Head and neck Cancer treatment and physical plasma
This study is a retrospective review of representing clinical follow-up of 12 patients afflicted with advanced squamous cell carcinoma of the head and neck. Herein, we have used novel physical cold atmospheric pressure plasma (CAP) to decontaminate infected cancer ulcerations and evaluated anti-cancer effects. With use of CAP in this cohort, the data suggests: 1) decreased request for pain medication and 2) reduction of typical fetid odor related to 3) reduction of microbial load. In some cases there is 4) superficial partial remission of tumor and even 5) wound healing of infected ulcerations has been observed following C...
Source: Clinical Plasma Medicine - March 5, 2015 Category: Research Source Type: research
Plasma deposited silicon oxide Films for controlled permeation of copper as antimicrobial agent
Publication date: Available online 11 February 2015 Source:Clinical Plasma Medicine Author(s): Antje Lehmann , Stefan Rupf , Andreas Schubert , Isabella-Maria Zylla , Hans Jürgen Seifert , Axel Schindler , Thomas Arnold The aim of this study is to test silicon oxide (SiOx) coatings on copper surfaces as permeation barrier for copper ions affecting the release into the surrounding medium. SiOx films have been deposited on copper coated micro-structured titanium samples by means of a plasma jet. Siloxane layers have been formed from hexamethyldisiloxane (HMDSO) and oxygen using different mixing ratios. FT-IR spec...
Source: Clinical Plasma Medicine - February 13, 2015 Category: Research Source Type: research
IBC - Aims and Scopes
Publication date: December 2014 Source:Clinical Plasma Medicine, Volume 2, Issue 2 (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - December 12, 2014 Category: Research Source Type: research
Oxy-nitroso shielding burst model of cold atmospheric plasma therapeutics
Publication date: Available online 13 November 2014 Source:Clinical Plasma Medicine Author(s): David B Graves It is postulated that cold atmospheric plasma (CAP) can trigger a therapeutic shielding response in tissue by creating a time- and space-localized, burst-like form of oxy-nitrosative stress on near-surface exposed cells through the flux of plasma-generated reactive oxygen and nitrogen species (RONS). RONS-exposed surface layers of cells communicate to the deeper levels of tissue via a form of the ‘bystander effect,’ similar to responses to other forms of cell stress. In this proposed model of CAP therapeut...
Source: Clinical Plasma Medicine - November 14, 2014 Category: Research Source Type: research
Ex vivo human skin experiments for the evaluation of safety of new cold atmospheric plasma devices
Publication date: June 2013 Source:Clinical Plasma Medicine, Volume 1, Issue 1 Author(s): G. Isbary , J. Köritzer , A. Mitra , Y.-F. Li , T. Shimizu , J. Schroeder , J. Schlegel , G.E. Morfill , W. Stolz , J.L. Zimmermann Cold atmospheric plasma is an innovative tool in medicine and hygiene. However, there are no regulations or recommendations for experiments to prove the safety of upcoming devices yet. Healthy ex vivo human skin samples were treated with new upcoming plasma devices (FlatPlaSter 2.0 and MiniFlatPlaSter) for safety purposes. The results indicate—besides the safety measurements/calculations ...
Source: Clinical Plasma Medicine - November 1, 2014 Category: Research Source Type: research
Scar formation of laser skin lesions after cold atmospheric pressure plasma (CAP) treatment: A clinical long term observation
Publication date: June 2013 Source:Clinical Plasma Medicine, Volume 1, Issue 1 Author(s): Hans-Robert Metelmann , Thi Thom Vu , Hoang Tung Do , Thi Nguyen Binh Le , Thi Ha Anh Hoang , Thi Thu Trang Phi , Tran My Linh Luong , Van Tien Doan , Thi Trang Huyen Nguyen , Thi Hong Minh Nguyen , Thuy Linh Nguyen , Dinh Quyen Le , Thi Kim Xuan Le , Thomas von Woedtke , René Bussiahn , Klaus-Dieter Weltmann , Roya Khalili , Fred Podmelle CAP treatment is likely to be of benefit in wound healing. In a clinical study, 20 laser lesions in five individuals have been treated with argon plasma 10, 30 or three times ...
Source: Clinical Plasma Medicine - November 1, 2014 Category: Research Source Type: research
Atmospheric pressure plasma in dermatology: Ulcus treatment and much more
Publication date: June 2013 Source:Clinical Plasma Medicine, Volume 1, Issue 1 Author(s): Steffen Emmert , Franziska Brehmer , Holger Hänßle , Andreas Helmke , Nina Mertens , Raees Ahmed , Dirk Simon , Dirk Wandke , Wolfgang Maus-Friedrichs , Georg Däschlein , Michael P. Schön , Wolfgang Viöl Plasma in the sense of ionized gas can be referred to as the fourth state of matter following solids, liquids, and gases in view of their energy content. Application of high voltages across small gas filled spaces results in ionization of the air. Generally, two types of cold plasma can be discerned: direct plasma...
