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Pharmacogenetics in Methadone Therapy
Methadone, a synthetic opioid, is mainly used as an analgesic and a maintenance antiaddictive and reductive preparation in the treatment of opioid dependence. A better understanding of the factors underlying individual responses to methadone is required in order to improve treatment individualization, thereby potentially leading to better clinical efficacy. Evidence now suggests that pharmacogenetics has a role in the effects of methadone medications, and the efficacy of methadone results from the combined effects of a number of genetic variants, such as single nucleotide polymorphisms (SNPs). Although there are not enough...
Source: Current Pharmacogenomics and Personalized Medicine - December 11, 2015 Category: Genetics & Stem Cells Source Type: research

A Personalized Approach to Systemic Treatment of Unresectable or Metastatic Pancreatic Adenocarcinoma
Pancreatic cancer is the fourth leading cause of death from cancer. Maximizing therapeutic benefit relies on careful review of inter-individual characteristics. Current and future pharmacogenomics principles may assist in this personal approach and may eventually become widespread. Until then, providers must rely on the available data that might be considered most applicable at the current time. Systemic treatment of unresectable or metastatic pancreatic cancer has been based on gemcitabine and gemcitabine containing combinations for nearly fifteen years. Recently, clinical studies have substantiated two effective combinat...
Source: Current Pharmacogenomics and Personalized Medicine - December 11, 2015 Category: Genetics & Stem Cells Source Type: research

Novel Concepts in Vascular Stent Design: Can Stent be Personalized Through Computational Fluid Dynamics?
In the last few decades, popularity of coronary interventions has risen rapidly. Widespread use of coronary stents and high number of patients with atherosclerosis made the stents the focus of attention by the industry. This has led the stent technology to evolve rapidly. The aim of this review is to outline the evolution of coronary stents and the stent components in the timeline. Pharmacogenomics, personalized medicine and computational fluid dynamics can help us to design individualized stents. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - December 11, 2015 Category: Genetics & Stem Cells Source Type: research

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(Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - December 11, 2015 Category: Genetics & Stem Cells Source Type: research