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Synchronization Based on Node Balance Set for Energy Conservation in Wireless Sensor Networks
Conclusion: Hypothetical study and experimental simulations are studied by various performance evaluation metrics namely clock offset, number of transmitted messages, delayed messages and Residual Energy. The results confirm that clustering with node balance set saves more energy in WSN and also it reduces synchronization errors. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

To Minimize Fault Report and Bug Fixing Time using an Efficient Integration of Instance and Aspect Preferment Algorithm
Conclusion: The proposed technique helps to validate & verify software application in effective way. Reduction of data on fault triage aims to construct a high-superiority set of fault data in the small-scale system through eliminating the fault report. To applying an algorithm, fault data set and attributes are extracted from every fault data set and train a predictive model based on the historical dataset. Based on Experimental evaluations, proposed methodology reduces 0.06 ET (Execution Time), and improves 0.5 P (Precision), 0.75 R (Recall), 0.39 F-M (F-Measure) and 5.07% (accuracy) compared than existing methodologies....
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

Recent Innovations in Soft Computing Applications
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

Current Therapy and Computational Drug Designing Approaches for Neurodegenerative Diseases -with Focus on Alzheimer’s and Parkinson’s.
Conclusion: The findings of this review confirm that therapies and current successful strategies for neurodegenerative disease are mainly symptomatic. Current research is mainly focused on preventing the progress of neurodegeneration. Various in silico techniques; ligand-based methods such as QSAR, virtual screening, pharmacophore mapping and structure-based methods such as homology modeling, docking studies have been used to identify therapeutic compounds for Alzheimer’s and Parkinson’s. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

Novel Target Sites for Drug Screening: A Special Reference to Cancer, Rheumatoid Arthritis and Parkinson’s Disease
Conclusion: Alteration of signal transduction by a drug is the goal of chemogenomics, a new branch formed by combination of chemistry and genomics. The proliferation, angiogenesis and apoptosis of cancer cells are regulated by cellular signaling of transcription factors, protein kinases, transmembrane receptors, extracellular ligands and some external factors like oncogenic mutations, ubiquitin-proteasome pathway with epigenetic changes. Traditional anticancer drugs either alter DNA synthesis or control cell division while new drugs retard tumor growth or induce apoptosis. The deterioration of dopaminergic neurons in subst...
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

1,3,5-Triazine Analogs: A Potent Anticancer Scaffold
Conclusion: Various 1,3,5-triazine analogs have shown potent activities and may be regarded as clinical candidates for future anticancer formulations. This review may be helpful to those researchers seeking required information with regard to the drug design and medicinal properties of 1,3,5-triazine derivatives for selected targets. This review may also offer help to find and improve clinically viable anticancer molecules. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

Recent Drug Targets Associated to Abnormal Signal Transduction Mediated Cancer, Rheumatoid Arthritis, Alzheimer’s and Parkinson’s disease
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

Meet Our Editorial Board Member
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

Design and Evaluation of a Modulated TENS Stimulation in Medical Pain Therapy
Conclusion: The first results clinically observed in the PWM-TENS technique are encouraging. The findings of this study confirm that this noninvasive strategy is suitable and useful for acute pains coming from the nociceptive, neuropathic and musculoskeletal origin. However, its efficiency is moderated and less adapted for low back pain. The experiments make it possible to estimate whether this modulated TENS method could improve existing anti-pain therapies, taking into account objective and subjective evaluation criteria. But this study must be followed by large population samples to answer all the problems of acute and ...
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

IoT based Low Power Wearable ECG Monitoring System
Conclusion: We have proposed a wireless wearable ECG monitoring system enabled with an IoT platform that integrates heterogeneous nodes of ECG sensor and applications, has a long battery life and provides a high-quality ECG signal. The system allows monitoring single/multiple patients on a relatively large indoor area (home, building, nursing home, etc). As observed, this result is obtained through a careful set of choices at the level of components, circuit solutions, and algorithms. We would like to stress the fact that a dedicated overall output is not enough to achieve an advantage in terms of overall sensor performanc...
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Proteome Analysis Revealed Jak/Stat Signaling and Cytoskeleton Rearrangement Proteins in Human Lung Epithelial Cells During Interaction with Aspergillus terreus
Conclusion: Our study has contributed to understand the interaction response of human lung epithelial cells during A. terreus infection. Also, our study may facilitate the identification of inflammatory biomarker against A. terreus. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Targeting Negative Regulators of TRIF-dependent TLR Signaling Pathway as a Novel Therapeutic Strategy
Conclusion: We proposed that the manipulation of TRIF signaling pathway via targeting its negative regulators could be used as an approach to modulate the functions of this pathway without undesired toxic proinflammatory responses. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

ANN-based Maximum Power Point Tracking for a Large Photovoltaic Farm Through Wireless Sensor Networks
Conclusion: A wireless network based insulation monitoring has been done. An ANN based MPPT algorithm has been developed that gives the reference MPP voltage. The sliding mode control scheme uses the reference voltage and produces the switching pulses for the POLC. The ANN had been trained with a number of combinations of different insulation values falling on each of the forty panels and the ANN gives the correct reference voltage for any combination of insulation levels that were not used while training. The sliding mode controller uses this reference voltage and gives the switching pulses to the POLC that harvests the m...
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Design and Implementation of High Power LED Lighting System for Health Care Applications
Conclusion: This manuscript suggests a modified single switch SEPIC LED driver for 48V output operated healthcare equipment. Simulation study of this driver shows the better performance. In order to analyze the performance, a comparative study was conducted by using the classical PI and the novel PI integrated fuzzy controller. Satisfactory results regarding enhanced quality of power, regulated load voltage, quick rise time and settling time were achieved. The source current THD has been reduced to around 1.39% which is less than 5% as per the IEEE-516 prescribed standard and the power factor has been improved to 0.9995 by...
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Anfis Classifier Based Moving Object Detection and Segmentation in Indoor and Outdoor Environments
Conclusion: In this paper, moving object is detected and segmented using ANFIS classifier. The proposed method initially segments the background image and then features are extracted from the threshold image. These features are trained and classified using ANFIS classification method. The proposed moving object detection method is tested on different video sequences which are obtained from different indoor and outdoor environments. The performance of the proposed moving object detection and segmentation methodology is analyzed in terms of Accuracy, Recall, Average Accuracy, Precision and F-measure. (Source: Current Signal ...
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research