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An Adaptive Non Linear filter based on Median of Minimum Distance for Salt and Pepper Noise Removal in Mammogram Images
Conclusion: Exhaustive test results suggest that the ADBMEDUTMF algorithm exhibits very good noise suppression characteristics with minimum error and higher information preservation capability even at very high noise densities in different mammogram images. This makes the algorithm suitable for low level processing. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - February 22, 2018 Category: Molecular Biology Source Type: research

Modulation of Genes Involved in Yeast to Hyphal form Signal Transduction in Candida albicans by Indole and Isatin
Conclusion: Indole and Isatin affected the expression of multiple genes in the yeast to hyphal signal transduction pathway in Candida albicans. In conclusion both Isatin and Indole may represent potential anti-virulence agents against Candida albicans. Indole derivatives could be good candidates for drug repositioning. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - February 22, 2018 Category: Molecular Biology Source Type: research

Targeting Cell Cycle to Suppress Cancer Aggressiveness
Conclusion: There are cross-talks among the diverse neoplastic cell types acting together on cell cycle to ensure survival, growth and metastasis, by inhibiting apoptosis, promoting angiogenesis, and avoiding immune system. Approaches should be undertaken to synergistically block the activation of the interconnected pathways for effective cancer therapy. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - February 22, 2018 Category: Molecular Biology Source Type: research

Exploitable Signaling Pathways for the Treatment of Inflammatory Bowel Disease
Conclusion: An exhaustive study of the above mentioned signaling pathways and their influence on the inflammatory process in IBD may simplify the expertise in the homeostasis of gastrointestinal tract and aid in unveiling new avenues for the treatment of IBD. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - February 22, 2018 Category: Molecular Biology Source Type: research

Positive and Negative Effects of TGF-β Signaling Pathways in Carcinogenesis
Conclusion:TGF-β signaling pathways have a multifaceted and fundamental role in human development. It acts as a double-edged sword, both tumor suppressor, and tumor promoter. The tumor suppressor role is commonly designated as antiproliferative and apoptotic effects. TGF-β stops cell cycle at the G1 phase and promotes apoptosis. However, in advance stage of the tumor, it lost suppressor activities and begin tumor promotor due to the mutation in some component of the TGF-β pathway. Thus, The TGF-β can no longer control the cell cycle and proliferate the cancer cell. The increased production of TGF-β...
Source: Current Signal Transduction Therapy - February 22, 2018 Category: Molecular Biology Source Type: research

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Source: Current Signal Transduction Therapy - February 22, 2018 Category: Molecular Biology Source Type: research

System Study of Vascular Smooth Muscle Cell (VSMC) Activation-Related Signaling Pathways by Monocyte and Macrophage Cells
Conclusion: The cytokine-cytokine receptor interaction, focal adhesion and regulation of actin cytoskeleton pathways were suggested to be involved in VSMC proliferation and migration by extracellular monocyte and macrophage proteins. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - May 9, 2017 Category: Molecular Biology Source Type: research

Pretreatment Serum Fibrinogen Levels are Associated with Postoperative Distant Metastasis and Prognosis of Resected Lung Cancer Patient: A Retrospective Study
This study investigated the correlation of preoperative plasma fibrinogen level with distant metastasis and prognosis in lung cancer patients. Methods: A total of 139 lung cancer patients who underwent curative surgery between January 2009 and November 2010 were enrolled in this study. In addition to clinical and pathological prognostic factors, we evaluated the prognostic value of plasma fibrinogen on distant metastasis and relapse. Univariate analysis was performed using the Kaplan-Meier survival analysis and multivariate analysis was performed using the Cox regression model in order to measure 5-year distant metastasisf...
Source: Current Signal Transduction Therapy - May 9, 2017 Category: Molecular Biology Source Type: research

A Novel Approach for the Reduction of 50Hz Noise in Electrocardiogram Using Variational Mode Decomposition
Conclusion: This paper provides a novel method in the area of denoising Biosignals. Two techniques are proposed for denoising such as direct subtraction and indirect subtraction techniques. A comparative study is performed to study the performance of the proposed method. The parameters used for comparison are MSE, SNR, PRD and PSNR. Indirect subtraction technique outperforms the direct subtraction method. An improved SNR value and minimized MSE indicates the performance of denoising method. Thus VMD based subtraction techniques give better denoised signals even though the decomposition process takes time. (Source: Current ...
Source: Current Signal Transduction Therapy - May 9, 2017 Category: Molecular Biology Source Type: research

A New Approach for Skin-Derived Precursors to Ameliorate Skin Photodamage Through Activation of Nrf2 Signaling Pathway
Conclusion: Together the above data, we speculate that SKPs may be good candidates for control of skin photodamage through activating Nrf2 and its signaling pathway. These would provide a new approach for resisting skin photodamage. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - May 9, 2017 Category: Molecular Biology Source Type: research

Molecular Switch of AhR in Repression or Activation of Stem Cell Signaling
Conclusion: AhR may inhibit or promote stem cell/cancer stem cell signaling through molecular switches of ageing, tissue specific signaling, ligand, and systems interaction networks. Targeting these signaling would provide a new avenue for efficient therapy in precision medicine. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - May 9, 2017 Category: Molecular Biology Source Type: research

Toll-Like Receptor 4 Signaling Pathway as a Potential Targets for Stroke-Induced Inflammation
Toll-like receptor 4 (TLR4) belongs to a large family of pattern recognition receptors that play a key role in innate immunity and inflammatory response. Increasing evidence has shown that TLR4 signaling pathway plays an essential role in mediating the immune response and central nervous system (CNS) repair and development. Brain inflammation and innate immunity has been implicated as a secondary injury mechanism following stroke, exacerbating neural damage to impede recovery. After stroke, a series of signaling pathways are triggered by dying cells or other factors in both the local innate immune cells in brain and other ...
Source: Current Signal Transduction Therapy - May 9, 2017 Category: Molecular Biology Source Type: research

Remodelling of the Ca2+ Toolkit in Tumor Endothelium as a Crucial Responsible for the Resistance to Anticancer Therapies
Conclusions: Understanding the impact of Ca2+ dysregulation in tumor vascularization is mandatory to circumvent patient refractoriness to current anti-cancer regimens. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - May 9, 2017 Category: Molecular Biology Source Type: research

EDITORIAL: Novel Signaling Pathway Based Therapeutics in Cancer and Other Diseases
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Source: Current Signal Transduction Therapy - May 9, 2017 Category: Molecular Biology Source Type: research

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Source: Current Signal Transduction Therapy - May 9, 2017 Category: Molecular Biology Source Type: research