should be focussed on effective tumor targeting with limited toxicity in normal tissues, to improve efficacy with modulation of cell products or host cell products for rapid in vivo expansion. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - September 19, 2018 Category: Molecular Biology Source Type: research

Therapeutic Molecules for Fumigating Inflammatory Tumor Environment
Conclusion: Although, the advanced cancer therapeutics have been established but the combination of different strategies is very important. The efficiency of the treatments depends on the stage of cancer and response of patients. Search for closely defined and selective molecular targets for a particular therapy is very complicated due to heterogenic nature of tumor environment, different therapeutic agents, incubation time, exposure doses and selectivity of therapy. The most promising photodynamic therapy (PDT) and multi- targeted therapies are being established but the question whether the cellular proteins that are most...
Source: Current Signal Transduction Therapy - September 19, 2018 Category: Molecular Biology Source Type: research

Application of Chemoinformatic Tools for the Design of Novel Molecules as anti-Parkinsonian Agents
Conclusion: The works reported by the different groups of authors further help in the identification of the biological pharmacophore of the anti-parkinsonian agents and determine their degree of interaction with the corresponding receptor. However, the literature search made in this review is an exhaustive one and other additional works have also been performed by other different groups of researchers in this field. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - September 19, 2018 Category: Molecular Biology Source Type: research

Integrin Antagonists: A Special Emphasis on Structural Requirements of N-benzoyl-L-biphenylalanines as α4β7 and α4β1 Antagonists
Conclusion: The Open3DQSAR models on both integrins α4β7 and α4β1 were statistically significant. For integrin α4β7 antagonists, the best 3D-QSAR model resulted in an LOO-Q2 of 0.6240 and an R2 Pred of 0.7366 whereas, for integrin α4β1 antagonists, the best model yielded an LOO-Q2 of 0.7487 and an R2 Pred of 0.5366. Important structural features required for higher α4β7 and α4β1 antagonistic activity of N-benzoyl-L-biphenylalanines were highlighted. This study may provide useful information regarding the overall structural aspects of integrins along with better &#...
Source: Current Signal Transduction Therapy - September 19, 2018 Category: Molecular Biology Source Type: research

Signal Transduction through JAK-STAT and NF-κB Regulated Pim-1 Kinase: Novel Target for Anticancer Leads
Conclusion: Incorrect regulation of cytokine-mediated activation of JAK-STAT and NF- B produces abnormal expression of Pim -1 kinase and solid cancer. Phosphorylated JAKs can induce transcription of target genes and NF-κB acts as a regulator of a gene that can control cell proliferation and cell survival. Therefore, JAK-STAT and NF- κB regulated Pim-1 kinase is a novel target for anticancer leads and these leads can be used to design a template as an anticancer agent. Further clinical studies can be carried out to discover new novel congeneric entities. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - September 19, 2018 Category: Molecular Biology Source Type: research

Recent Trends in Design and Developments of New Drugs for the Treatment of Cancer, Rheumatoid arthritis, and Parkinson’s Disease-Associated to Abnormal Signal Transduction
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - September 19, 2018 Category: Molecular Biology Source Type: research

Meet Our Editorial Board Member
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - September 19, 2018 Category: Molecular Biology Source Type: research