Targeting Malignant Melanoma with Physical Plasmas
Publication date: Available online 22 March 2018 Source:Clinical Plasma Medicine Author(s): Gabriella Pasqual Melo, Rajesh Gandhirajan, Ingo Stoffels, Sander Bekeschus Melanoma is the deadliest form of cutaneous neoplasia. With a five-year survival rate of only 5–19%, metastatic melanoma presents severe challenges in clinical therapies. In addition, palliation is often problematic due to large numbers of fast growing metastasis. This calls for new therapeutic avenues targeting highly aggressive melanoma in palliative patients. One recently suggested innovative approach for eradication of topical tumor lesions is th...
Source: Clinical Plasma Medicine - March 23, 2018 Category: Research Source Type: research
Connecting basic cold plasma technology to dermato-oncology
Publication date: Available online 22 March 2018 Source:Clinical Plasma Medicine Author(s): Carsten Weishaupt, Steffen Emmert Cold atmospheric plasma was intensively investigated for medical applications in the last decade and a new field of plasma medicine emerged. Basic components of cold plasma and their biomedical effects were deciphered and mainly relate to redox-biologic effects. With regard to wound treatment, cold plasma already reached standard medical care status. In terms of plasma effects in oncology, only preliminary research data are available. This emerging and highly dynamic field of plasma medicine in ...
Source: Clinical Plasma Medicine - March 23, 2018 Category: Research Source Type: research
Permeabilization of human stratum corneum and full-thickness skin samples by a direct dielectric barrier discharge
Publication date: March 2018 Source:Clinical Plasma Medicine, Volume 9 Author(s): Monika Gelker, Christel C. Müller-Goymann, Wolfgang Viöl A direct ex vivo treatment of human skin with cold atmospheric plasma, specifically a dielectric barrier discharge (DBD) using skin as the ground electrode, is able to permeabilize the stratum corneum (SC) throughout a treated area of 0.5 cm2. Silver sheet oxidation subsequent to a plasma treatment of isolated human SC revealed a regular pattern of local permeabilized regions greater in number than the expected number of skin appendages. The transepithelial electrical resistanc...
Source: Clinical Plasma Medicine - March 16, 2018 Category: Research Source Type: research
Comparing two different plasma devices kINPen and Adtec SteriPlas regarding their molecular and cellular effects on wound healing
Conclusions This comparative study showed that cold atmospheric plasma has several positive effects on wound healing and that kINPen and MicroPlaSter are two devices with substantial, comparable basic research. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - March 16, 2018 Category: Research Source Type: research
Alternative method for healing the diabetic foot by means of a plasma needle
This report presents the results of the case of an 83-year-old woman who was healed of a neuropathic ulcer after being exposed to a helium cold plasma using a plasma needle-type reactor. Along with this antecedent, we propose an alternative method consisting of the application of the helium cold plasma as an adequate option for the treatment and healing of this type of wounds. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - March 16, 2018 Category: Research Source Type: research
Cold Atmospheric Pressure Plasma Jet for the Treatment of Aspergillus Keratitis
Conclusion Both in vitro and in vivo results demonstrated that CAPPJ treatment was effective in inactivating fungal pathogens and therefore it may be considered as a new treatment modality for fungal keratitis. However, further studies are required to investigate its long-term safety. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - December 15, 2017 Category: Research Source Type: research
The effect of polymeric denture modified in low-temperature glow discharge on human oral mucosa: Clinical case
Publication date: Available online 6 November 2017 Source:Clinical Plasma Medicine Author(s): T. Vasilieva, Aung Myat Hein, A. Vargin, E. Kudasova, E. Kochurova, M. Nekludova The modification hot curing poly(methyl methacrylate) (PMMA) denture base “Villacryl H Plus” in RF-discharge plasma is described The plasma chemical modification of PMMA plates in the oxygen RF-discharge (13.56MHz) decreased the water contact angles by 1.5–2.5 times with respect to unmodified samples while their surface free energy increased up to 1.5 times due to the formation of additional oxygen containing polar chemical groups at the...
Source: Clinical Plasma Medicine - November 18, 2017 Category: Research Source Type: research
Platelets are key in cold physical plasma-facilitated blood coagulation in mice
Publication date: December 2017 Source:Clinical Plasma Medicine, Volumes 7–8 Author(s): Sander Bekeschus, Janik Brüggemeier, Christine Hackbarth, Thomas von Woedtke, Lars-Ivo Partecke, Julia van der Linde Surgical interventions inevitably lead to destruction of blood vessels. This is especially dangerous in anticoagulated patients. Electrocauterization is a frequently used technique to seal incised tissue. However, leading to a superficial layer of necrotic tissue, the treated area evolves a high vulnerability to contact, making it prone to detachment. As a result, dangerous postoperative bleeding may occur. Col...
