Association of N-acetyltransferase-2 Polymorphism with Antituberculosis Induced Hepatotoxicity: A Meta-analysis
Conclusion: NAT2 polymorphism was significantly associated with ATDIH. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - November 30, 2021 Category: Genetics & Stem Cells Source Type: research

Prevalence of CYP2C19 Polymorphisms in Clopidogrel Treated Turkish Patients: Preliminary Results, 2017
Conclusion: Although our study population does not consist of a high number of patients, since the high frequency of intermediate, rapid and ultra-rapid metabolizer patients were detected in relatively high frequencies, CYP2C19 polymorphisms should be taken into account for efficiency and possible clopidogrel related risks in Turkish cardiac patients. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - November 30, 2021 Category: Genetics & Stem Cells Source Type: research

The Effect of Phytochemical Extracts on Cytokine Gene Expression
Conclusion: The phytochemical compounds in pomegranate extracts and grape seed extracts-cause the anti-inflammatory effect by decreasing the gene expression of IL1β,IL6 and increasing the transcription of IL10. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - November 30, 2021 Category: Genetics & Stem Cells Source Type: research

High-dose Everolimus May Induce Pro-inflammatory/Fibrotic Transcriptomic Changes in Bronchial Epithelial Cells from Cystic Fibrosis Patients
Conclusions: Although performed in vitro, our study suggested that in solid organ transplant recipients with CF without a lung transplant, mTOR-I should be used at a low dosage to reduce its contribution to pulmonary inflammation and fibrosis. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - November 30, 2021 Category: Genetics & Stem Cells Source Type: research

Genomics and Pharmacogenomics of Age-related Hearing Loss
Age-related hearing loss (ARHL) or presbycusis shares common features with conditions related to senescence and neurodegeneration. In this review, we explore the linking of genes involved in such processes with presbycusis, that has been proven to share important relationships with genes involved in dementia (APOE and MTHFR), ototoxicity (the GST group), and pharmacogenetics (NAT2). In this regard, we propose the construction of pharmacogenetics for the presbycusis database that could help better control side effects in this particularly vulnerable population susceptible to neurodegenerative disorders. Moreover, preliminar...
Source: Current Pharmacogenomics and Personalized Medicine - November 30, 2021 Category: Genetics & Stem Cells Source Type: research

Biological and Pharmacogenomics Bases of Gastrointestinal and Some Long-term Selective Serotonin Reuptake Inhibitors-induced Adverse Effects
Conclusion: This review highlights a number of polymorphisms associated with some of the key AEs encountered in SSRI treatments. Standardized study designs in pharmacogenomic evaluations hold great promise for replication of association findings. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - November 30, 2021 Category: Genetics & Stem Cells Source Type: research

Is There Still a Role for Sulfonylureas in Type 2 Diabetes?
(Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - November 30, 2021 Category: Genetics & Stem Cells Source Type: research

Meet the Editorial Board Member
(Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - November 30, 2021 Category: Genetics & Stem Cells Source Type: research

Developing a Standardized Review Process of Pharmacogenomics Resources for Psychotropic Medications
Conclusion: This project resulted in the development of a standard process for reviewing pharmacogenomics- related literature, allowing for more CDS proposals to be accepted. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - September 8, 2021 Category: Genetics & Stem Cells Source Type: research

Comparative Occurrence of TLR3 and TLR7 Polymorphisms Among Healthy Individual of Various Population
Conclusion: The prevalence of TLR3 and TLR7 polymorphisms suggested that genotype-phenotype studies should be conducted among populations to address the innate immune responses against pathogens. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - September 8, 2021 Category: Genetics & Stem Cells Source Type: research

Comparative Genomic and Network Analysis of nNOS by Using Different Bioinformatics Approaches
Conclusion: This study considered evolutionary trend of physical, chemical and biological properties of NOS1 through different phyla. The neuronal Nitric Oxide Synthase (nNOS), being one of the three isoforms of NOS (Nitric Oxide Synthase), is found to be involved in more pathways than just forming Nitric Oxide. This research provides the base for further neurological research. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - September 8, 2021 Category: Genetics & Stem Cells Source Type: research

CYP3A4 *1B Gene Polymorphism in Coronary Artery Disease Patients with Obesity Undergoing Statin Treatment
Conclusion: Our results demonstrate that CYP3A4 *1B homozygous polymorphic genotype distribution tends to be higher in obese patients compared to non-obese patients with cardiovascular disease which may point to *1B allele having a slight effect on serum lipids during statin therapy. Additional studies with higher samples are needed for evaluating the role of CYP3A4 *1B on lipids in patients under statin therapy. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - September 8, 2021 Category: Genetics & Stem Cells Source Type: research

Occurrence of DAT1 (VNTR) Polymorphism in Individuals with HIV Infection
Conclusion: The genetic polymorphism with DAT19/10 genotype was linked with the progression of HIV infection and in the advancement of HIV-related illnesses. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - September 8, 2021 Category: Genetics & Stem Cells Source Type: research

Prediction of Potential Targets of an Emerging Zoonotic Paramyxovirus: An Integrated Bioinformatics Analysis
Conclusion: The above results explicitly demonstrate that the expressed genes attribute to a defensive response against the virus. Henceforth finding agonists for these genes would help in the effective management of Niv infection. (Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - September 8, 2021 Category: Genetics & Stem Cells Source Type: research

Acknowledgements to Reviewers
(Source: Current Pharmacogenomics and Personalized Medicine)
Source: Current Pharmacogenomics and Personalized Medicine - February 1, 2021 Category: Genetics & Stem Cells Source Type: research