Pretreatment Serum Fibrinogen Levels are Associated with Postoperative Distant Metastasis and Prognosis of Resected Lung Cancer Patient: A Retrospective Study

This study investigated the correlation of preoperative plasma fibrinogen level with distant metastasis and prognosis in lung cancer patients. Methods: A total of 139 lung cancer patients who underwent curative surgery between January 2009 and November 2010 were enrolled in this study. In addition to clinical and pathological prognostic factors, we evaluated the prognostic value of plasma fibrinogen on distant metastasis and relapse. Univariate analysis was performed using the Kaplan-Meier survival analysis and multivariate analysis was performed using the Cox regression model in order to measure 5-year distant metastasisfree survival (DMFS), locoregional relapse-free survival (LRFS), relapse-free survival (RFS), and overall survival (OS). Results: Median plasma fibrinogen level was 3.59 g/L (range: 1.92-8.73 g/L). A total of 86 patients (61.9%) had normal plasma fibrinogen levels (4 g/L). Pearson’s chi-square test showed that plasma fibrinogen level was significantly associated with age (P=0.047), tumor stage (P
Source: Current Signal Transduction Therapy - Category: Molecular Biology Source Type: research