Regulation Of Antigen-Presenting Machinery In Melanoma After Plasma Treatment
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Ramona Clemen, Thomas von Woedtke, Sander Bekeschus Cold physical plasmas have been shown to eliminate multiple types of cancers in vitro and in vivo [1] Although being multi-component systems, evidence suggest plasmas to be active primarily via release of a plethora of reactive oxygen and nitrogen species (ROS/RNS). These species not only damage cells via oxidation of proteins and lipids but also trigger signaling cascades via redox relays. This redox signaling is vital for a number of processes, e.g. the formation and lo...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Plasma Elicits Immunogenic Death In Melanoma Cells
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Abraham Lin, Yury Gorbanev, Paul Cos, Evelien Smits, Annemie Bogaerts Development of non-thermal plasma for cancer immunotherapeutic applications has received growing attention, namely for induction of immunogenic cancer cell death (ICD). Cancer cells undergoing ICD emit signals known as damage-associated molecular patterns (DAMPs), that can attract and stimulate local immune cells [1]. Of these, membrane-bound calreticulin is a key DAMP signal that facilitates engulfment of cancer cells by dendritic cells, a critical pr...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Treatment Of Hypoxic Tumours With Plasma Jets
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Endre Szili, Jun-Seok Oh, Hideo Fukuhara, Keiji Inoue, Akimitsu Hatta, Rob Short A challenge in cancer therapy is the destruction of tumours, where there is the potential issue of cancer cells residing within hypoxic tissue. The concept of hypoxic regions within tumours dates back to 1909 and it has long been suspected that under low oxygen tension, cells are “afforded” radiation protection. It has been shown many decades ago, that raising the concentration of oxygen in tissues can significantly improve the outcomes...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Plasmas, membranes, and transport across the membranes
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Lluis M. Mir Physical agents, like cold plasma, may affect the cells at various levels, amongst which the cell membrane. Cell or “plasma” membrane is a vital “organ” for the cell. Indeed if cell membrane integrity is affected, transports from cell outside to cell inside and from cell inside to cell outside can no longer be regulated [1]. It is essential for the cell physiology and survival to keep fully regulated the transport across the cell membrane of ions (Na+, Ca++, K+, Cl-), of small molecules (sugars, ATP, ami...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Comparison of AC plasma jets between dielectric barrier discharge and surface barrier discharge
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Insun Park, Sang-You Kim, Inje Kang, Min-keun Bae, Yoonje Lee, Yeongtak Song, Tae Ho Lim, Kyu-Sun Chung For plasma to be applied to practical medical tools, the length of plasma column and plasma density should be well controlled in non-thermal atmospheric pressure plasma jets, although active radicals are the real ones to react with the human surfaces. AC plasma jets from two different discharge modes (dielectric barrier discharge and surface barrier discharge) have been compared in terms of plasma and neural paramet...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Cold plasma treatment of in vitro gliomas and patient-derived tumors – Role of human myeloid cells
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Sascha Marx, Frederik Kinnen, Juliane Moritz, Eric Freund, Mathias Stope, Sandra Bien-Möller, Bernhard H. Rauch, Christopher Ritter, Henry W.S. Schroeder, Sander Bekeschus Tumor-associated macrophages (TAM) are the pre-dominant myeloid cells within malignant glioma and are a poor prognostic factor in patients. TAM in malignant glioma show a tumor-supporting, so-called M2 phenotype. The aim of this study was to characterize phenotype and relevant markers of monocytes/macrophages in the tumor microenvironment followi...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Flexible Electronics Technologies for the Fabrication of Surface Dielectric Barrier Discharge Devices
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Do-Geun Kim, Sunghoon Jung, Seunghun Lee Flexible electronics have been extensively studied for the development of flexible displays and semiconductor devices. Heterojunction and patterning techniques between metal and polymer have been studied to realize complicated electrode wiring.[1] Flexible electronics technologies can also be used to fabricate devices for surface dielectric barrier discharge (SDBD). Recently, SDBD were developed as a flexible device based on polymer dielectric substrates.[2] The flexible devices usi...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Surface Dielectric Barrier Discharge Devices for Low Voltage and Low Power Radical Sheet
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Seunghun Lee, Sunghoon Jung, Do-Geun Kim To improve the electrical stability and portability of surface dielectric barrier discharge (SDBD) devices, it is necessary to secure low voltage and low power operations of SDBD. We fabricated polymer SDBD devices using commercial polymer substrates such as polyimide, polyethylene terephthalate. Functional thin film coatings were adapted to protect the degradation of polymer substrate due to reactive oxygen radicals. And the optimization of the electrode structure was conducted to ...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Air Dielectric Barrier Discharge Plasma Source For In Vitro Cancer Studies
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Ioana Cristina Gerber, Cosmin Teodor Mihai, Lucian Gorgan, Mitica Ciorpac, Alexandru Nita, Valentin Pohoata, Ilarion Mihaila, Ionut Topala For most cancer studies involving plasma treatments, the cell cultures require a significant amount of manipulation before and after treatment. This increases the risk of contamination and of damaging the cells. The well plates are used for growing cell cultures, and a discharge adapted to their geometry would minimize cell culture manipulation during exposures and biological assay...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Atmospheric Pressure Multijet Plasma Sources For Cancer Treatments
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Thomas Maho, Xavier Damany, Sébastien Dozias, Jean-Michel Pouvesle, Eric Robert Single plasma jets have allowed significant advances in in vivo or directly on human experiments (e.g. [1],[2]). The results are particularly promising, but ultimately likely to be limited in the future due to the fact that the treatment times are rather long due to the very small treated surface area resulting from the produced plasma. There is a real challenge to develop sources that allow treatment over larger areas while remaining practi...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Gwu-Usmi Plasma Medicine Research Program
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Jerome Canady, Barry Trink, Jonathan Sherman, Michael Keidar This talk will introduce the recently established joint program on plasma cancer therapy between USMI and GWU. The use of cold atmospheric plasma-based instruments resulting from prior collaborations between USMI and GWU have already shown promise in the treatment of cancer. In January 2016, a surgical team used the Canady HeliosTM Cold Plasma Scalpel to selectively kill cancerous tissue during a two-stage liver resection in a patient with advanced inoperable li...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Consequences Of Environmental Factors In Plasma Treatment Of Liquids, Tissues And Materials
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Juliusz Kruszelnicki, Amanda M. Lietz, Guy Parsey, Soheila Mohades, Mark J. Kushner The approved use of atmospheric pressure plasma sources in treatment of biological materials has as one consideration the ability to reproduce the procedure. In this context, the environment in which the plasma source is operated is a factor. Environment is used here in the most general way to refer to all components surrounding or interacting with the plasma source that may affect the dose delivered to the biological material. These comp...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Advanced Control Of Plasma Medical Devices
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): David Graves, Dogan Gidon, Brandon Curtis, Daniel Elg, Ali Mesbah Atmospheric pressure plasma jets (APPJs) have widespread use in plasma medicine. This presentation aims to demonstrate the importance of using advanced control strategies for safe, reproducible, and therapeutically effective application of APPJs for dose delivery to a target substrate. Key challenges in advanced control of APPJs arise from: (i) the multivariable, nonlinear nature of system dynamics, (ii) the need to constrain the system operation within an...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
5th International Workshop on Plasma for Cancer Treatment (IWPCT 2018) Greifswald, Germany, 20-21 March 2018
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Puublication Information
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