Source: Clinical Plasma Medicine - November 1, 2014 Category: Research Source Type: research
Non-thermal plasma—More than five years of clinical experience
Publication date: June 2013 Source:Clinical Plasma Medicine, Volume 1, Issue 1 Author(s): G. Isbary , J.L. Zimmermann , T. Shimizu , Y.-F. Li , G.E. Morfill , H.M. Thomas , B. Steffes , J. Heinlin , S. Karrer , W. Stolz Non-thermal plasma technology emerged the medical field in an age of increasing bacterial and fungal resistance and global concerns about hygiene in different health care settings. Thus, the expectations regarding this new promising tool are very high. After teething problems different non-thermal plasma technologies were developed and used in different clinical trials in patients possessing c...
Source: Clinical Plasma Medicine - November 1, 2014 Category: Research Source Type: research
Suitability of tissue tolerable plasmas (TTP) for the management of chronic wounds
Publication date: June 2013 Source:Clinical Plasma Medicine, Volume 1, Issue 1 Author(s): A. Kramer , J. Lademann , C. Bender , A. Sckell , B. Hartmann , S. Münch , P. Hinz , A. Ekkernkamp , R. Matthes , I. Koban , I. Partecke , C.D. Heidecke , K. Masur , S. Reuter , K.D. Weltmann , S. Koch , O. Assadian This review considers qualifying standards of wound management, explains the hypothesis for the applicability of tissue tolerable plasma (TTP) and lists the TTP effects relevant for wound healing. TTP fulfils these requirements in-vitro and in-vivo together with its demonstrated good tissue tolerabili...
Source: Clinical Plasma Medicine - November 1, 2014 Category: Research Source Type: research
Risk assessment of the application of tissue-tolerable plasma on human skin
Publication date: June 2013 Source:Clinical Plasma Medicine, Volume 1, Issue 1 Author(s): J. Lademann , C. Ulrich , A. Patzelt , H. Richter , F. Kluschke , M. Klebes , O. Lademann , A. Kramer , K.D. Weltmann , B. Lange-Asschenfeldt The results of the risk assessment of the tissue-tolerable plasma (TTP) jet kINPen med® and first results of pilot clinical studies are presented. Producing an atmospheric pressure plasma, this plasma jet entails no risk for humans in terms of temperature increase, UV radiation or free radical formation by the plasma. The antiseptic efficacy in vitro on porcine skin and in vivo on...
Source: Clinical Plasma Medicine - November 1, 2014 Category: Research Source Type: research
Clinical plasma medicine—position and perspectives in 2012 Paper of consent, result of the workshop “Clinical Concepts in Plasma Medicine”, Greifswald April 28th, 2012
Publication date: June 2013 Source:Clinical Plasma Medicine, Volume 1, Issue 1 Author(s): Steffen Emmert , Georg Isbary , Franziska Kluschke , Jürgen Lademann , Fred Podmelle , Hans-Robert Metelmann , Georg Daeschlein , Kai Masur , Thomas von Woedtke , Klaus-Dieter Weltmann (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - November 1, 2014 Category: Research Source Type: research
In vivo skin treatment using two portable plasma devices: Comparison of a direct and an indirect cold atmospheric plasma treatment
Publication date: December 2013 Source:Clinical Plasma Medicine, Volume 1, Issue 2 Author(s): Y.-F. Li , D. Taylor , J.L. Zimmermann , W. Bunk , R. Monetti , G. Isbary , V. Boxhammer , H.-U. Schmidt , T. Shimizu , H.M. Thomas , G.E. Morfill Two cold atmospheric plasma devices were used (either in an indirect or a direct way) for the treatment of physiologically contaminated forearms in 12 healthy volunteers. After 30s of plasma treatment, the log reduction of the bacterial load in the plasma treated area was evaluated. It was found that both the indirect and direct plasma application resulted in a highly sig...
Source: Clinical Plasma Medicine - November 1, 2014 Category: Research Source Type: research
Decontamination of human skin by low-temperature plasma produced by cometary discharge
Publication date: December 2013 Source:Clinical Plasma Medicine, Volume 1, Issue 2 Author(s): Jaroslav Julák , Vladimír Scholtz Low-temperature plasma produced by DC cometary discharge suppresses bacteria on live human skin of the inner arm side and fingertips. In model experiments, this discharge in open air completely suppressed Escherichia coli within 8min, whereas Staphylococcus epidermidis was markedly lowered, but not completely eliminated even after 10min. After inserting an insulated grid and exposure in an enclosed chamber, E. coli was completely suppressed within 2–4min and S. epidermidis within 10min. ...
Source: Clinical Plasma Medicine - November 1, 2014 Category: Research Source Type: research
Cold atmospheric argon plasma treatment may accelerate wound healing in chronic wounds: Results of an open retrospective randomized controlled study in vivo
This study suggests that wound healing may be accelerated, particularly for chronic venous ulcers. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - November 1, 2014 Category: Research Source Type: research
Towards a plasma treatment of corneal infections
Publication date: December 2013 Source:Clinical Plasma Medicine, Volume 1, Issue 2 Author(s): E. Martines , P. Brun , P. Brun , R. Cavazzana , V. Deligianni , A. Leonardi , E. Tarricone , M. Zuin Infectious keratitis of the eye is induced by proliferation and penetration of microorganisms in the cornea. The possibility of developing a novel treatment for this condition based on the action of a low temperature, atmospheric pressure plasma is presented. In-vitro results show that bacteria and fungi responsible of keratitis are inactivated by the exposure to the afterglow of a RF plasma produced in a helium flow m...
Source: Clinical Plasma Medicine - November 1, 2014 Category: Research Source Type: research
