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Preface
(Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - July 16, 2018 Category: Genetics & Stem Cells Source Type: research

Meet Our Associate Editor
(Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - July 16, 2018 Category: Genetics & Stem Cells Source Type: research

Acknowledgements to Reviewers
(Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - February 21, 2018 Category: Genetics & Stem Cells Source Type: research

Comprehensive in-silico Analysis of High-risk Non-synonymous SNPs in Dectin-1 Gene of Human and their Impact on Protein Structure
Conclusion: We propose that these non-synonymous SNPs in dectin-1 receptor encoding gene could be considered for risk assessment against fungal infections. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - February 21, 2018 Category: Genetics & Stem Cells Source Type: research

Would Polymorphic Variants of Dopamine-2 Receptor Gene (DRD2) and Serotonin Transporter Gene (SERT) be a Common Genetic Risk Factor for Comorbid Drug Abuse and Myocardial Ischemia? A Hypothesis- generating Study
Conclusion: SNPs of the studied genes have made a significant contribution to comorbidity however, further studies are needed to validate the results in a wider population. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - February 21, 2018 Category: Genetics & Stem Cells Source Type: research

Allele Frequencies of Two Main Metformin Transporter Genes: SLC22A1 rs628031 A>G and SLC47A1 rs2289669 G>A among the Javanese Population in Indonesia
Conclusion: The allele frequency of SLC22A1 gene rs628031 in Javanese-Indonesian population was almost the same as those found in Afro-American population as well as in other Asian populations. Similar results were obtained when the A allele frequency of SLC47A1 rs2289669 was compared to those in Chinese population. Further studies are recommended to examine the correlation between these polymorphisms and the variability of pharmacokinetic profiles as well as glycemic response to metformin and its adverse reactions. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - February 21, 2018 Category: Genetics & Stem Cells Source Type: research

Thymidylate Synthase: Predicted Expression Phenotypes Based on Analysis of Haplotypes (5'UTR/3'UTR) in Venezuelan Population
Conclusion: These results are important for pharmacogenetics, because TYMS polymorphisms are potential predictors of 5-FU therapeutic efficacy and toxicity in some cancer treatments. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - February 21, 2018 Category: Genetics & Stem Cells Source Type: research

Multi-Omics and Machine Learning Applications in Precision Medicine
Conclusion: Predictive models based on multi-omics data could be more powerful than those based on a single data type. Future replication studies with much larger sample sizes are essential to confirm the role of the biomarkers identified in these multi-omics studies and will seemingly have key contributions for precision medicine. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - February 21, 2018 Category: Genetics & Stem Cells Source Type: research

Regulation of Sclerostin: An Intriguing Bioinformatics Insight for a Possible Potential Therapeutic Action by Novel Molecules
Conclusion: The mediation of SOST gene under normal and disease conditions has hinted it as a potential therapeutic target, which is further confirmed through bioinformatics approaches. This paves way to attempt a possible regulation of SOST gene action involving peptide / peptidomimetic molecules and charged nanoparticles, especially during orthodontic treatments. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - February 21, 2018 Category: Genetics & Stem Cells Source Type: research

Dynamic Biomarkers of Response to Antiangiogenic Therapies in Colorectal Cancer: A Review
Conclusion: After a decade since the introduction of bevacizumab, no effective predictive biomarkers are available in routine clinical practice. In this review, we summarized the potential candidate dynamic biomarkers that may play a role in this setting. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - February 21, 2018 Category: Genetics & Stem Cells Source Type: research

Cardiovascular Pharmacogenomics
Conclusion: Cardiovascular pharmacogenomics is recommended only for some antiplatelet, anticoagulant and antihypercholesterolemic drugs thanks to standardized pharmacogenetic tests that are helpful in preventing thromboembolic and hemorrhagic events. Despite many studies have demonstrated that the application of pharmacogenetics may be useful also to individualize the therapy with other cardiovascular drugs, the paucity of large clinical trials and of cost-effectiveness studies limits the translation of such knowledge into clinical practice. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - June 23, 2017 Category: Genetics & Stem Cells Source Type: research

Tackling Cardiovascular Risk: New Evidence from Personalized Medicine
Conclusion: Prevention of the Cardiovascular disease still lacks efficient models for personalized medicine, but the definition of the individual Metabolomics may represent a promising approach for filling this gap. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - June 23, 2017 Category: Genetics & Stem Cells Source Type: research

Variability in the Response to Non-pharmacological Treatments in Patients with Cardiovascular Diseases
Conclusion: To date, the efficacy of non-pharmacological strategies, as well as the optimal rehabilitation program remains unclear. The present review highlights the effects of personalizing the non-pharmacological intervention to contrast development and progression of CVD. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - June 23, 2017 Category: Genetics & Stem Cells Source Type: research

Novel Drug Targets for the Treatment of Cardiac Diseases
Conclusion: The global quest for new molecular targets for the treatment of cardiac diseases is leading to an impressive amount of records in the more recent literature. Although several promising molecular pathways have been identified so far, great caution should be used in considering all these targets effective in promoting the production of new drugs. The identification of suitable therapeutic targets is in fact an ongoing challenge that often lacks enough pre-clinical and clinical studies, which hinders the effective utilization of several new drugs due to a lack of efficacy or induction of safety liabilities. (Sourc...
Source: Current Pharmacogenomics and Personalized Medicine - June 23, 2017 Category: Genetics & Stem Cells Source Type: research

Iodinated Contrast Media in Diagnostic Imaging: Cardiovascular Side Effects
Conclusion: The rarity and the mild-moderate type of the cardiovascular side effects do not justify the electrocardiogram test as a preliminary exam for iodine contrast media usage. Emergency medical team should be alert in case of need. Atropine is the first choice in the hypotensive crisis due to contrast agents. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - June 23, 2017 Category: Genetics & Stem Cells Source Type: research