Signal Transduction through JAK-STAT and NF-κB Regulated Pim-1 Kinase: Novel Target for Anticancer Leads

Conclusion: Incorrect regulation of cytokine-mediated activation of JAK-STAT and NF- B produces abnormal expression of Pim -1 kinase and solid cancer. Phosphorylated JAKs can induce transcription of target genes and NF-κB acts as a regulator of a gene that can control cell proliferation and cell survival. Therefore, JAK-STAT and NF- κB regulated Pim-1 kinase is a novel target for anticancer leads and these leads can be used to design a template as an anticancer agent. Further clinical studies can be carried out to discover new novel congeneric entities.
Source: Current Signal Transduction Therapy - Category: Molecular Biology Source Type: research