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Harmine Induces Gastric Cancer Cell Apoptosis through the ROSmediated PI3K/AKT Signaling Pathway
This study evaluated the antitumor effects of HM in human gastric cancer in vitro. The in vitro cytotoxicity test indicated that HM inhibits gastric cancer cell viability in a dose- and time-dependent manner. Intracellular ROS production was measured using the fluorescent substrate DCFH-DA. The percentage of apoptotic cells was determined by flow cytometry analysis and DAPI staining. Western blot analysis showed the expression of p-AKT, Bcl-2, Bax and caspase-3 in SGC-7901 cells treated with various agents. We demonstrated that HM induces gastric cancer cell apoptosis through the ROS-mediated PI3K/AKT signaling pathway. Th...
Source: Current Signal Transduction Therapy - December 21, 2015 Category: Molecular Biology Source Type: research

The Protective Effects and Mechanism of Resveratrol-loaded Nanoparticles on HK-2 Cells Suffering from Hypoxia-reoxygenayion
Kidney ischemia-reperfusion injury is a serious illnesses which could threaten to human health. However, there is lack of effective therapy for the disease. Recently, resveratrol (Res) has been reported as a potential antioxidant in treatment of ischemia/reperfusion injury through attenuating oxidative stress and apoptosis. Because of its insolubility and short half-time, the application of Res is limited. Latest evidence reveals the possibility of developing nanoparticle-based delivery systems with improved solubility, stability and cytotoxicity of lipophilic drug. Here, we use Res-loaded nanoparticles (Res-NPs) to evalua...
Source: Current Signal Transduction Therapy - December 21, 2015 Category: Molecular Biology Source Type: research

Enhanced Neuroprotection of Ischemic Stroke Based on Liposomal Drug Delivery System Loading a Novel Uncoupler of Ischemia-induced nNOSPSD- 95
In conclusion, LPs had been demonstrated to be a promising drug delivery system for ZL006 to treat ischemic stroke. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - December 21, 2015 Category: Molecular Biology Source Type: research

Nano-Tetrandrine Efficiently Inhibits the Proliferation and Induces the Apoptosis of Hep2 Cells through a Mitochondrial Signaling Pathway
Tetrandrine (Ted) has been demonstrated in a series of studies to have potential antitumor effect against several cancers. Its lipophilicity makes it an ideal model drug for nanoparticle encapsulation. We constructed Ted loaded nanoparticles (Ted-NP) with PLGA-PEG as drug carrier. Characterization of the nanoparticles showed that Ted-NP had a size of less than 100 nm and a slight negative surface charge. By adjusting the feeding ratio, the highest drug loading content and encapsulation efficiency were 13.6% and 87.2%, respectively. In vitro release indicated the sustained release pattern of Ted-NP. In vitro cytotoxicity te...
Source: Current Signal Transduction Therapy - December 21, 2015 Category: Molecular Biology Source Type: research

Self-assembling Peptide Nanofibers Containing D-amino Acids for Tetrandrine Delivery
Self-assembling peptides have very recently emerged as a new class of drug vehicles, as they hold unique advantages such as good biocompatibility, design flexibility, and controllable nanotructure. In this work, we report a self-assembling peptide containing D-amino acids (Nap- GDFDFDYGRGD) as the carrier of anticancer drug tetrandrine. Tetrandrine is a bis-benzylisoquinoline alkaloid isolated from the root of Hang-Fang-Chi (Stephania tetrandra S. Moore). The D-peptides were employed in this study as they have shown stronger resistance against proteases than their Lcounterpart with natural L-amino acids. The Nap-GDFDFDYGRG...
Source: Current Signal Transduction Therapy - December 21, 2015 Category: Molecular Biology Source Type: research

Editorial (Thematic Issue: Special Issue on Herbal Medicines and Nano-Drug Delivery Systems)
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Source: Current Signal Transduction Therapy - December 21, 2015 Category: Molecular Biology Source Type: research

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Source: Current Signal Transduction Therapy - December 21, 2015 Category: Molecular Biology Source Type: research