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Individualized Cancer Therapy, Future Approaches
Conclusion: A reliable, safe, effective and collective platform can be established through further scientific and technical approaches in the clinic. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - November 12, 2018 Category: Genetics & Stem Cells Source Type: research

A Prospective Observational Pilot Study of Adverse Drug Reactions in Patients Admitted in the Geriatric Ward of a Tertiary Hospital in North India
Conclusion: A higher than described incidence of ADRs was seen in our study. Polypharmacy was observed as a universal association. Antibiotics and diuretics were the common culprits. A greater fraction of ADRs is avoidable by proper vigilance and adequate monitoring. Awareness about the culprit drugs and associated regional variations may help in avoiding them in the older patients of specific ethnicities. The study highlights the incidence, severity and type of ADRs in the north Indian elderly population and gives platform for large-scale studies in future. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - November 12, 2018 Category: Genetics & Stem Cells Source Type: research

Evaluation of Estrogen Receptor α and ß Genes Expression in Normal and Neoplastic Mammary Gland in Dogs by Real-time PCR
Background: Estrogen and progesterone play a key role in mammary tumorigenesis of female dogs. Malignant tumors are considered hormone-dependent neoplasms, which may reappear after surgical removal or might spread to other organs such as liver, lymph nodes, and lungs. Objective: The purpose of this study was to evaluate the expression of estrogen receptor α and ß genes in normal and neoplastic mammary glands of female dogs. Methods: Ten neoplastic tumors (benign and malignant) and 10 normal samples were selected. After RNA extraction and cDNA synthesis, ERα and ERβ genes were amplified by Real-time PCR base...
Source: Current Pharmacogenomics and Personalized Medicine - November 12, 2018 Category: Genetics & Stem Cells Source Type: research

Regulation of LDLR, Bcl-2 and FASN Expressions by Oxidized Low Density Lipoprotein in Estrogen Receptor Positive Breast Cancer Cells
Conclusion: Results of this study suggest that TQ modulates oxLDL-induced expression of markers in breast cancer growth. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - November 12, 2018 Category: Genetics & Stem Cells Source Type: research

Enhanced Sensitivity of Lymphoid Cells to Ethanol ADH Acetaldehyde Toxicity; Implications for GDEPT and Adoptive T Cell Therapy
Conclusion: The ethanol ADH acetaldehyde system offers a simple, safe, non-toxic approach to cancer therapy prodrug toxin technology. It may also offer a safe and non-toxic system to control the number and action of T cells used in adoptive immunotherapy. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - November 12, 2018 Category: Genetics & Stem Cells Source Type: research

Current Clinical Application and Response Prediction Biomarkers of PARP Inhibitors
Recently, novel drugs that inhibit the enzyme poly (ADP-ribose) polymerase (PARP) based on the concept of synthetic lethality are used for cancer treatment. Three PARP inhibitors (olaparib, rucaparib and niraparib) are approved for the treatment of recurrent ovarian cancer in the US or Europe, while another two (veliparib and talazoparib) showed promising anti-cancer activity. This review aims to summarize the current status of clinical trials on PARP inhibitors and then discusses studies aimed to identify biomarkers for predicting the efficacy of PARP inhibitors. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - November 12, 2018 Category: Genetics & Stem Cells Source Type: research

Non-B DNA Structures as Candidate Drug Targets Against Structural Chromosomal Instability
Conclusion: Hairpin/cruciform or slipped-strand DNA structures extruded by inverted and direct repeats, respectively, could be involved in the induction of translocations, deletions, isochromosomes, duplications and inversions in human cancers and genetic diseases as well as the expansion of short nucleotide repeats in hereditary neurological diseases. In addition, there is a significant association between long inverted repeats (LIRs) and the breakpoint regions of gross gene deletions in human cancers and inherited diseases. Thus, this review will focus on non-B DNA structures as candidate drug targets against structural ...
Source: Current Pharmacogenomics and Personalized Medicine - November 12, 2018 Category: Genetics & Stem Cells Source Type: research

Effects of Propolis and Caffeic Acid Phenethyl Ester (CAPE) on Breast Cancer Cells
Conclusion: Propolis extracts may be important economically, allowing a relatively inexpensive cancer treatment associated to lower concentrations of drugs. In this review, the activity and mechanisms of action of propolis and CAPE on breast cancer cells are discussed. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - November 12, 2018 Category: Genetics & Stem Cells Source Type: research

Meet Our Associate Editor
(Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - November 12, 2018 Category: Genetics & Stem Cells Source Type: research

The Gut Microbiota in Cardiovascular Diseases: From Biomarkers and Potential Targets to Personalized Interventions
This study discusses the crucial factors responsible for the progression of atherosclerotic cardiovascular disease (CVD). The interaction between the gut microbiota, heart and vessels in CVD pathogenesis is extremely complex and includes components such as direct bacterial translocation from the gut to vessels and metabolitemediated damage. To a greater extent, CVD seems to be entangled with a subtle immune system-to-microbiota interface. From among the most significant advances in recent years in this area, it is necessary to highlight the discovery of the pro-atherogenic effect of trimethylamine-N-oxide (TMAO) and change...
Source: Current Pharmacogenomics and Personalized Medicine - July 16, 2018 Category: Genetics & Stem Cells Source Type: research

Revisiting the in-vitro Assays for Antifungal Evaluation of Natural Products
Conclusion: The importance of design and implementation of antifungal susceptibility testing methods is necessary to evaluate and exploit the diversity of natural products. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - July 16, 2018 Category: Genetics & Stem Cells Source Type: research

Herbal Drug Discovery: Challenges and Perspectives
The objective of this review article is to summarize the importance of plants in drug discovery, current perspectives and challenges. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - July 16, 2018 Category: Genetics & Stem Cells Source Type: research

Alternative to Antibiotics from Herbal Origin – Outline of a Comprehensive Research Project
Conclusion: Following the way of proposed thorough research, a new type of herbal medicine based treatment system may be started and an opportunity for the establishment of export-oriented agro - medicine industries may be created. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - July 16, 2018 Category: Genetics & Stem Cells Source Type: research

Pharmacovigilance in Ayurveda – Concept and Regulations
Background: The Indian system of medicine has its origin in India and has been practiced since centuries in India and its neighbouring South East Asian countries. Mostly the practice of this system of medicine is believed to be the safest form of therapy, however, incidences of adverse drug reactions owing to the consumption of traditional drugs led to the origin of pharmacovigilance of Ayurvedic drugs. The Concept of Pharmacovigilance: Pharmacovigilance is the science of detection, understanding, assessment and prevention of adverse drug reactions and related untoward effects. Concepts and Regulations of Pharmacovigilance...
Source: Current Pharmacogenomics and Personalized Medicine - July 16, 2018 Category: Genetics & Stem Cells Source Type: research

Validation of Traditional Medicinal Practices through Modern Scientific Tools and Techniques
(Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - July 16, 2018 Category: Genetics & Stem Cells Source Type: research