Current Pharmacogenomics and Personalized Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Peculiaritie of Distribution of Polymorphic Variants of IL1Β Gene in Patients with Atherosclerosis and Metabolic Syndrome
Conclusion: The risk of development of AS in the background of MS is increased in carriers of combinations of SNPs (-31)TT/(+3953)CT IL1В gene responsible for hyperproduction of this cytokine. In this connection, further studies of the association of genes with MS and AS components should focus on intergenic interactions. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - April 28, 2020 Category: Genetics & Stem Cells Source Type: research

The Promise of Whole-exome Sequencing for Prenatal Genetic Diagnosis
Prenatal genetic diagnosis provides information for pregnancy and perinatal decision- making and management. Cytogenetic testing methods, including chromosomal microarray analysis and gene panels, have evolved to become a part of routine laboratory testing, providing valuable diagnostic and prognostic information for prenatal diagnoses. Despite this progress, however, cytogenetic analyses are limited by their resolution and diagnosis is only possible in around 40% of the dysmorphic fetuses. The advent of nextgeneration sequencing (NGS), whole-genome sequencing or whole-exome sequencing has revolutionized prenatal diagnosis...
Source: Current Pharmacogenomics and Personalized Medicine - April 28, 2020 Category: Genetics & Stem Cells Source Type: research

Pharmacokinetics and Systems Pharmacology of Anti-CD47 Macrophage Immune Checkpoint Inhibitor Hu5F9-G4
Conclusion: Taken together, we review the pharmacokinetics and systems pharmacology of Hu5F9-G4 which appears to hold great promise for the future of cancer care. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - April 28, 2020 Category: Genetics & Stem Cells Source Type: research

Validation of Traditional Medicinal Practices Through Modern Scientific Approach: A Case for Reconsideration
(Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - April 28, 2020 Category: Genetics & Stem Cells Source Type: research

HLA-B27 is a Risk Factor for Rheumatoid Arthritis: Suggestion for an Evidence-based Update
Previously, the association of human leukocyte antigen (HLA)-B27 with ankylosing spondylitis has been investigated as original and meta-analysis studies. However, the association of HLA-B27 with rheumatoid arthritis is not currently investigated as a meta-analysis. Hence, in this letter, a brief meta-analysis on this association will be performed. Although there were some studies on the association of RA and HLA-B27, however, there was not a pooled odds ratio reported in textbooks. Based on this brief metaanalysis, number 2.687 can be reported as the odds ratio of this association. It shows that this association is neither...
Source: Current Pharmacogenomics and Personalized Medicine - April 28, 2020 Category: Genetics & Stem Cells Source Type: research

Towards a Mature Discipline of Pharmacogenomics: Epistemological Reflections
(Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - April 28, 2020 Category: Genetics & Stem Cells Source Type: research

Meet Our Regional Editor
(Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - April 28, 2020 Category: Genetics & Stem Cells Source Type: research

Acknowledgements to Reviewers
(Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - January 24, 2019 Category: Genetics & Stem Cells Source Type: research

Association between Paraoxonase 1(PON1) Gene Polymorphisms and PON1 Enzyme Activity in Indian Patients with Coronary Artery Disease (CAD)
Conclusion: The study shows that the PON1-192R allele is strongly associated with CAD patients and affects serum PON1 activity toward paraoxon, implying a higher likelihood of development and/or progression of CAD among Indians. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - January 24, 2019 Category: Genetics & Stem Cells Source Type: research

Computational Studies of Molecular Targets Regarding the Adverse Effects of Isoniazid Drug for Tuberculosis
Conclusion: The results of this study are consistent with and rationalize earlier biochemical, molecular and clinical studies that relate prevalence of isoniazid induced adverse effects to genetic polymorphisms in NAT2, GSTT1, GSTM1 and CYP*. The computational results of this study indicate that MAO, COMT and NNMT are additional potential targets related to variation in isoniazid induced adverse effects. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - January 24, 2019 Category: Genetics & Stem Cells Source Type: research

Molecular Mechanism of Metformin Associated Lactic Acidosis (MALA)- an In Silico Exploration
Conclusion: Based on these predicted interactions and organ specific gene expression data in the databases, we present here a model to explain the molecular mechanism of MALA. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - January 24, 2019 Category: Genetics & Stem Cells Source Type: research

Metabolomics-based Approach to Pharmacotherapy Personalization: Advantages and Limitations
Conclusion: The perspective ways for solution of limitations of the metabolomics-based approach are considered. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - January 24, 2019 Category: Genetics & Stem Cells Source Type: research

Drug Abuse Treatment through Gene Manipulation Using Nanomedicine
Conclusion: Nanoparticles with low toxicity, high gene transmission efficiency and high bio-compatibility were found to have important application in the combination of diagnosis and treatment in addiction gene therapy, and to cause behavioral changes during drug abuse. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - January 24, 2019 Category: Genetics & Stem Cells Source Type: research

Oxidative Stress as a Key Signaling Pathway in Placental Angiogenesis Changes in Preeclampsia: Updates in Pathogenesis, Novel Biomarkers and Therapeutics
Conclusion: Understanding the dynamics of preeclampsia will create a window of opportunity for predictive, preventive and personalised medicine (PPPM). (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - January 24, 2019 Category: Genetics & Stem Cells Source Type: research

Meet Our Editorial Board Member
(Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - January 24, 2019 Category: Genetics & Stem Cells Source Type: research