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Exome-wide pharmacogenomic analysis of response to thiopurines in inflammatory bowel disease patients
Conclusion: These findings might help to understand the biological mechanisms behind thiopurine treatment failure and to tailor treatment for individual inflammatory bowel disease patients. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - December 29, 2015 Category: Genetics & Stem Cells Source Type: research

Lanthenide-Doped Nanophosphor labels for Protein Microarrays
Conclusion: These novel nanophosphors-based labels have potential to overcome several limitations of existing labels and hence could be employed for the protein microarrays applications. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - December 29, 2015 Category: Genetics & Stem Cells Source Type: research

Genomic Approaches and Oxygen Radical Measurement as Biomarker Candidates of Off-Season Predictor of Pollinosis: A Pilot Study
Conclusion: New measurement technique and methodology may elucidate pollinosis patients in their prediction and prevention and may contribute to development of preventive medicine. It is only a pilot study with small sample, but might have possibilities of finding a cut end and a breakthrough in the difficulty of allergic pathophysiology from the viewpoint of genomic approach and radical oxygen measurement. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - December 29, 2015 Category: Genetics & Stem Cells Source Type: research

Pharmacogenetic Polymorphisms in a Portuguese Gypsy Population
Conclusion: From the pharmacogenetic point of view, the Gypsies from Portugal do not seem to raise additional public health concerns comparatively to other Portuguese. This study illustrates how important signs of the demographic past of a population can be captured by the fraction of pharmacogenetically relevant genetic diversity. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - December 29, 2015 Category: Genetics & Stem Cells Source Type: research

“Self-Antigenic Universe” and Tuberculosis Vaccine Development
Conclusion: The immune response induced by antigens/epitopes present in SAU could have carrier effect and elicit specific effector and/or regulatory immune responses potentially useful for the development of new vaccines. This aspect should be considered for the development of tailored vaccines with superior efficacy for the prevention of TB. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - December 29, 2015 Category: Genetics & Stem Cells Source Type: research

Nutraceutical: A Drug, Dietary Supplement and Food Ingredient
Conclusion & Future: With an aim to improve the quality of life at present, nutraceutical represents the fastest-growing segment of today’s food industry. The future is centered on the newly designed foods stocked at the supermarkets providing a better standard of life, giving a healthier way of living to people reaching throughout the world. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - December 29, 2015 Category: Genetics & Stem Cells Source Type: research

Pharmacometabolomics: Applications and Challenges
Conclusion: The merge of pharmacogenomics with pharmacometabolomic data, rapidly and efficiently, remains a significant challenge. No doubt, a “pharmacometabolomics-informed pharmacogenomic” strategy is anticipated to enable our in-depth understanding of individual variations in drug response phenotypes and hence, the design of individualized therapeutic approaches via the prediction of metabotypes. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - December 29, 2015 Category: Genetics & Stem Cells Source Type: research

Evaluation of Vitamin C as a Personalized Adjuvant Medicine: Pharmacogenomic Studies
Conclusion: From the information available, it seems clear that vitamin C is involved in a variety of disease mechanisms. This review might provide an evaluation of vitamin C as a personalized adjuvant medicine. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - December 29, 2015 Category: Genetics & Stem Cells Source Type: research

Preface
(Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - December 29, 2015 Category: Genetics & Stem Cells Source Type: research

Meet Our Editorial Board Member
(Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - December 29, 2015 Category: Genetics & Stem Cells Source Type: research

Acknowledgement to Reviewers
(Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - December 11, 2015 Category: Genetics & Stem Cells Source Type: research

Tyrosine Kinase Inhibitor Resistance and Epigenetic Regulation of SHP1 Phosphatase Expression in Chronic Myeloid Leukemia
This study addresses a mechanism of resistance observed in the absence of mutations. During TKI challenge, of downstream dephosphorylators such as Protein-Tyrosine Phosphatase, Nonreceptor-Type 6 (PTPN6 or SHP1) may supplement oncogenic activation. We retrospectively examined expression and control of SHP1 in TKI sensitive and resistant cases of CML in 122 North American patients of European and African ancestry employing mutation detection, methylation analysis and gene expression. Mean SHP1 gene expression was lower in CML cases (SHP1/beta2 microglobulin% = 399.4) than in nonleukemic samples (SHP1/beta2 microglobulin% = ...
Source: Current Pharmacogenomics and Personalized Medicine - December 11, 2015 Category: Genetics & Stem Cells Source Type: research

Allele Frequency Distributions of the Drug Metabolizer Genes CYP2C9*2, CYP2C9*3, and CYP2C19*17 in the Buginese Population of Indonesia
The present study is part of the genetic mapping of Indonesia focusing on drug metabolizing enzymes, which started with the Buginese population of Makassar, South Sulawesi. The two CYP450 gene subfamilies, i.e. CYP2C9 and CYP2C19 are of interest as they exhibit wide inter-individual variation in expression, which influence the drug metabolism capacity. The CYP2C9 alleles of interest in this study were CYP2C9*2 and *3, and of CYP2C19 was CYP2C19*17. The study aimed to determine the frequencies of the CYP2C9 genotype, which contains *1, *2 and *3 alleles, and the CYP2C19 genotype, which comprises the *1 and *17 alleles in th...
Source: Current Pharmacogenomics and Personalized Medicine - December 11, 2015 Category: Genetics & Stem Cells Source Type: research

Renin Angiotensin System Gene Polymorphisms in Response to Antihypertensive Drugs and Visit-To-Visit Blood Pressure Variability in Essential Hypertensive Patients
The renin-angiotensin system (RAS) genes polymorphism have been associated with blood pressure (BP) response to antihypertensives drugs and may also influence the variability in visit-tovisit BP. Here we have investigated the association of RAS gene polymorphism with response to three classes of antihypertensive drugs (atenolol, amlodipine and enalapril) and also with genetic factor which may influence the variability in visit-to-visit BP. Total of 230 participants of south Indian ethnicity under the medication of any of these three classes of drugs were enrolled. The four polymorphisms analyzed were AGT M235T (rs699), ACE...
Source: Current Pharmacogenomics and Personalized Medicine - December 11, 2015 Category: Genetics & Stem Cells Source Type: research

Systematic 3D Screening of Amino Acid Mutations in Pharmacogenes
In this study, we selected 48 genes identified as “Very Important Pharmacogenes (VIPs)” by the PharmGKB database, and developed a fivefeature Structural Disturbance Score (SDS) for their amino acid variants. “SDS Pharmacogenes” is a score that categorizes distinguishable characteristic profiles that annotate VIP variants as functional rather than neutral mutations. Unlike most existing conservation-based measures, SDS Pharmacogenes can be used to evaluate unknown variants of currently 45/48 VIPs and predict the degree to which each one will have strong impacts towards pharmacogenomics, potentially aiding optimizati...
Source: Current Pharmacogenomics and Personalized Medicine - December 11, 2015 Category: Genetics & Stem Cells Source Type: research