Source: Clinical Plasma Medicine - November 18, 2017 Category: Research Source Type: research
Hyperspectral Imaging for in vivo monitoring of cold atmospheric plasma effects on microcirculation in treatment of head and neck cancer and wound healing
Publication date: Available online 28 September 2017 Source:Clinical Plasma Medicine Author(s): R. Rutkowski, M. Schuster, J. Unger, C. Seebauer, H.R. Metelmann, Th.v. Woedkte, K.D. Weltmann, G. Daeschlein Beside a proven antimicrobial and inflammatory-modulating spectrum of plasma therapy, recent studies point to impressive molecular and cellular effects against tumor cells. However, underlying mechanisms of anticancer effects and improved wound healing, in particular plasma associated influence on microcirculation, have not been sufficiently clarified yet. To date, there is no convincing method for monitoring t...
Source: Clinical Plasma Medicine - September 29, 2017 Category: Research Source Type: research
Clinical Experience with Cold Plasma in the Treatment of Locally Advanced Head and Neck Cancer
Conclusion The trial demonstrates the clinical relevance of CAP in cancer treatment. There are three approaches for discussion of tumor remission: (i) the role of myeloid cells, (ii) the ROS/RNS model of cellular impact and (iii) the immunogenic cell death model of cancer treatment, and there is a reflection on non-sustainable tumor response due to adapted tumor microenvironment. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - September 24, 2017 Category: Research Source Type: research
Enhancement of cancerous cells treatment by applying cold atmospheric plasma and photo dynamic therapy simultaneously
Publication date: December 2017 Source:Clinical Plasma Medicine, Volumes 7–8 Author(s): Leila Karami-Gadallo, Mahmood Ghoranneviss, Leila Ataie-Fashtami, Majid Pouladian, Dariush Sardari Cold atmospheric plasma (CAP) has recently emerged as a novel approach to treat cancer as well as Photo Dynamic Therapy (PDT). The Produced ionized gas (i.e. helium, here) involves highly reactive species which are cell killing responsible in CAP treatments. The photosensitizer 5-Aminolevulinic acid (ALA) was utilized for PDT process. In this paper, the effectiveness of these two techniques separately and also together was examine...
Source: Clinical Plasma Medicine - September 15, 2017 Category: Research Source Type: research
Enhancement of Cancerous Cells Treatment by Applying Cold Atmosphere Plasma and Photo Dynamic Therapy Simultaneously
Publication date: Available online 31 August 2017 Source:Clinical Plasma Medicine Author(s): Leila Karami-Gadallo, Mahmood Ghoranneviss, Leila Ataie-Fashtami, Majid Pouladian, Dariush Sardari Cold atmospheric plasma (CAP) has recently emerged as a novel approach to treat cancer as well as Photo Dynamic Therapy (PDT). The Produced ionized gas (i.e. helium, here) involves highly reactive species which are cell killing responsible in CAP treatments. The photosensitizer 5-Aminolevulinic acid (ALA) was utilized for PDT process. In this paper, the effectiveness of these two techniques separately and also together was exam...
Source: Clinical Plasma Medicine - September 1, 2017 Category: Research Source Type: research
Cold atmospheric plasma treatment affects early bacterial adhesion and decontamination of soft reline palatal obturators
Publication date: Available online 18 August 2017 Source:Clinical Plasma Medicine Author(s): Anna Liguori, Andrea Cochis, Augusto Stancampiano, Romolo Laurita, Barbara Azzimonti, Rita Sorrentino, Elena Varoni, Marta Petri, Vittorio Colombo, Matteo Gherardi, Lia Rimondini The aim of this work was to evaluate cold atmospheric plasma bactericide activity towards biofilm formation on soft reline oral palatal obturators. Plasma was generated using two dielectric barrier discharge and tested against the oral biofilm formers Streptococcus mutans and Aggregatibacter actinomycetemcomitans. Relines were either plasma tr...
Source: Clinical Plasma Medicine - August 19, 2017 Category: Research Source Type: research
Redox regulation of leukocyte-derived microparticle release and protein content in response to cold physical plasma-derived oxidants
Publication date: December 2017 Source:Clinical Plasma Medicine, Volumes 7–8 Author(s): Sander Bekeschus, Juliane Moritz, Anke Schmidt, Kristian Wende Recent results in the field of plasma medicine are increasingly motivating the use of cold physical plasma in clinical settings. Especially two major health issues, non-healing wounds and cancers, are in focus of current research. The outcome of both diseases is highly dependent on inflammation, a process that is priory driven by leukocytes. It is known that these cells are able to tune the behavior and inflammatory status of other cells in a paracrine fashion via re...
Source: Clinical Plasma Medicine - August 15, 2017 Category: Research Source Type: research
Human health risk evaluation of a microwave-driven atmospheric plasma jet as medical device
Publication date: December 2017 Source:Clinical Plasma Medicine, Volumes 7–8 Author(s): A. Lehmann, F. Pietag, Th. Arnold The aim of this study was the characterisation of a microwave-driven atmospheric plasma jet (APJ) dedicated for medical applications. The scientific focus includes harmless sterilization of surfaces and therapeutic treatments in dentistry. Therefore, the plasma was investigated with respect to potential health risks for human beings, which could occur especially by the gas temperature, heat flow, patient leakage current, UV emission and ozone emission from the plasma jet, according to DIN SPEC 91...
Source: Clinical Plasma Medicine - August 15, 2017 Category: Research Source Type: research
